Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis

Human papillomavirus (HPV) is a major cause of cervical cancer. More than 100 HPV genotypes have been identified; however the distribution varies geographically and according to ethnicity. The purpose of this study was to investigate the prevalence and distribution of HPV subtypes among Northeast Thai women. Subjects included 198 cases of SCCA and 198 age-matched, healthy controls. HPV-DNA was amplified by PCR using the consensus primers GP5+/6+ system followed by reverse line blot hybridization genotyping. The prevalence of high-risk HPV infection was 21 (

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Genotypes and Cervical Cancer in Northeast Thailand

Natphopsuk¹,

Settheetham-Ishida²,

Pientong³

et al. 2013

“…A meta-analysis results of 157,879 women from 36 countries and regions, showed that HPV infection rate of the global women with normal cytology was 10.4%, which is 8.0% in Asia (de Sanjose et al, 2007;Zou et al, 2011). Pandey et al performed a human papillomavirus screening in north Indian women, and they reported that the HPV incidence in their study was 11.7% (Pandey et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Genotype Distribution and Behavioral Risk Factor Analysis of Human Papillomavirus Infection in Uyghur Women

Sui¹,

Jiao²,

Niyazi³

et al. 2013

We investigated the distribution of HPV genotypes in Uyghur women in Xinjiang region of China, and behavioral factors which could predispose them to HPV infection. In this cross-sectional study, women aged 15-59 years were recruited by cluster sampling method in Yutian region in 2009. Liquid-based cytology samples were analyzed centrally for HPV genotype with a linear array detector. Univariate and multivariate logistic regression analyses were performed to identify behavioral risk factors for HPV infection. A total of 883 Uyghur women were recruited successfully. The prevalence of high-risk HPV and low-risk HPV were 7.25% and 1.58%, respectively; the most common HPVs were HPV16, 51, 31, 39 and 58. We found that age of first sexual intercourse was a strong predictor for HPV infection (odds ratio of 4.01 for ≤ 15 years versus ≥25). Having sexual partners ≥ 3 was the second predictor (OR 3.69, 95% CI 2.24-7.16). Cleaning the vagina after sex showed an increased risk of HPV infection (OR 2.72; 95% CI 1.98-5.13); Using the condom showed protective factors for HPV infection (OR 0.36; 95%CI0.12-0.53). HPV16, 51, 31, 39 and 58 were the priority types; the age of first sexual intercourse was identified as a major risk factor for HPV infection. Other notable risks were number of sexual partners and cleaning the vagina after sex. Changing these behavioral risk factors could help to reduce the occurrence of cervical cancer in this population.

“…Currently very few HPV vaccines; Gardasil (HPV6/11/16/18) (Villa et al, 2005) and Cervarix (HPV16/18) (Harper et al, 2004) were developed against these two major cancer-causing HPV types (Yoshikawa, 2009). Based on the meta-analysis reported worldwide, HPV type 16 and 18 were the most common while in (de Sanjose et al, 2007;Bruni et al, 2010), HPV type 45, 31 and 33, were in Europe and Africa. HPV 52 and 58 presented a more frequent prevalence in Asia (Bao et al, 2008;Sun et al, 2010;.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus in Women from Saudi Arabia

Turki¹,

Sait²,

Anfinan³

et al. 2013

Background: Human papillomavirus (HPV) infection is the main causes of cervical cancer in women worldwide. The goal of the present study was to determine the prevalence and distribution of HPV genotypes in women from Saudi Arabia. Recently, several HPV detection methods have been developed, each with different sensitivities and specificities. Methods: In this study, total forty cervical samples were subjected to polymerase chain reaction and hybridization to BioFilmChip microarray assessment. Results: Human papillomavirus (HPV) infections were found in 43% of the specimens. The most prevalent genotypes were HPV 16 (30%) HPV 18 (8.0%) followed by type HPV 45, occurring at 5.0%. Conclusion: Our finding showed the HPV infection and prevalence is increasing at alarming rate in women of Saudi Arabia. There was no low risk infection detected in the tested samples. The BioFilmChip microarray detection system is highly accurate and suitable for detection of single and multiple infections, allowing rapid detection with less time-consumption and easier performance as compared with other methods.