Worse prognosis for IDH wild-type diffuse gliomas with larger residual biological tumor burden

Tatekawa, Hiroyuki; Uetani, Hiroyuki; Hagiwara, Akifumi; Bahri, Shadfar; Raymond, Catalina; Lai, Albert; Cloughesy, Timothy F.; Nghiemphu, Phioanh L.; Liau, Linda M.; Pope, Whitney; Salamon, Noriko; Ellingson, Benjamin M.

doi:10.1007/s12149-021-01637-0

Cited by 5 publications

(5 citation statements)

References 29 publications

(40 reference statements)

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“…Likelihood ratios (LR) were used here as an alternative statistic for summarising diagnostic accuracy, as this approach does not depend on disease prevalence and is a more clinically useful measure than sensitivity and specificity 28 . LR was divided into PLR and NLR, where PLR is the ratio of the probability of a specific test result in a diseased population to the probability in a non‐diseased population, 29 and NLR is the opposite 30 . Typically a PLR above 10/NLR value below 0.1 would be considered strong evidence with which to rule in/rule out disease 31 .…”

Section: Discussionmentioning

confidence: 99%

A prospective comparison of a modified miniaturised hand‐held epifluorescence microscope and touch imprint cytology for evaluation of axillary sentinel lymph nodes intraoperatively in breast cancer patients

Chen,

Yu,

Shen

et al. 2023

Cytopathology

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BackgroundThe management of axillary lymph nodes in early‐stage breast cancer patients has changed considerably, with the primary focus shifting from the examination of sentinel lymph nodes (SLNs) to toward the detection of all macro‐metastases. However, current methods, such as touch imprint cytology (TIC) and frozen sections, are inadequate for clinical needs. To address this issue, we proposed a novel miniaturised epifluorescence widefield microscope (MEW‐M) to assess SLN status intraoperatively for improved diagnostic efficiency.MethodsA prospective, side‐by‐side comparison of intraoperative SLN evaluation between MEW‐M and TIC was performed.ResultsA total of 73 patients with 319 SLNs consecutive enrolled in this study. MEW‐M showed significantly superior image quality compared to TIC (median score 3.1 vs 2.1, p < 0.0001) and had a shorter time to issue results (10.3 vs 19.4 min, p < 0.0001). Likelihood ratio analysis illustrated that the positive likelihood ratio value of MEW‐M compared with TIC was infinitely great vs 52.37 (95% CI, 21.96‐124.90) in model 1 (classifying results into negative/positive), infinitely great vs 52.37 (95% CI, 21.96‐124.90) in model 2 (classifying results into macro‐metastasis/others, and TIC results followed the same classification as model 1), respectively. Similarly, the negative likelihood ratio values of MEW‐M compared with TIC were 0.055 (95% CI, 0.018‐0.160) and 0.074 (95% CI, 0.029‐0.190) in model 1; and 0.019 (95% CI, 0.003‐0.130) vs 0.020 (95% CI, 0.003‐0.140) in model 2, respectively.ConclusionsMEW‐M is a promising technique that can be utilised to provide a rapid and accurate intraoperative assessment of SLN in a clinical setting to help improve decision‐making in axillary surgery.

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Section: Discussionmentioning

confidence: 99%

A prospective comparison of a modified miniaturised hand‐held epifluorescence microscope and touch imprint cytology for evaluation of axillary sentinel lymph nodes intraoperatively in breast cancer patients

Chen,

Yu,

Shen

et al. 2023

Cytopathology

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“…Moreover, Tatekawa et al. showed that Flair hyperintense volume for IDH wild-type gliomas showed no significant association with OS ( 28 ). If the edema area is defined as the GTV of NE-LGGs, which can ensure the radiation dose coverage of tumor, the radiation damage risk to the surrounding healthy tissues will be increased due to the large.…”

Section: Discussionmentioning

confidence: 99%

“…The research of Jakola et al (27) showed that the blood-brain barrier was destroyed after the malignant transformation of NE-LGGs, and the enhanced area was much smaller than the edema area. Moreover, Tatekawa et al showed that Flair hyperintense volume for IDH wild-type gliomas showed no significant association with OS (28). If the edema area is defined as the GTV of NE-LGGs, which can ensure the radiation dose coverage of tumor, the radiation damage risk to the surrounding healthy tissues will be increased due to the large.…”

Section: Mostmentioning

confidence: 99%

Three-Dimensional Arterial Spin Labeling-Guided Sub-Volume Segmentation of Radiotherapy in Adult Non-Enhancing Low-Grade Gliomas

et al. 2022

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ObjectiveThe present study aimed to evaluate the feasibility of sub-volume segmentation for radiotherapy planning of adult non-enhancing low-grade gliomas (NE-LGGs) guided by three-dimensional arterial spin labeling (3D-ASL). The differences in high- and low-perfusion areas of NE-LGGs were analyzed using multi-sequence magnetic resonance imaging (MRI) radiomics.MethodsFifteen adult patients with NE-LGGs were included in the study. MR images, including T1-weighted imaging (T1WI), T2 Propeller, T2 fluid-attenuated inversion recovery (T2 Flair), 3D-ASL, and contrast-enhanced T1WI (CE-T1WI), were obtained. The gross tumor volume (GTV) was delineated according to the hyperintensity on T2 Flair. The GTV was divided into high- and low-perfusion areas, namely GTV-ASL and GTV-SUB, respectively, based on the differences in cerebral blood flow (CBF) value. The volumes and CBF values of high- and low-perfusion areas were measured and compared. The least absolute shrinkage and selection operator (LASSO) regression was used to select the optimal features of all MR maps. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic accuracy of the absolute CBFmean (aCBFmean), relative CBFmean (rCBFmean, normalized by the CBF value of the normal gray matter), and screened features in differentiating high- and low-perfusion areas.ResultsAmong the enrolled patients, three (20%) patients with NE-LGGs showed focal intra- and post-radiotherapy contrast enhancement within a prior high-perfusion area of 3D-ASL. The volume ratio of the GTV-ASL to the GTV was (37.08% ± 17.88)% (46.26 ± 44.51 vs. 167.46 ± 209.64 cm3, P = 0.000). The CBFmean in the high-perfusion area was approximately two times of that in the edema area or normal gray matter (66.98 ± 18.03 vs. 35.19 ± 7.75 or 33.92 ± 8.48 ml/100g/min, P = 0.000). Thirteen features were screened, seven of which were extracted from 3D-ASL. The area undercurve (AUC) values of aCBFmean, rCBFmean, and firstorder_10Percentile from 3D-ASL were more than 0.9, of which firstorder_10Percentile was the highest. Their cut-off values were 44.16 ml/100 g/min, 1.49 and 31, respectively.ConclusionThe difference in blood perfusion in the GTV can be quantified and analyzed based on 3D-ASL images for NE-LGGs, which could guide the sub-volume segmentation of the GTV. 3D-ASL should become a routine method for NE-LGGs during simulation and radiotherapy.

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“…No relationship was observed between the LAT1 levels and tumor uptake capacity, suggesting that the possible lack of 18 F-FET uptake is not due to the poor expression of LAT1. The association between the biological tumor volume, as determined by different techniques including contrast-enhanced volume on T1-weighted images, FLAIR hyperintense volume, and 3,4-dihydroxy-6- 18 F-fluoro-L-phenylalanine ( 18 FDOPA) hypermetabolic volume and the OS of IDH wild-type HGG patients has been studied by Tatekawa and co-workers [ 31 ]. Regardless of the tumor grade, 18 FDOPA hypermetabolic volume best predicted the OS of patients with IDH wild-type gliomas [ 31 ].…”

Section: Advances In Diagnosismentioning

confidence: 99%

Recapitulating the Key Advances in the Diagnosis and Prognosis of High-Grade Gliomas: Second Half of 2021 Update

Fròsina

2023

IJMS

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High-grade gliomas (World Health Organization grades III and IV) are the most frequent and fatal brain tumors, with median overall survivals of 24–72 and 14–16 months, respectively. We reviewed the progress in the diagnosis and prognosis of high-grade gliomas published in the second half of 2021. A literature search was performed in PubMed using the general terms “radio* and gliom*” and a time limit from 1 July 2021 to 31 December 2021. Important advances were provided in both imaging and non-imaging diagnoses of these hard-to-treat cancers. Our prognostic capacity also increased during the second half of 2021. This review article demonstrates slow, but steady improvements, both scientifically and technically, which express an increased chance that patients with high-grade gliomas may be correctly diagnosed without invasive procedures. The prognosis of those patients strictly depends on the final results of that complex diagnostic process, with widely varying survival rates.

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Worse prognosis for IDH wild-type diffuse gliomas with larger residual biological tumor burden

Cited by 5 publications

References 29 publications

A prospective comparison of a modified miniaturised hand‐held epifluorescence microscope and touch imprint cytology for evaluation of axillary sentinel lymph nodes intraoperatively in breast cancer patients

A prospective comparison of a modified miniaturised hand‐held epifluorescence microscope and touch imprint cytology for evaluation of axillary sentinel lymph nodes intraoperatively in breast cancer patients

Three-Dimensional Arterial Spin Labeling-Guided Sub-Volume Segmentation of Radiotherapy in Adult Non-Enhancing Low-Grade Gliomas

Recapitulating the Key Advances in the Diagnosis and Prognosis of High-Grade Gliomas: Second Half of 2021 Update

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