Worldwide epidemiology of neuro-coronavirus disease in children: lessons for the next pandemic

Alcamo, Alicia M.; McGuire, Jennifer L.; Kanthimathinathan, Hari Krishnan; Roa, Juan David; Fink, Ericka L.

doi:10.1097/mop.0000000000001069

Cited by 7 publications

(21 citation statements)

References 90 publications

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“…[ 24 , 26 , 56 , 57 ] However, a study reported that the frequency of seizures increased in young children, occurring at a rate of 38% under the age of 5 years. [ 11 ] Our study findings are inconsistent with literature reports as most of our patients were over 9 years. In addition; the number of children below 2 years was equal to the number of children above 9 years in the seizure group.…”

Section: Discussioncontrasting

confidence: 99%

“…Notably, neurological findings are more common in obese patients in the literature. [6,9–12,15,23,26,53–55]…”

Section: Discussionmentioning

confidence: 99%

“…[6,[9][10][11][12]15,23,26,[53][54][55] Reports show that seizures are observed more frequently in patients with underlying neurological disease and/or hospitalised for severe illness. [6,[9][10][11][12]15,23,26,[53][54][55] Unlike the literature, in our study, the number of boys (n:13, 37.1%) was slightly smaller than the number of girls (n:22, 62.9%) in Group 1. Most studies have reported that there is no gender difference in terms of neurological findings among children.…”

Section: Discussionmentioning

confidence: 99%

“…[7,9,[11][12][13]23,24,26,30,31] Evaluation of neurological manifestations according to age revealed that cerebrovascular events, encephalopathy, peripheral nervous system involvement and myelitis were more common in adults, while olfactory findings, seizures and headaches were more common in the pediatric age group. [9][10][11][12][13][14]23,24,26,[32][33][34][35][36][37][38][39][40][41] The long-term impact of COVID-19 infection on the CNS in children remains unclear. Reports on the neurological effects of COVID-19 in adults and children are increasing day by day.…”

Section: Introductionmentioning

confidence: 99%

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Neurological symptoms and signs associated with COVID-19 in pediatric patients: a single-center experience

Okur¹

2022

Medicine

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There is insufficient evidence on SARS-CoV-2 induced neurological effects. Studies on CNS involvement during COVID-19 in children are limited. This study aims to identify and manage the neurological signs and symptoms in COVID-19-infected pediatric patients during follow up and plan future follow-ups.Children diagnosed COVID-19 and hospitalized in the pediatric pandemic services, between March 18, 2020, and June 18, 2021, were included in the study. Children with underlying neurological disease were excluded from the study. Patient data retrieved from hospital files and medical records. Children divided into 2 groups, 1 and 2, based on the presence or absence of neurological findings.A total of 243 children received follow-ups in the pandemic wards, 35 (14.4%) of these patients had neurological findings. Major neurological manifestations were headache (n:17, 7%), seizure (n:4, 1.6%), and anosmia/hyposmia (n:17, 7%). The number of boys (n:13, 37.1%) was smaller than the number of girls (n:22, 62.9%) in Group 1. Group 1 showed higher blood leukocyte, lymphocyte, thrombocyte, AST, LDH, d-dimer values. Anosmia/hyposmia occurred more often in girls, anosmia and headache occurred more often over 9 years of age. Pulmonary and hematologic involvement was more common in children with anosmia and headache.Our study is one of the few studies on neurological involvement in COVID-19 in children. To the best of our knowledge, there is limited data on these subjects in the literature. Abbrevations: AST = aspartate aminotransferase, CK = creatine kinase, CNS = central nervous system, COVID-19 = new type of coronavirus disease, CRP = C-reactive protein, CT = computed tomography, LDH = lactate dehydrogenase, NIMV = noninvasive mechanical ventilation, PICU = pediatric intensive care unit, PCR = polymerase chain reaction, SPSS = Statistical Package for the Social Sciences, WHO = world health organization.

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Section: Discussioncontrasting

confidence: 99%

“…Notably, neurological findings are more common in obese patients in the literature. [6,9–12,15,23,26,53–55]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neurological symptoms and signs associated with COVID-19 in pediatric patients: a single-center experience

Okur¹

2022

Medicine

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“…Neurological symptoms have been identified in paediatric cases of COVID-19 [5], with approximately 22% of hospitalized children being affected by neurological manifestations such as smell/taste disorders, headache, and stroke [6]. Intracranial hypertension [7] and acute encephalitis [8] have also been reported in children with multisystem inflammatory syndrome.…”

Section: Introductionmentioning

confidence: 99%

Coronavirus infection in neonates: Neurodevelopmental outcomes at 18 months of age

Ayed¹,

Alsaffar

Bahzad

et al. 2022

Preprint

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Background: Although most neonates with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have mild disease, the impact on neurodevelopmental outcomes is unknown. This study aimed to assess 18-month neurodevelopmental outcomes of neonates infected with SARS-CoV-2 infection. Methods: We conducted a prospective cohort study of neonates diagnosed with SARS-CoV-2 infection between June to August 2020 through nasopharyngeal coronavirus disease 2019 (COVID-19) PCR testing. A total of 58 neonates were identified from the Kuwait national COVID-19 registry and were enrolled. Historical controls were selected from the neonatal follow-up registry and matched 2:1 based on sex and gestational age. At 18 months of age, neurodevelopmental outcomes were assessed using Bayley Scales of Infant and Toddler Development-3rd Edition (BSID-III) by two trained assessors. Results: A total of 40 children were diagnosed with SARS-CoV-2 infection and included in the final analysis. The median age at infection was 18 days (range: 10-26 days). Eighteen (45%) were asymptomatic, 15 (37.5%) had a sepsis-like presentation, 5 (12.5%) had respiratory distress and 2 (5%) had a multisystem inflammatory syndrome in children (MIS-C)-like presentation. At 18 months follow up, only one child had severe developmental delay, and one child had a language delay. BSID-III outcomes did not significantly differ between the SARS-CoV-2 infected group and the control group. Conclusions: There is no difference in neurodevelopmental outcomes in children infected with SARS-CoV-2 infection at 18 months compared to controls, although longer neurodevelopmental follow-up studies are required.

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Neuropsychological Impact of COVID-19 on Children and Adolescents

Koterba,

Vargas,

et al. 2023

J Pediatr Neuropsychol

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Worldwide epidemiology of neuro-coronavirus disease in children: lessons for the next pandemic

Cited by 7 publications

References 90 publications

Neurological symptoms and signs associated with COVID-19 in pediatric patients: a single-center experience

Neurological symptoms and signs associated with COVID-19 in pediatric patients: a single-center experience

Coronavirus infection in neonates: Neurodevelopmental outcomes at 18 months of age

Neuropsychological Impact of COVID-19 on Children and Adolescents

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