Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

The role of microenvironment in the initiation and evolution of B-cell precursor acute lymphoblastic leukemia

“…Modern response-adapted multiagent chemotherapy regimens can cure the majority of children, albeit at the expense of toxicity ( 7 , 8 ). Treatment of adult B-ALL, however, is more challenging with approximately 50% overall survival even in patients fit enough to undergo allogeneic bone marrow transplantation ( 9 , 10 ). Introduction of novel targeted therapies (e.g.…”

Electrochemical and Optical Sensors for the Detection of Chemical Carcinogens Causing Leukemia

“…The classic division of leukemias includes: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL) [ 2 ]. ALL is the most common type of leukemia in children [ 3 ]. The incidence of ALL decreases in direct proportion to age [ 3 ].…”

“…ALL is the most common type of leukemia in children [ 3 ]. The incidence of ALL decreases in direct proportion to age [ 3 ]. The adult population has a higher incidence of chronic types of leukemia, and men are reported to be more likely to suffer from it due to the increased occupational exposure to carcinogens [ 4 ].…”

“…In 2020, the incidence of leukemia was the highest in North America, Australia, and New Zealand, followed by Europe and Western Asia. Available studies indicate a higher incidence of leukemia in industrialized, highly developed countries, which may be caused by both better access to the health care system and greater environmental pollution [ 1 , 3 , 6 , 7 ]. The exception is ALL, which is most common in South and Central America [ 1 ].…”

Impact of Center-related Characteristics and Macroeconomic Factors on the Outcome of Adult Patients With Acute Lymphoblastic Leukemia Treated With Pediatric-inspired Protocols

“…Diagnosis and treatment of hematological cancers is usually provided in many healthcare facilities including large but also middle size centers. 1 Providing cancer care in local institutions might be advantageous for patients and caregivers in terms of financial burden and quality of life. However, it might carry potential risks derived of the limited experience of smaller centers and differences in accessibility to complex therapies including allogeneic hematopoietic cell transplantation (allo-HCT) and chimeric antigen receptor (CAR) T-cells.…”