World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a consensus study

Niklander, Sven; Simms, Melanie; Wiriyakijja, Paswach; Santos‐Silva, Alan Roger; Kuten-Shorrer, Michal; Sankar, Vidya; Kerr, Alexander Ross; Jensen, Siri Beier; Ríordáin, Rícheal Ní; Villa, Alessandro; Delli, Konstantina

doi:10.1016/j.oooo.2022.12.016

Cited by 5 publications

(1 citation statement)

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“…Although there is no standard measurement for evaluating xerostomia symptoms, a recent systematic review suggested that the XQ had the highest potential to be used as patient‐reported outcome measures for changes in radiation‐induced dry mouth (Assas et al., 2021). Moreover, a consensus study from the World Workshop on Oral Medicine VIII developed a consensus‐based core outcome set to assess dry mouth interventions in clinical trials (Niklander et al., 2023). Furthermore, the majority of previous studies focused on short‐term effects; the long‐term effects of the interventions should be investigated in future studies.…”

Section: Discussionmentioning

confidence: 99%

Non‐pharmacologic interventions for management of radiation‐induced dry mouth: A systematic review

Khamdi,

Matangkasombut,

Lam‐Ubol

2023

Oral Diseases

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ObjectivesRadiation‐induced dry mouth negatively impacts patients' oral health and quality of life. Currently, evidence‐based recommendation for non‐pharmacologic interventions is still lacking.This study aimed to systematically review clinical trials evaluating the efficacy of non‐pharmacologic interventions in cancer patients with radiation‐induced dry mouth.MethodsRandomized controlled trials from 2000 were searched from 4 databases, including MEDLINE, Cochrane, Embase via OVID, and SCOPUS, up to December 16th, 2022 (PROSPERO registration CRD42022378405). The risk of bias was assessed using the revised Cochrane risk of bias assessment tool.ResultsTwenty‐one studies were included: 11 on artificial saliva, 4 on electrical nerve stimulation (TENS), 2 on acupuncture, and one study each on low‐level laser therapy, stem cells, chewing gum, and probiotics. Overall bias was low, medium, and high in 33%, 48%, and 19% of the studies, respectively. Certain artificial saliva products and TENS were shown to improve dry mouth symptoms and salivary flow rate (SFR). One study showed that stem cell transplantation significantly increased SFR.ConclusionsThe evidence suggested that certain artificial saliva products and TENS are promising management. However, the evidence was still limited due to heterogeneity of interventions and outcome measurements. Thus, future studies using standard measurements and long‐term follow‐up are warranted.

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Section: Discussionmentioning

confidence: 99%