Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys

Asher, M. Innes; Montefort, Stephen; Björkstén, Bengt; Lai, Christopher; Strachan, David P.; Weiland, Stephan K.; Williams, Hywel C

doi:10.1016/s0140-6736(06)69283-0

Cited by 3,621 publications

(3,075 citation statements)

References 28 publications

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“…1 The prevalence of atopy-related diseases in childhood has risen since the latter part of the 20th century. 2,3 The pathogenesis and etiology of atopy are very complex and not completely understood. Although environmental factors may contribute to atopy, 4 several family studies have indicated that genetic factors influence the risk of atopy.…”

mentioning

confidence: 99%

A synonymous variation in protease-activated receptor-2 is associated with atopy in Korean children

Lee

Kim

Gee

et al. 2011

Journal of Allergy and Clinical Immunology

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mentioning

confidence: 99%

A synonymous variation in protease-activated receptor-2 is associated with atopy in Korean children

Lee

Kim

Gee

et al. 2011

Journal of Allergy and Clinical Immunology

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“…The newer antihistamines, developed with the aim of being more specific for the histamine H [1] receptor and of overcoming these adverse effects, are clinically efficacious for alleviating symptoms of allergic rhinitis that are attributed to the earlyphase reaction, such as rhinorrhea, pruritus, and sneezing. However, they have demonstrated poor efficacy in controlling nasal congestion, which is related to the late-phase reaction.…”

Section: Discussionmentioning

confidence: 99%

“…Allergic rhinitis (AR) is a global health problem that has increased rapidly in prevalence over the past few decades [1]. The disease is now expected to affect more than 500 million individuals worldwide.…”

Section: Introductionmentioning

confidence: 99%

Nasal obstruction as a key symptom in allergic rhinitis: efficacy and safety of a medical device in children

Passàli

Bellussi

Gregori

et al. 2012

Otolaryngologia Polska

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Allergic rhinitis (AR) is a global health problem that has increased rapidly in prevalence over the past few decades. Nasal congestion, which represents a cardinal symptom of AR, appears to be difficult to treat and, especially for pediatric population, therapies that are both well tolerated and effective in relieving nasal congestion are needed. The aim of the present study was to evaluate the safety and clinical effectiveness of the medical device (lactoferrin, carboximetil β-glucan, D-panthenol, dipotassium glycyrrhizinate) in reducing the allergic rhinitis symptoms

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“…The prevalence of allergic rhinitis (AR) has increased both globally1 and in Japan2. The prevalence of seasonal allergic rhinitis (SAR) caused by Japanese cedar (JC) has increased over the past 10 years and is now estimated to affect up to 26% of the Japanese population, according to nationwide surveillance data2.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Hashiguchi

Kanzaki

Wakabayashi

et al. 2013

Journal of Drug Assessment

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ObjectiveThis study investigated the clinical efficacy of a combination therapy of levocetirizine (LCTZ) and fluticasone furoate nasal spray (FFNS), compared with LCTZ monotherapy, for the suppression of seasonal allergic rhinitis (SAR) symptoms induced in an artificial exposure chamber.MethodsThis study was a single-center, placebo-controlled, randomized, 3-way cross-over comparative study performed in 42 Japanese cedar pollinosis patients. These subjects received (1) LCTZ plus FFNS (combination group), (2) LCTZ plus FFNS placebo (monotherapy group), or (3) LCTZ placebo plus FFNS placebo (placebo group) once on the night prior to exposure, with a 1-week washout period between exposures. Nasal (sneezing, rhinorrhea, nasal congestion, and itchy nose) and ocular (eye itching and tearing) symptoms were recorded every 15 min, and the number of sneezes, nose blowing events, and the amount of nasal secretions were measured during exposure. The primary end-point was the cumulative incidence of SAR symptoms during exposure and the ‘ime to occurrence of symptoms’. The secondary end-points were the total nasal symptom score, the ocular symptom score, the amount of nasal discharge, and the number of sneezes and nose blowing events.ResultsAt all the measurement points, the lowest cumulative incidences for the nasal symptoms were observed in the combination group, followed by the monotherapy and placebo groups. All the subjects in the placebo group developed nasal symptoms within 2 h after pollen exposure, while three and eight subjects in the monotherapy and combination groups, respectively, did not develop any nasal symptoms during exposure. In addition, combination therapy delayed the onset of symptoms.ConclusionsThe results demonstrated that combination therapy with FFNS and LCTZ significantly suppressed the induced SAR symptoms and delayed the onset of symptoms compared with LCTZ monotherapy and placebo. Although the conditions of the allergen challenge study using an exposure chamber are different from those in real life, combination therapy with FF and LCTZ was confirmed to be an effective treatment for SAR.

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Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys

Cited by 3,621 publications

References 28 publications

A synonymous variation in protease-activated receptor-2 is associated with atopy in Korean children

A synonymous variation in protease-activated receptor-2 is associated with atopy in Korean children

Nasal obstruction as a key symptom in allergic rhinitis: efficacy and safety of a medical device in children

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

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