World Tuberculosis Day March 24th 2019 Theme: “It’s TIME” — International Journal of Infectious Diseases Tuberculosis Theme Series

Petersen, Eskild; Rao, Martin; Ippolito, Giuseppe; Gualano, Gina; Chakaya, Jeremiah; Ntoumi, Francine; Moore, David; Allen, Rhiannon; Gaskell, Katherine M; Öhd, Joanna Nederby; Hergens, Maria Pia; Krishnamoorthy, Sriram; Ugarte-Gil, César; Kirwan, Daniela E.; Honeyborne, Isobella; McHugh, Timothy D.; Köser, Claudio U.; Kranzer, Katharina; Tiberi, Simon; Migliori, Giovanni Battista; Mao, Qiang; Yang, Yue; Oliveira, Simoni Pimenta de; Cardoso, Rosilene Fressatti; Detjen, Anne; Marais, Ben J.; Gijsel, David de; Reyn, C. Fordham von; Goscé, Lara; Abubakar, Ibrahim; Maeurer, Markus; Zumla, Alimuddin

doi:10.1016/j.ijid.2019.02.024

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Tuberculosis is regarded as a third-world disease and is prevalent in southeast Asia (44%), Africa (24%) and the western Pacific (18%), while there is lower incidence in the eastern Mediterranean (8%), USA (3%) and Europe (3%) [ 3 ]. According to the WHO, in 2018, approximately 10 million people suffered from TB (58% men, 32% women and 10% children) [ 4 ] and almost 87% of this population were from high–burden countries. First–line treatment in TB chemotherapy consists of isoniazid, ethambutol, pyrazinamide and rifampicin [ 5 ], while second–line treatment consists of aminoglycosides (e.g., streptomycin), polypeptides (e.g., capreomycin), fluoroquinolones (e.g., levofloxacin) and other, less–effective, drugs, such as thioamides (e.g., ethionamide) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Antituberculosis Activity of Selected Commercial Essential Oils and Identification of Active Constituents Using a Biochemometrics Approach and In Silico Modeling

et al. 2022

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Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis which has become prevalent due to the emergence of resistant M. tuberculosis strains. The use of essential oils (EOs) as potential anti-infective agents to treat microbial infections, including TB, offers promise due to their long historical use and low adverse effects. The current study aimed to investigate the in vitro anti-TB activity of 85 commercial EOs, and identify compounds responsible for the activity, using a biochemometrics approach. A microdilution assay was used to determine the antimycobacterial activity of the EOs towards some non-pathogenic Mycobacterium strains. In parallel, an Alamar blue assay was used to investigate antimycobacterial activity towards the pathogenic M. tuberculosis strain. Chemical profiling of the EOs was performed using gas chromatography-mass spectrometry (GC-MS) analysis. Biochemometrics filtered out putative biomarkers using orthogonal projections to latent structures discriminant analysis (OPLS-DA). In silico modeling was performed to identify potential therapeutic targets of the active biomarkers. Broad-spectrum antimycobacterial activity was observed for Cinnamomum zeylanicum (bark) (MICs = 1.00, 0.50, 0.25 and 0.008 mg/mL) and Levisticum officinale (MICs = 0.50, 0.5, 0.5 and 0.004 mg/mL) towards M. smegmatis, M. fortuitum, M. gordonae and M. tuberculosis, respectively. Biochemometrics predicted cinnamaldehyde, thymol and eugenol as putative biomarkers. Molecular docking demonstrated that cinnamaldehyde could serve as a scaffold for developing a novel class of antimicrobial compounds by targeting FtsZ and PknB from M. tuberculosis.

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Section: Introductionmentioning

confidence: 99%

Investigating the Antituberculosis Activity of Selected Commercial Essential Oils and Identification of Active Constituents Using a Biochemometrics Approach and In Silico Modeling

et al. 2022

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“…Tuberculosis (TB) is one of the main causes of death and the leading cause from a single infectious agent worldwide. 1 Millions of people continue to fall sick with TB each year, 2 more than 1.7 billion people (about 25 percent of the world population) are estimated to be infected with M. tuberculosis . In 2017, 10 million individuals became ill with TB and 1.6 million died.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Mycobacterium tuberculosis detection in sputum using DNA extracted by sonication

Bello

Morais

Wolf

et al. 2020

The Brazilian Journal of Infectious Diseases

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Toward a point-of-care diagnostic for specific detection of Mycobacterium tuberculosis from sputum samples

Eloi¹,

Nascimento²,

Córdula³

et al. 2020

Tuberculosis

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World Tuberculosis Day March 24th 2019 Theme: “It’s TIME” — International Journal of Infectious Diseases Tuberculosis Theme Series

Cited by 3 publications

References 18 publications

Investigating the Antituberculosis Activity of Selected Commercial Essential Oils and Identification of Active Constituents Using a Biochemometrics Approach and In Silico Modeling

Investigating the Antituberculosis Activity of Selected Commercial Essential Oils and Identification of Active Constituents Using a Biochemometrics Approach and In Silico Modeling

Improvement of Mycobacterium tuberculosis detection in sputum using DNA extracted by sonication

Toward a point-of-care diagnostic for specific detection of Mycobacterium tuberculosis from sputum samples

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