Worldwide Experience with Bacampicillin Administered Twice a Day

Craig, William A.; Gerber, Andreas

doi:10.1093/clinids/3.1.171

Cited by 6 publications

References 14 publications

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Intrarenal Concentration‐Time Profile of Ampicillin After Administration of Bacampicillin to Patients Before Nephrectomy

Seppänen

Hällström

Sjövall³

et al. 1986

The Journal of Clinical Pharma

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Nineteen patients with renal cancer who were to undergo nephrectomy received a single oral dose of bacampicillin 800 mg at approximately three (N = 5), six (N = 7), or nine (N = 7) hours before nephrectomy. Serum samples were taken at 30, 60, and 90 minutes after administration and at nephrectomy. Urine was collected immediately before operation. Samples of medulla and cortex tissues were immediately and carefully dissected from a healthy part of the removed kidney and homogenized with a buffer solution. All concentrations were determined by bioassay. Bacampicillin was well absorbed, with a mean +/- SD serum concentration of 16.0 +/- 11.4 mg/L at one hour. The concentrations in renal tissues were higher than the serum levels taken at the same time, and the highest concentrations were found in the urine. the mean ampicillin elimination half-life was approximately the same in the cortex, medulla, and urine, (2.7, 2.3, and 2.4 hr, respectively) but it was shorter in the serum (1.4 hr). Bacampicillin 800 mg produced concentrations in the renal tissues that were higher and more sustained than in the serum and were well above the minimum inhibitory concentrations for common urinary pathogens even ten hours after the dose.

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Intrarenal Concentration‐Time Profile of Ampicillin After Administration of Bacampicillin to Patients Before Nephrectomy

Seppänen

Hällström

Sjövall³

et al. 1986

The Journal of Clinical Pharma

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Bacampicillin Hydrochloride: Chemistry, Pharmacology, and Clinical Use

Scheife

Neu

1982

Pharmacotherapy

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Bacampicillin hydrochloride is an orally administered ester of ampicillin that is rapidly and completely hydrolyzed in vivo to ampicillin. The most notable advantage of bacampicillin over ampicillin is its superior bioavailability--bacampicillin achieves significantly higher blood and tissue levels and attains peak blood levels more rapidly than equimolar doses of oral ampicillin. In addition, the percentage of an oral dose of ampicillin that is absorbed decreases sharply as the size of the dose is increased from 500 mg to 2 g; this phenomenon is not observed with equipotent doses of bacampicillin. The enhanced absorption of bacampicillin in the upper gastrointestinal tract results in a frequency of diarrhea that appears to be markedly lower than that of ampicillin and similar to that observed with amoxicillin. Apart from the sizable differences between bacampicillin and ampicillin with regard to oral absorption, the pharmacokinetic and pharmacologic profiles of these two agents are essentially identical. Twice daily dosing (pulse dosing) with bacampicillin has been shown in numerous clinical trials to be of equivalent efficacy to ampicillin given four times daily or amoxicillin given three times daily in the treatment of infections of the upper respiratory tract, lower respiratory tract, skin and soft tissues, and urinary tract. The unanswered question is whether twice daily ampicillin or amoxicillin would yield similar results.

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Drug Eruptions

Krebs

1988

Dermatology in Five Continents

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Worldwide Experience with Bacampicillin Administered Twice a Day

Cited by 6 publications

References 14 publications

Intrarenal Concentration‐Time Profile of Ampicillin After Administration of Bacampicillin to Patients Before Nephrectomy

Intrarenal Concentration‐Time Profile of Ampicillin After Administration of Bacampicillin to Patients Before Nephrectomy

Bacampicillin Hydrochloride: Chemistry, Pharmacology, and Clinical Use

Drug Eruptions

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