Worse outcomes of early targeted ibuprofen treatment compared to expectant management of patent ductus arteriosus in extremely premature infants

Termerova, Jana; Kubêna, Aleŝ; Paslerová, Ráchel; Liška, Karel

doi:10.4103/jcn.jcn_73_21

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to this hypothesis, PDA closure is expected to normalize pulmonary perfusion, as supported by data from a baboon model showing improved alveolarization after ibuprofen treatment. 23 The suggestion of a higher risk of bronchopulmonary dysplasia in the ibuprofen group is consistent with observational data showing associations between ibuprofen use and the development of bronchopulmonary dysplasia 24,25 and is supported by in vitro and in vivo studies suggesting that angiogenesis may be inhibited by ibuprofen. 26,27 A recent prospective study showed decreased vascular growth factors in preterm infants with PDA after exposure to ibuprofen.…”

Section: Discussionsupporting

confidence: 74%

Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus

Hundscheid,

Onland,

Kooi

et al. 2023

Obstetric Anesthesia Digest

View full text Add to dashboard Cite

(N Engl J Med. 2023;388:980–990) Patent ductus arteriosus (PDA), where the vessel connecting the pulmonary artery and aorta does not properly close, is a common adverse outcome for preterm birth. Cyclooxygenase inhibitors are used to help treat PDA but the evidence and clinical outcome benefits are lacking. This study aimed to answer the question whether expectant management or ibuprofen treatment in extremely preterm infants with PDA are a superior treatment.

show abstract

Section: Discussionsupporting

confidence: 74%

Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus

Hundscheid,

Onland,

Kooi

et al. 2023

Obstetric Anesthesia Digest

View full text Add to dashboard Cite

show abstract

“…Clyman et al also found the association between BPD and hsPDA depended on the length of intubation 27 . PDA treatment can have serious side effects and negatively affect other functions in immature neonatal organs 28,29 . However, further studies are required to address this issue.…”

Section: Discussionmentioning

confidence: 99%

Association between patent ductus arteriosus flow and home oxygen therapy in extremely preterm infants

Termerova,

Kubena,

Liska

et al. 2024

Pediatr Res

Self Cite

View full text Add to dashboard Cite

Background Central blood flow measurements include the estimation of right and left ventricular output (RVO, LVO), superior vena cava (SVC) flow, and calculated patent ductus arteriosus (PDA) flow. We aimed to provide an overview of the maturation patterns of these values and the relationship between PDA flow and the need for home oxygen therapy. Methods This prospective single-center study was conducted in infants born at <26 weeks of gestation. We performed echocardiographic measurements five times during their life (from the 4th post-natal day to the 36th postmenstrual week). Results Sixty patients with a mean birth weight of 680 (590, 760) g were included. Postnatal development of LVO and PDA flow peaked at the end of the second postnatal week (427 and 66 mL/kg/min, respectively). The RVO increased between days 4 and 7–8. The SVCF was most stable. The development curves of PDA flow differed between the groups with (n = 28; 47%) and without home oxygen therapy. Conclusion We present the central blood flow values and their postnatal development in infants <26 weeks of gestation. This study demonstrates the association between PDA flow and the future need for home oxygen therapy. Impact This study enriches our knowledge of the long-term development of central blood flow parameters and derived patent ductus arteriosus (PDA) flow in extremely preterm infants (<26 weeks). While pulmonary resistance decreased, PDA flow continued to increase from day 4 to the end of the second week of life. Similarly, left ventricular output increased as a marker of preload. The superior vena cava flow remained stable. The observed association between PDA flow and an unfavorable respiratory outcome is important for future studies focusing on the prevention of chronic lung disease.

show abstract