World Tuberculosis Day 2022: aligning COVID-19 and tuberculosis innovations to save lives and to end tuberculosis

Ntoumi, Francine; Nachega, Jean B.; Aklillu, Eleni; Chakaya, Jeremiah; Felker, Irina; Amanullah, Farhana; Yeboah-Manu, Dorothy; Castro, Kenneth G.; Zumla, Alimuddin

doi:10.1016/s1473-3099(22)00142-6

Cited by 16 publications

(16 citation statements)

References 6 publications

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“…Moreover, since children are usually contacted from sick adults, the underdetection of TB cases in adults, and discontinuation of the contact tracing could also be an explanation. 1 During the pandemic, the State of Amazonas was classified as one of the most fragile States with regard to the capacity to serve the population, especially in critical situations, with high demand shock. 29 In addition, it consistently presented the highest incidence rate of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…2 Community-based screening, contact tracing, and active case finding were discontinued. 1,2 Number of patients initiating treatment declined precipitously, and preventive therapy enrolment and care-seeking initiatives were compromised. [1][2][3] Before the pandemic, Brazil was known to have a decentralized TB care network, which placed it in the world ranking of countries with the highest TB case detection rates.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Number of patients initiating treatment declined precipitously, and preventive therapy enrolment and care-seeking initiatives were compromised. [1][2][3] Before the pandemic, Brazil was known to have a decentralized TB care network, which placed it in the world ranking of countries with the highest TB case detection rates. 4 However, like many other countries, it was affected by COVID-19 in early 2020 (first case reported on 26 February 2020), and had to deal with three waves, being the second one the deadliest, and the Omicron-dominated wave the most transmissible one.…”

Section: Introductionmentioning

confidence: 99%

“…In the last two years, the world’s attention has been focused on the most lethal pandemic seen for over a century. 1 Resources of surveillance programs that had been structured and organized for decades moved to the COVID-19 response. This had an overwhelming effect on global health, and tuberculosis (TB) services have been extremely affected.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of the COVID-19 pandemic on tuberculosis notification in Brazil

Pelissari¹,

Batholomay

Johansen

et al. 2022

Preprint

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Background: The COVID-19 pandemic notably impacted tuberculosis notification and detection in Brazil. We estimated the number of unnotified tuberculosis cases by group population over the first two years (2020 and 2021) of the pandemic. Methods: We extracted tuberculosis case notifications from routine national surveillance records and population from Ministry of Health. We estimated trends for case notification during pre-pandemic period (2015 to 2019), stratified by sex, age group, and State with a mixed-effects model. We calculated the unnotified cases during 2020 and 2021 as the difference between expected, and reported values. Findings: We estimated 11647 (95% uncertain interval [95%UI]: 829,22466) unnotified cases for 2020; and, 6170 (95%UI: -4629,16968) for 2021; amounting 17817 unnotified cases over the two years. Of the estimated expected tuberculosis cases in 2020 and 2021, 11.2% were not notified. Across sex and age, men aged 30-59 years had the highest number of unnotified cases, and men aged 0-14 years had the highest proportion of unnotified cases. Case underreporting was significant for 13 (of the 27 States) in 2020, and for four in 2021. Interpretation: Tuberculosis cases notification decreased substantially during the COVID-19 pandemic in Brazil. Our analysis helped identify the most affected populations to plan strategies to mitigate the effects of the pandemic on tuberculosis control.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of the COVID-19 pandemic on tuberculosis notification in Brazil

Pelissari¹,

Batholomay

Johansen

et al. 2022

Preprint

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Asymmetric Total Synthesis and Structural Revision of DAT₂, an Antigenic Glycolipid from Mycobacterium tuberculosis

Lin,

Kaniraj,

Holzheimer

et al. 2024

Angewandte Chemie

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DAT2 is a member of the diacyl trehalose family (DAT) of antigenic glycolipids located in the mycomembrane of Mycobacterium tuberculosis (Mtb). Recently it was shown that the molecular structure of DAT2 had been incorrectly assigned, but the correct structure remained elusive. Herein, the correct molecular structure of DAT2 and its methyl‐branched acyl substituent mycolipanolic acid is determined. For this, four different stereo‐isomers of mycolipanolic acid were prepared in a stereoselective and unified manner, and incorporated into DAT2. Rigorous comparison of the four isomers to the DAT isolated from Mtb H37Rv by NMR, HPLC, GC and mass spectrometry allowed a structural revision of mycolipanolic acid and DAT2. Activation of the macrophage inducible Ca2+‐dependent lectin receptor (Mincle) with all four isomers shows that the natural stereochemistry of mycolipanolic acid / DAT2 provides the strongest activation, which indicates its high antigenicity and potential application in serodiagnostics and vaccine adjuvants.

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Asymmetric Total Synthesis and Structural Revision of DAT₂, an Antigenic Glycolipid from Mycobacterium tuberculosis

Lin,

Kaniraj,

Holzheimer

et al. 2024

Angew Chem Int Ed

View full text Add to dashboard Cite

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World Tuberculosis Day 2022: aligning COVID-19 and tuberculosis innovations to save lives and to end tuberculosis

Cited by 16 publications

References 6 publications

Impact of the COVID-19 pandemic on tuberculosis notification in Brazil

Impact of the COVID-19 pandemic on tuberculosis notification in Brazil

Asymmetric Total Synthesis and Structural Revision of DAT₂, an Antigenic Glycolipid from Mycobacterium tuberculosis

Asymmetric Total Synthesis and Structural Revision of DAT₂, an Antigenic Glycolipid from Mycobacterium tuberculosis

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World Tuberculosis Day 2022: aligning COVID-19 and tuberculosis innovations to save lives and to end tuberculosis

Cited by 16 publications

References 6 publications

Impact of the COVID-19 pandemic on tuberculosis notification in Brazil

Impact of the COVID-19 pandemic on tuberculosis notification in Brazil

Asymmetric Total Synthesis and Structural Revision of DAT2, an Antigenic Glycolipid from Mycobacterium tuberculosis

Asymmetric Total Synthesis and Structural Revision of DAT2, an Antigenic Glycolipid from Mycobacterium tuberculosis

Contact Info

Product

Resources

About

Asymmetric Total Synthesis and Structural Revision of DAT₂, an Antigenic Glycolipid from Mycobacterium tuberculosis

Asymmetric Total Synthesis and Structural Revision of DAT₂, an Antigenic Glycolipid from Mycobacterium tuberculosis