WormKill to WormBoss—Can we sell sustainable sheep worm control?

Woodgate, Robert; Love, S. C. J.

doi:10.1016/j.vetpar.2011.11.045

Cited by 36 publications

(19 citation statements)

References 27 publications

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“…Nevertheless, convincing farmers to convert to TST strategies may not be straightforward, as has been suggested for sheep, especially because the benefits from reducing the rate of anthelmintic resistance development may not be immediately obvious. The relative advantage, complexity and compatibility of TST strategies are all important factors taken into consideration by the farming industry (for which varied priorities exist) (Woodgate and Love, 2012). Difficulties in quantifying such factors make it challenging for farmers to visualise the problem and subsequent benefits of TST, steps towards quantifying these are essential as change is more likely to be adopted when the problem is obvious (Rogers, 1995).…”

Section: Discussionmentioning

confidence: 99%

Modelling the consequences of targeted selective treatment strategies on performance and emergence of anthelmintic resistance amongst grazing calves

Berk

Laurenson

Forbes

et al. 2016

International Journal for Parasitology: Drugs and Drug Resistan

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The development of anthelmintic resistance by helminths can be slowed by maintaining refugia on pasture or in untreated hosts. Targeted selective treatments (TST) may achieve this through the treatment only of individuals that would benefit most from anthelmintic, according to certain criteria. However TST consequences on cattle are uncertain, mainly due to difficulties of comparison between alternative strategies. We developed a mathematical model to compare: 1) the most ‘beneficial’ indicator for treatment selection and 2) the method of selection of calves exposed to Ostertagia ostertagi, i.e. treating a fixed percentage of the population with the lowest (or highest) indicator values versus treating individuals who exceed (or are below) a given indicator threshold. The indicators evaluated were average daily gain (ADG), faecal egg counts (FEC), plasma pepsinogen, combined FEC and plasma pepsinogen, versus random selection of individuals. Treatment success was assessed in terms of benefit per R (BPR), the ratio of average benefit in weight gain to change in frequency of resistance alleles R (relative to an untreated population). The optimal indicator in terms of BPR for fixed percentages of calves treated was plasma pepsinogen and the worst ADG; in the latter case treatment was applied to some individuals who were not in need of treatment. The reverse was found when calves were treated according to threshold criteria, with ADG being the best target indicator for treatment. This was also the most beneficial strategy overall, with a significantly higher BPR value than any other strategy, but its degree of success depended on the chosen threshold of the indicator. The study shows strong support for TST, with all strategies showing improvements on calves treated selectively, compared with whole-herd treatment at 3, 8, 13 weeks post-turnout. The developed model appeared capable of assessing the consequences of other TST strategies on calf populations.

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Section: Discussionmentioning

confidence: 99%

Modelling the consequences of targeted selective treatment strategies on performance and emergence of anthelmintic resistance amongst grazing calves

Berk

Laurenson

Forbes

et al. 2016

International Journal for Parasitology: Drugs and Drug Resistan

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“…The WEC test is promoted by government and nongovernment agencies in many commercialised small ruminant industries (Table 1). WEC has many technical disadvantages (Section 2.1) and poor adoption rates by farmers and is, therefore, considered an underutilised diagnostic in many small ruminant production systems [17]. As such, substantial research is being undertaken to find a more usable and accurate measure of infection intensity to assist the development and adoption of sustainable GIN parasite control programs.…”

Section: Ideal Characteristics Of Diagnostic Markers For Gin Parasmentioning

confidence: 99%

“…This is an exciting development particularly its potential to identify GIN parasite resistant to anthelmintic classes directly from the faeces as farmers perceive the current protocol to detect anthelmintic resistance involving mini-sheep trials as too difficult and time-consuming [17]. …”

Section: Ideal Characteristics Of Diagnostic Markers For Gin Parasmentioning

confidence: 99%

Current Status for Gastrointestinal Nematode Diagnosis in Small Ruminants: Where Are We and Where Are We Going?

Preston

Sandeman

González

et al. 2014

Journal of Immunology Research

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Gastrointestinal nematode (GIN) parasites pose a significant economic burden particularly in small ruminant production systems. Anthelmintic resistance is a serious concern to the effective control of GIN parasites and has fuelled the focus to design and promote sustainable control of practices of parasite control. Many facets of sustainable GIN parasite control programs rely on the ability to diagnose infection both qualitatively and quantitatively. Diagnostics are required to determine anthelmintic efficacies, for targeted treatment programs and selection of animals for parasite resistant breeding. This review describes much of the research investigated to date to improve the current diagnostic for the above practices which is based on counting the number of parasite eggs in faeces.

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“…However, advances in precision agriculture, such as automated assessment of liveweight (Laca, 2009), may make the measurement of such traits more straightforward and perhaps less time consuming. There are several potential bottlenecks for the adoption of TST in livestock, one of which being the increased costs that might be associated with their implementation (Woodgate and Love, 2012, Charlier et al, 2014). This study provides strong support for the targeted control of parasitism; however, further work involving a cost-benefit analysis may prove useful in convincing cattle farmers of the long-term benefits of such TST strategies.…”

Section: Discussionmentioning

confidence: 99%

Modelling the impacts of pasture contamination and stocking rate for the development of targeted selective treatment strategies for Ostertagia ostertagi infection in calves

Berk

Laurenson

Forbes

et al. 2017

Veterinary Parasitology

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HighlightsStocking rate effect on design of targeted selective treatments (TST) was evaluated.Initial pasture contamination effect on the design of TST was evaluated.Different phenotypic traits and methods of selection for treatment were addressed.Benefit was assessed as weight gain/frequency of resistant alleles in helminths.Treatment according to threshold triggers of average daily gain was most beneficial.

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WormKill to WormBoss—Can we sell sustainable sheep worm control?

Cited by 36 publications

References 27 publications

Modelling the consequences of targeted selective treatment strategies on performance and emergence of anthelmintic resistance amongst grazing calves

Modelling the consequences of targeted selective treatment strategies on performance and emergence of anthelmintic resistance amongst grazing calves

Current Status for Gastrointestinal Nematode Diagnosis in Small Ruminants: Where Are We and Where Are We Going?

Modelling the impacts of pasture contamination and stocking rate for the development of targeted selective treatment strategies for Ostertagia ostertagi infection in calves

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