Worldwide human daily intakes of bisphenol A (BPA) estimated from global urinary concentration data (2000–2016) and its risk analysis

Huang, Ri-ping; Liu, Ze‐hua; Yuan, Shuai; Yin, Hua; Dang, Zhi; Wu, Pingxiao

doi:10.1016/j.envpol.2017.06.026

Cited by 166 publications

(69 citation statements)

References 62 publications

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“…The average global EDI for the children was 60.08 ng/kg bw/ day in their study with the highest estimated child BPA daily intake found in Taiwan at 201.00 ng/kg bw/day, whereas Italy had the lowest with 15.34 ng/kg bw/day. The European Commission estimated the daily intake of BPA to be 0.4 μg/kg bw/day for adults, 1.2 μg/kg bw/day for children between 4 and 6 years, and 1.6 μg/kg bw/day for infants in EU countries(28). In our study, we detected half of the mean global value reported by Huang et al (28) (35 ng/kg bw/day).…”

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confidence: 50%

“…et al(28) calculated the average global EDI of BPA for children based on the results of studies of children aged between 2-17 years from 18 nations between 2000 and 2016. The average global EDI for the children was 60.08 ng/kg bw/ day in their study with the highest estimated child BPA daily intake found in Taiwan at 201.00 ng/kg bw/day, whereas Italy had the lowest with 15.34 ng/kg bw/day.…”

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confidence: 99%

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Assessment of Bisphenol A Levels in Preschool Children: Results of a Human Biomonitoring Study in Ankara, Turkey

Çok¹,

İkidağ²,

Battal³

et al. 2020

Jcrpe

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Objective: There is general concern regarding environmental chemical exposure and the impact it may have on human health. This is particularly important for vulnerable populations such as infants and children during critical periods of development. Bisphenol A (BPA) is an endocrine disrupting chemical used worldwide over the last 30 years in many consumer products. Evidence points to widespread human exposure to BPA. The aim of this study was to evaluate the exposure of Turkish preschool children to BPA. Methods: This study was conducted as a preliminary investigation of BPA in urine, collected from 3-6 year old children living in Ankara. After spot urine samples were taken from preschool children, free BPA, β-D-glucuronide and total BPA were determined using highperformance liquid chromatography tandem mass spectrometry and adjusted by creatinine concentration. Results: Preschool children from Ankara (n=125; males n=70, females n=55; mean age: 4.50±1.26) were recruited. BPA was detected in 76.8% of children from Ankara city, with urinary concentrations ranging from < limit of quantification to 18.36 µg/g creatinine. Total BPA levels were not statistically different between boys (1.26 µg/g creatinine) and girls (2.24 µg/g creatinine) (p>0.05). Conclusion: This study is an important contribution to the limited information about childhood exposure to BPA. The estimated daily BPA intake in this study is substantially lower than the European Food Safety Authority derived tolerable daily intake of 4 µg/kg BW/day. Abstract 86 J Clin Res Pediatr Endocrinol 2020;12(1):86-94

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confidence: 50%

mentioning

confidence: 99%

Assessment of Bisphenol A Levels in Preschool Children: Results of a Human Biomonitoring Study in Ankara, Turkey

Çok¹,

İkidağ²,

Battal³

et al. 2020

Jcrpe

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“…Nevertheless, the dietary ingestion of free BPA accounts for its major route of exposure. The daily uptake rate of BPA for humans is estimated to be 50 ng/kg bw/day [42]. It was found to prevail in diverse human tissues and body fluids [43].…”

Section: Introductionmentioning

confidence: 99%

Plastics in Cyanobacterial Blooms—Genotoxic Effects of Binary Mixtures of Cylindrospermopsin and Bisphenols in HepG2 Cells

Hercog

Štern

Maisanaba

et al. 2020

Toxins

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Ever-expanding environmental pollution is causing a rise in cyanobacterial blooms and the accumulation of plastics in water bodies. Consequently, exposure to mixtures of cyanotoxins and plastic-related contaminants such as bisphenols (BPs) is of increasing concern. The present study describes genotoxic effects induced by co-exposure to one of the emerging cyanotoxins—cylindrospermopsin (CYN)—(0.5 µg/mL) and BPs (bisphenol A (BPA), S (BPS), and F (BPF); (10 µg/mL)) in HepG2 cells after 24 and 72 h of exposure. The cytotoxicity was evaluated with an MTS assay and genotoxicity was assessed through the measurement of the induction of DNA double strand breaks (DSB) with the γH2AX assay. The deregulation of selected genes (xenobiotic metabolic enzyme genes, DNA damage, and oxidative response genes) was assessed using qPCR. The results showed a moderate reduction of cell viability and induction of DSBs after 72 h of exposure to the CYN/BPs mixtures and CYN alone. None of the BPs alone reduced cell viability or induced DSBs. No significant difference was observed between CYN and CYN/BPs exposed cells, except with CYN/BPA, where the antagonistic activity of BPA against CYN was indicated. The deregulation of some of the tested genes (CYP1A1, CDKN1A, GADD45A, and GCLC) was more pronounced after exposure to the CYN/BPs mixtures compared to single compounds, suggesting additive or synergistic action. The present study confirms the importance of co-exposure studies, as our results show pollutant mixtures to induce effects different from those confirmed for single compounds.

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“…Investigations of the conceivable impacts of BPA exposure have shown that constant exposure of BPA can cause toxicity in all organs of the body through the accumulation of oxidative stress (Huang et al, ). BPA exposure is known to impose severe effects including infertility and malformation in the genital tract (Colborn, Saal, & Soto, ; Li, Zhou, et al, ; Li, Song, et al, ; Vrooman, Oatley, Griswold, Hassold, & Hunt, ).…”

Section: Introductionmentioning

confidence: 99%

Alleviating impact of hydroethanolicMurraya koenigiileaves extract on bisphenol A instigated testicular lethality and apoptosis in mice

et al. 2020

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Bisphenol A (BPA) is a well‐known endocrine disruptor that imposees adverse effects on male fertility via interacting with germ cells of testis. Objectives of present study were to investigate the possible protective effects of hydroethanolic Murraya koenigii leaves extract (HEMKLE) against BPA‐induced testicular damage and apoptosis in mice. Male Balb/c mice were divided into four different groups: Group I (control), Group II (HEMKLE), Group III (BPA) and Group IV (HEMKLE + BPA). Group III (BPA) showed significant decrease in sperm parameters, germ cell number along with increased lipid peroxidation (LPO) and reactive oxygen species (ROS). A significant decrease in antioxidant enzymes activity was also observed in Group III (BPA) animals. mRNA expression study revealed significant decrease in the expression of Bcl‐2 and increase in expressions of caspase‐9 and caspase‐3, thus clearly demonstrate BPA‐induced apoptosis. In addition, HEMKLE co‐administration to BPA‐treated mice showed a significant increase in sperm parameters, germ cell number, decreased levels of LPO and ROS, increased antioxidant enzymes activity in Group IV (HEMKLE + BPA). Also, mRNA expression study showed a significant increase in Bcl‐2 and decrease in caspase‐9 and caspase‐3 gene expressions in Group IV (HEMKLE + BPA). Thus, the present study suggests that HEMKLE intervention provides protection against BPA‐induced oxidative stress and apoptosis.

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Worldwide human daily intakes of bisphenol A (BPA) estimated from global urinary concentration data (2000–2016) and its risk analysis

Cited by 166 publications

References 62 publications

Assessment of Bisphenol A Levels in Preschool Children: Results of a Human Biomonitoring Study in Ankara, Turkey

Assessment of Bisphenol A Levels in Preschool Children: Results of a Human Biomonitoring Study in Ankara, Turkey

Plastics in Cyanobacterial Blooms—Genotoxic Effects of Binary Mixtures of Cylindrospermopsin and Bisphenols in HepG2 Cells

Alleviating impact of hydroethanolicMurraya koenigiileaves extract on bisphenol A instigated testicular lethality and apoptosis in mice

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