Worldwide Distribution, Risk Factors, and Temporal Trends of Testicular Cancer Incidence and Mortality: A Global Analysis

Huang, Junjie; Chan, Sze Chai; Tin, Man Sing; Liu, Xianjing; Lok, Veeleah; Zhang, Lin; Lucero‐Prisno, Don Eliseo; Xu, Wanghong; Zheng, Zhi‐Jie; Chiu, Peter Ka‐Fung; Ng, Adolf K.Y.; Enikeev, Dmitry; Nicol, David; Spiess, Philippe E.; Laguna, Pilar; Teoh, Jeremy Yuen‐Chun; Wong, Martin Cs

doi:10.1016/j.euo.2022.06.009

Cited by 32 publications

(26 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic factors do not fully explain this trend and it has been suggested that lifestyle and the environment in modern society may play an important role [ 10 ]. This concept has been supported by geographical differences in the incidences of testicular cancer, with some of the highest incidence rates observed in the Nordic countries ( Figure 1 ) [ 9 , 11 , 12 , 13 ], and moreover disproportionately affecting high-income countries more than that of low-income countries [ 9 , 14 ]. Furthermore, differential risks of the malignancy have been observed among first- and second-generation immigrants, reflecting the environment’s influence [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Testicular cancer is the growth of cancerous cells in the testis and predominantly affects young males aged 15 to 44 years [ 7 , 8 ]. The incidence of testicular cancer has increased worldwide during the past decades, with the causes unknown [ 9 ]. Genetic factors do not fully explain this trend and it has been suggested that lifestyle and the environment in modern society may play an important role [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several epidemiological studies have already linked maternal cigarette smoking with outcomes associated with testicular cancer, such as cryptorchidism and hypospadias [ 9 , 10 , 18 , 19 , 20 ], but the available evidence specifically on testicular cancer is rather sparse. The latest systematic review based on a literature search from 2013 concluded that there was no evidence of an association between maternal cigarette smoking and testicular cancer.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal Exposure to Cigarette Smoke during Pregnancy and Testicular Cancer in Offspring: A Systematic Review and Meta-Analysis

Beck

Bräuner

Hauser

et al. 2023

Life

View full text Add to dashboard Cite

Background: Maternal exposure to cigarette smoke in pregnancy may play a role in the development of testicular cancer in offspring. An updated and comprehensive systematic review of the available evidence is needed. Objective: To identify and evaluate current evidence on maternal exposure to cigarette smoke during pregnancy and testicular cancer in offspring. Methods: A systematic search of English peer-reviewed original literature in PubMed through a block search approach. Publications were considered if assessing maternal exposure to cigarette smoke and the risk of testicular cancer in offspring. Results: Among the 636 identified records, 14 publications were eligible for review and 10 for meta-analysis. Quality assessment of the publications was conducted. Most included publications were case-control studies (n = 11, 79%), while the remaining were ecological studies (n = 3, 21%). Completeness of reporting was high, but more than half were considered subject to potential bias. The trend synthesis showed that half (n = 7) of the included publications demonstrated a higher risk of testicular cancer in the sons of mothers exposed to cigarette smoke during pregnancy. The meta-analysis generated an overall summary risk estimate of 1.00 (95% CI: 0.88; 1.15) (n = 10 publications), with a lower risk for seminoma (0.79, 95% CI: 0.59; 1.04) and nonseminoma (0.96, 95% CI: 0.74; 1.26) (n = 4 publications). Conclusions: This systematic review did not provide evidence of an association between maternal exposure to cigarette smoke and risk of testicular cancer in offspring. An overall positive trend was suggested, but it had low statistical precision. The methodological limitations across publications encourage further research based on valid exposure data.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Exposure to Cigarette Smoke during Pregnancy and Testicular Cancer in Offspring: A Systematic Review and Meta-Analysis

Beck

Bräuner

Hauser

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…Another limitation is instead related to the fact that not all individuals with known risk factors for testicular cancer will actually develop the disease, highlighting the need for further research aimed at assessing the underlying mechanism which contributes to testis carcinogenesis. Lastly, the identification of risk factors alone could not predict high-risk individuals as many cases occur in individuals with no known risk factors [159,160]. A comprehensive approach that takes into account both epidemiologic and genetic risk factors is necessary to accurately assess individual risks of developing testicular cancer and, therefore, tailoring a proper screening.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Risk Factors for Testicular Cancer: Environment, Genes and Infections—Is It All?

Yazıcı

Biondo²,

Napodano³

et al. 2023

Medicina

View full text Add to dashboard Cite

The incidence of testicular cancer is steadily increasing over the past several decades in different developed countries. If on one side better diagnosis and treatment have shone a light on this disease, on the other side, differently from other malignant diseases, few risk factors have been identified. The reasons for the increase in testicular cancer are however unknown while risk factors are still poorly understood. Several studies have suggested that exposure to various factors in adolescence as well as in adulthood could be linked to the development of testicular cancer. Nevertheless, the role of environment, infections, and occupational exposure are undoubtedly associated with an increase or a decrease in this risk. The aim of this narrative review is to summarize the most recent evidence regarding the risk factors associated with testicular cancer, starting from the most commonly evaluated (cryptorchidism, family history, infections) to the newer identified and hypothesized risk factors.

show abstract

“…A total of 9910 new cases of testicular tumors were also diagnosed in the United States in 2022 (4). However, the reasons for this increase are not well documented (2,(5)(6)(7)(8). The causes of testicular tumors remain unclear, and studies have identified cryptorchidism, hypospadias, low sperm count, and genetics as risk factors (9).…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognostic factors in patients diagnosed with lymphovascular invasion of testicular germ-cell tumors: Analysis based on the SEER database

Jiang²,

He³

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundLymphovascular invasion (LVI) is a high-risk factor for testicular germ-cell tumors (TGCT), but a prognostic model for TGCT-LVI patients is lacking. This study aimed to develop a nomogram for predicting the overall survival (OS) of TGCT-LVI patients.MethodsA complete cohort of 3288 eligible TGCG-LVI patients (training cohort, 2300 cases; validation cohort, 988 cases) were obtained from the Surveillance, Epidemiology, and End Results database. Variables screened by multivariate Cox regression analysis were used to construct a nomogram, which was subsequently evaluated using the consistency index (C-index), time-dependent receiver operating characteristic curve (ROC), and calibration plots. The advantages and disadvantages of the American Joint Committee on Cancer (AJCC) staging system and the nomogram were assessed by integrated discrimination improvement (IDI) and net reclassification improvement (NRI). Decision-analysis curve (DCA) was used to measure the net clinical benefit of the nomogram versus the AJCC staging system. Finally, Kaplan–Meier curves were used to evaluate the ability to identify different risk groups between the traditional AJCC staging system and the new risk-stratification system built on the nomogram.ResultsNine variables were screened by multivariate Cox regression analysis to construct the nomogram. The C-index (training cohort, 0.821; validation cohort, 0.819) and time-dependent ROC of 3-, 5-, and 9-year OS between the two cohorts suggested that the nomogram had good discriminatory ability. Calibration curves showed good consistency of the nomogram. The NRI values of 3-, 5-, and 9-year OS were 0.308, 0.274, and 0.295, respectively, and the corresponding values for the validation cohort were 0.093, 0.093, and 0.099, respectively (P<0.01). Additionally, the nomogram had more net clinical benefit as shown by the DCA curves, and the new risk-stratification system provided better differentiation than the AJCC staging system.ConclusionsA prognostic nomogram and new risk-stratification system were developed and validated to assist clinicians in assessing TGCT-LVI patients.

show abstract

Worldwide Distribution, Risk Factors, and Temporal Trends of Testicular Cancer Incidence and Mortality: A Global Analysis

Cited by 32 publications

References 43 publications

Maternal Exposure to Cigarette Smoke during Pregnancy and Testicular Cancer in Offspring: A Systematic Review and Meta-Analysis

Maternal Exposure to Cigarette Smoke during Pregnancy and Testicular Cancer in Offspring: A Systematic Review and Meta-Analysis

Risk Factors for Testicular Cancer: Environment, Genes and Infections—Is It All?

Clinical features and prognostic factors in patients diagnosed with lymphovascular invasion of testicular germ-cell tumors: Analysis based on the SEER database

Contact Info

Product

Resources

About