World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction

Aliko, Ardita; Wolff, Ändy; Dawes, C.; Aframian, Doron J.; Proctor, Gordon; Ekström, Jørgen; Narayana, Nagamani; Villa, Alessandro; Sia, Ying Wai; Joshi, Revan Kumar; McGowan, Richard; Jensen, Siri Beier; Kerr, Alexander Ross; Pedersen, Anne Marie Lynge; Vissink, Arjan

doi:10.1016/j.oooo.2014.10.027

Cited by 81 publications

(72 citation statements)

References 166 publications

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“…Dry mouth is one of the most common adverse effects of medication use in older adults . This includes salivary gland hypofunction (objectively measured decrease in salivation) and xerostomia (subjective feeling of dry mouth).…”

Section: Objectivementioning

confidence: 99%

“…This includes salivary gland hypofunction (objectively measured decrease in salivation) and xerostomia (subjective feeling of dry mouth). It has been shown that the prevalence of hyposalivation increases with the number of medications used, but few studies have investigated the severity of medication‐induced dry mouth and associated sequelae . Adverse effects of salivary gland hypofunction include dental caries, dysgeusia, oral mucosal soreness, and oral candidiasis .…”

Section: Objectivementioning

confidence: 99%

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Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis

Tan

Lexomboon

Sandborgh‐Englund

et al. 2017

J American Geriatrics Society

110

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OBJECTIVES:To assess and quantify the risk of druginduced dry mouth as a side effect in older people. DESIGN: Systematic review and metaanalysis. SETTING: A search of the literature was undertaken using Medline, Embase, Cochrane, Web of Science, and PubMed from 1990 to 2016. PARTICIPANTS: Older people (aged ≥60) who participated in intervention or observational studies investigating drug use as an exposure and xerostomia or salivary gland hypofunction as adverse drug outcomes. MEASUREMENTS: Two pairs of authors screened titles and abstracts of studies for relevance. Two authors independently extracted data, including study characteristics, definitions of exposure and outcome, and methodological quality. For the metaanalyses, random-effects models were used for pooling the data and I 2 statistics for exploring heterogeneity. RESULTS: Of 1,544 potentially relevant studies, 52 were deemed eligible for inclusion in the final review and 26 in metaanalyses. The majority of studies were of moderate methodological quality. In the intervention studies, urological medications (odds ratio (OR) = 5.91, 95% confidence interval (CI) = 4.04-8.63; I 2 = 62%), antidepressants (OR = 4.74, 95% CI = 2.69-8.32, I 2 = 21%), and psycholeptics (OR = 2.59, 95% CI = 1.79-3.95, I 2 = 0%) were significantly associated with dry mouth. In the observational studies, numbers of medications and several medication classes were significantly associated with xerostomia and salivary gland hypofunction. CONCLUSION:Medication use was significantly associated with xerostomia and salivary gland hypofunction in older adults. The risk of dry mouth was greatest for drugs used for urinary incontinence. Future research should develop a risk score for medication-induced dry mouth to assist with prescribing and medication management. J Am Geriatr Soc 66:76-84, 2018.

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Section: Objectivementioning

confidence: 99%

Section: Objectivementioning

confidence: 99%

Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis

Tan

Lexomboon

Sandborgh‐Englund

et al. 2017

J American Geriatrics Society

110

View full text Add to dashboard Cite

show abstract

“…3 Many factors have been associated with xerostomia. The most common causes are: 4,5,6,7,8,9 a. Medications (more than 400 drugs are associated with xerostomia as a side effect); b.…”

Section: Introductionmentioning

confidence: 99%

Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life

Niklander¹,

et al. 2017

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“…Poor oral hygiene increases the risk of developing progressive periodontal disease and dental decay. Moreover, polypharmacy, which is commonly seen in the elderly (Maher et al , ), can lead to an even higher risk of developing oral problems as polypharmacy is associated with oral dryness and increased risk of developing oral infections and rampant caries (Aliko et al , ). Dental and periodontal diseases have been associated with severe health problems including diabetes (Teeuw et al , ), cardiovascular disease (Janket et al , ), atherosclerosis (Friedlander et al , ), rheumatoid arthritis (de Smit et al , ), decreased kidney function (Iwasaki et al , ), pneumonia (Tada and Miura, ), multiple sclerosis, and other systemic immune problems (Somma et al , ).…”

Section: Introductionmentioning

confidence: 99%

Elderly with remaining teeth report less frailty and better quality of life than edentulous elderly: a cross‐sectional study

et al. 2017

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World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction

Cited by 81 publications

References 166 publications

Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis

Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis

Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life

Elderly with remaining teeth report less frailty and better quality of life than edentulous elderly: a cross‐sectional study

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