Worldwide Correlations Support COVID-19 Seasonal Behavior and Impact of Global Change

Hernandez, Nicolas; Caetano‐Anollés, Gustavo

doi:10.1177/11769343231169377

Cited by 2 publications

(2 citation statements)

References 50 publications

(87 reference statements)

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“…SARS-CoV-2 reveals a seasonal behavior, which is generally in line with that seen for other respiratory viruses, such as influenza viruses and respiratory syncytial virus [ 177 , 178 , 179 ]. For example, in Europe and the United States, the highest SARS-CoV-2 burden, i.e., infections, emergency visits, hospitalizations, and deaths, can be expected between autumn and early spring [ 179 , 180 , 181 ].…”

Section: Simplifying Covid-19 Booster Vaccination Will Improve Vaccin...supporting

confidence: 71%

Key Considerations during the Transition from the Acute Phase of the COVID-19 Pandemic: A Narrative Review

Rzymski,

Pokorska-Śpiewak,

Jackowska

et al. 2023

Vaccines

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The COVID-19 pandemic has been met with an unprecedented response from the scientific community, leading to the development, investigation, and authorization of vaccines and antivirals, ultimately reducing the impact of SARS-CoV-2 on global public health. However, SARS-CoV-2 is far from being eradicated, continues to evolve, and causes substantial health and economic burdens. In this narrative review, we posit essential points on SARS-CoV-2 and its responsible management during the transition from the acute phase of the COVID-19 pandemic. As discussed, despite Omicron (sub)variant(s) causing clinically milder infections, SARS-CoV-2 is far from being a negligible pathogen. It requires continued genomic surveillance, particularly if one considers that its future (sub)lineages do not necessarily have to be milder. Antivirals and vaccines remain the essential elements in COVID-19 management. However, the former could benefit from further development and improvements in dosing, while the seasonal administration of the latter requires simplification to increase interest and tackle vaccine hesitancy. It is also essential to ensure the accessibility of COVID-19 pharmaceuticals and vaccines in low-income countries and improve the understanding of their use in the context of the long-term goals of SARS-CoV-2 management. Regardless of location, the primary role of COVID-19 awareness and education must be played by healthcare workers, who directly communicate with patients and serve as role models for healthy behaviors.

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Section: Simplifying Covid-19 Booster Vaccination Will Improve Vaccin...supporting

confidence: 71%

Key Considerations during the Transition from the Acute Phase of the COVID-19 Pandemic: A Narrative Review

Rzymski,

Pokorska-Śpiewak,

Jackowska

et al. 2023

Vaccines

View full text Add to dashboard Cite

show abstract

“…This fact is particularly important because a study of the impact of latitude and hemispheres on the rise of mutant constellations has linked the NTD to SARS-CoV-2 seasonal behavior [ 25 , 27 ]. Note that worldwide correlations and time-series correlation charts provide strong support for the seasonal behavior of COVID-19 throughout the pandemic [ 67 , 68 ]. This should not be considered surprising.…”

Section: Discussionmentioning

confidence: 99%

AlphaFold2 Reveals Structural Patterns of Seasonal Haplotype Diversification in SARS-CoV-2 Spike Protein Variants

Ali,

Caetano-Anollés

2024

Biology

Self Cite

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The slow experimental acquisition of high-quality atomic structures of the rapidly changing proteins of the COVID-19 virus challenges vaccine and therapeutic drug development efforts. Fortunately, deep learning tools such as AlphaFold2 can quickly generate reliable models of atomic structure at experimental resolution. Current modeling studies have focused solely on definitions of mutant constellations of Variants of Concern (VOCs), leaving out the impact of haplotypes on protein structure. Here, we conduct a thorough comparative structural analysis of S-proteins belonging to major VOCs and corresponding latitude-delimited haplotypes that affect viral seasonal behavior. Our approach identified molecular regions of importance as well as patterns of structural recruitment. The S1 subunit hosted the majority of structural changes, especially those involving the N-terminal domain (NTD) and the receptor-binding domain (RBD). In particular, structural changes in the NTD were much greater than just translations in three-dimensional space, altering the sub-structures to greater extents. We also revealed a notable pattern of structural recruitment with the early VOCs Alpha and Delta behaving antagonistically by suppressing regions of structural change introduced by their corresponding haplotypes, and the current VOC Omicron behaving synergistically by amplifying or collecting structural change. Remarkably, haplotypes altering the galectin-like structure of the NTD were major contributors to seasonal behavior, supporting its putative environmental-sensing role. Our results provide an extensive view of the evolutionary landscape of the S-protein across the COVID-19 pandemic. This view will help predict important regions of structural change in future variants and haplotypes for more efficient vaccine and drug development.

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Worldwide Correlations Support COVID-19 Seasonal Behavior and Impact of Global Change

Cited by 2 publications

References 50 publications

Key Considerations during the Transition from the Acute Phase of the COVID-19 Pandemic: A Narrative Review

Key Considerations during the Transition from the Acute Phase of the COVID-19 Pandemic: A Narrative Review

AlphaFold2 Reveals Structural Patterns of Seasonal Haplotype Diversification in SARS-CoV-2 Spike Protein Variants

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