World-Wide Antibiotic Resistance in Methicillin-Resistant Staphylococcus Aureus

Maple, P. A. C.; Hamilton‐Miller, J. M. T.; Brumfitt, W.

doi:10.1016/s0140-6736(89)90076-7

Cited by 283 publications

(160 citation statements)

References 24 publications

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“…Extensive use and misuse of the available antibiotic arsenal and the shortage of new drugs reaching the market have made antimicrobial resistance a major threat to healthcare worldwide (Maple et al 1989). The continuous development of novel resistancedisrupting antimicrobial drugs should therefore be a prime activity of industry and academia (Rex 2014).…”

Section: Introductionmentioning

confidence: 99%

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

et al. 2014

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The antimicrobial drug candidate 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate (SBC3) was evaluated for its ability to function in vivo using larvae of Galleria mellonella. A SBC3 concentration of 25 lg/ml inhibited the growth of Staphylococcus aureus by 71.2 % and Candida albicans by 86.2 % in vitro. Larvae inoculated with 20 ll of SBC3 solution showed no ill effects up to a concentration of 250 lg/ml but administration of 500 lg/ml resulted in a 40 % reduction in larval survival and administration of a dose of 1,000 lg/ml resulted in total larval death at 24 h. Larvae inoculated with S. aureus or C. albicans and subsequently administered SBC3 showed increased survival. Administration of SBC3 to larvae did not boost the insect immune response as indicated by lack of an increase in the density of circulating haemocytes (immune cells). The abundance of a number of proteins involved in the insect immune response was reduced in larvae that received 20 ll SBC3 solution of 100 lg/ml. This is the first demonstration of the in vivo activity of SBC3 against S. aureus and C. albicans and demonstrates that SBC3 does not stimulate a non-specific immune response in larvae.

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Section: Introductionmentioning

confidence: 99%

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

et al. 2014

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“…aureus infections constitute a major health care problem because this pathogen has developed resistance to most antibiotics introduced in antibiotherapy. 1 Moreover, the nasal carriage of S. aureus/methicilin-resistant S. aureus (MrSA) is recognized as a risk factor for the acquisition of an endogenous infection and plays an important role in the spread of this pathogen not only in the hospital care units but in the community as well. 2 Data exist for different countries regarding S. aureus/MrSA infections, but in Africa and developing countries only a few reports are available.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Staphylococcus aureus infections and nasal carriage at the Ibn rochd university hospital center, casablanca, morocco

Zriouil¹,

Bekkali²,

Zerouali³

2012

Braz J Infect Dis

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Methicillin-resistantdetermined by the agar diffusion method, and methicillin resistance was confirmed by amplifying the mecA gene by polymerase chain reaction (Pcr). the prevalence of methicilin-resistant S. aureus (MrSA) was high in the burns (57.7%) and dermatology (39.4%) wards, and the MrSA strains isolated were extremely multi-resistant, but all of them were still susceptible to vancomycin. the rate of S. aureus nasal carriage was high in both cases and controls, in state, MrSA nasal carriage was more common among people infected with S. aureus.

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“…Once MRSA is introduced into a hospital it usually becomes endemic, despite the implementation of infection control measures [1,2] and is an important cause of nosocomial infection [2,3].…”

Section: Introductionmentioning

confidence: 99%

Spread of the Brazilian epidemic clone of a multiresistant MRSA in two cities in Argentina

Coimbra¹,

Teixeira²,

Ramos

et al. 2000

Journal of Medical Microbiology

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World-Wide Antibiotic Resistance in Methicillin-Resistant Staphylococcus Aureus

Cited by 283 publications

References 24 publications

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

Epidemiology of Staphylococcus aureus infections and nasal carriage at the Ibn rochd university hospital center, casablanca, morocco

Spread of the Brazilian epidemic clone of a multiresistant MRSA in two cities in Argentina

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