Worldwide trends in antimicrobial resistance among common respiratory tract pathogens in children

Jacobs, Michael

doi:10.1097/00006454-200308001-00002

Cited by 89 publications

(56 citation statements)

References 97 publications

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“…The rate of isolation of ␤-lactamase-producing H. influenzae strains has steadily increased over the last decades and has not decreased since the introduction of conjugate vaccines. The rates of isolation of ␤-lactamase-producing strains vary worldwide and are 4% in Russia, 15% in the United Kingdom, 26% in the United States, 31% in France, and 42% in Spain (159,186,218). For nontypeable strains, this rate is substantially higher, at 42%, in the United States (136).…”

Section: Haemophilus Influenzaementioning

confidence: 99%

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

2010

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SUMMARY The epidemiology of bacterial meningitis has changed as a result of the widespread use of conjugate vaccines and preventive antimicrobial treatment of pregnant women. Given the significant morbidity and mortality associated with bacterial meningitis, accurate information is necessary regarding the important etiological agents and populations at risk to ascertain public health measures and ensure appropriate management. In this review, we describe the changing epidemiology of bacterial meningitis in the United States and throughout the world by reviewing the global changes in etiological agents followed by specific microorganism data on the impact of the development and widespread use of conjugate vaccines. We provide recommendations for empirical antimicrobial and adjunctive treatments for clinical subgroups and review available laboratory methods in making the etiological diagnosis of bacterial meningitis. Finally, we summarize risk factors, clinical features, and microbiological diagnostics for the specific bacteria causing this disease.

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Section: Haemophilus Influenzaementioning

confidence: 99%

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

2010

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“…In Sweden, as in many other countries, ampicillin is the main drug of choice in proven H. influenzae infections and the primary empirical treatment choice for respiratory tract infections, where H. influenzae can be suspected. Ampicillin resistance in H. influenzae is now globally widespread, with incidence rates varying from 8 to 30% in different European countries and North America to more than 50% in some East Asian countries (12,13).…”

mentioning

confidence: 99%

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

Resman

Ristovski

Forsgren

et al. 2012

Antimicrob Agents Chemother

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ABSTRACTThe proportions ofHaemophilus influenzaeresistant to ampicillin and other β-lactam antibiotics have been low in Sweden compared to other countries in the Western world. However, a near-doubled proportion of nasopharyngeal SwedishH. influenzaeisolates with resistance to β-lactams has been observed in the last decade. In the present study, the epidemiology and mechanisms of antimicrobial resistance ofH. influenzaeisolates from blood and cerebrospinal fluid in southern Sweden from 1997 to 2010 (n= 465) were studied. Antimicrobial susceptibility testing was performed using disk diffusion, and isolates with resistance to any tested β-lactam were further analyzed in detail. We identified a significantly increased (P= 0.03) proportion of β-lactam-resistant invasiveH. influenzaeduring the study period, which was mainly attributed to a significant recent increase of β-lactamase-negative β-lactam-resistant isolates (P= 0.04). Furthermore, invasive β-lactamase-negative β-lactam-resistantH. influenzaeisolates from 2007 and onwards were found in higher proportions than the corresponding proportions of nasopharyngeal isolates in a national survey. Multiple-locus sequence typing (MLST) of this group of isolates did not completely separate isolates with different resistance phenotypes. However, one cluster of β-lactamase-negative ampicillin-resistant (BLNAR) isolates was identified, and it included isolates from all geographical areas. A truncated variant of a β-lactamase gene with a promoter deletion,blaTEM-1-PΔ dominated among the β-lactamase-positiveH. influenzaeisolates. Our results show that the proportions of β-lactam-resistant invasiveH. influenzaehave increased in Sweden in the last decade.

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“…Antibiotic resistance in both hospital and community settings is steadily increasing, severely limiting the effectiveness of all currently used classes of antibiotics (4,12,17). Approximately 50% of Staphylococcus aureus hospital isolates are methicillin resistant, while 30% of enterococci are reported to be vancomycin resistant (4).…”

mentioning

confidence: 99%

In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class

Mani

Gross

Parsons

et al. 2006

Antimicrob Agents Chemother

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Worldwide trends in antimicrobial resistance among common respiratory tract pathogens in children

Cited by 89 publications

References 97 publications

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class

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