World TB Day 2022: Revamping and Reshaping Global TB Control Programs by Advancing Lessons learnt from the COVID-19 pandemic

Petersen, Eskild; Al-Abri, Seif; Chakaya, Jeremiah; Goletti, Delia; Parolina, Liubov; Wejse, Christian; Mucheleng’anga, Luchenga Adam; Khalili, Sulien Al; Yeboah-Manu, Dorothy; Chanda‐Kapata, Pascalina; Nasiri, Mohammad Javad; Lungu, Patrick; Maeurer, Markus; Tiberi, Simon; Ntoumi, Francine; Battista-Migliori, Giovanni; Zumla, Alimuddin

doi:10.1016/j.ijid.2022.02.057

Cited by 21 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TB is a major cause of ill-health and mortality in many countries, being responsible of up to 10.5 million deaths each year worldwide 1 . Recent COVID-19 pandemic has severely impacted TB diagnosis and treatment, halting the progress made to control TB 2 .…”

Section: Introductionmentioning

confidence: 99%

Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications

Despuig

Fonseca

Habgood-Coote

et al. 2022

Preprint

View full text Add to dashboard Cite

Tuberculosis (TB) disease causes up to 1.5 million deaths every year and represents an important problem of public health at worldwide level. Here, we quantified the gene expression signatures of granuloma biopsies across human TB pulmonary lesions, and validated the best gene candidates using NanoString technology, profiling 157 samples from 40 TB patients who underwent surgery. We characterised the transcriptional profile of the TB granuloma in comparison to healthy tissue, described an 11-gene signature and measured 7 proteins in plasma associated with it. We demonstrated a gradient of immune-related transcript abundance across the granuloma substructure and evidenced metabolically-active Mycobacterium tuberculosis in the lesions. Patients who converted to sputum negative after two months of starting treatment, showed enriched inflammatory pathways in the lesion several months after, supporting use of sputum culture conversion (SCC) as a prognostic biomarker during clinical management and as a factor to prioritise patients when considering lung surgery.

show abstract

Section: Introductionmentioning

confidence: 99%

Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications

Despuig

Fonseca

Habgood-Coote

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…For almost a decade, TB has remained the leading cause of mortality in infectious diseases [ 1 ]. COVID-19 has occupied recent global concern and funding due to its rapid spread [ 2 ] and has reversed the progress made in controlling TB globally [ 93 ]. All resources (hospital care, physicians, rapid testing devices) have been concentrated on fighting COVID-19.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…All resources (hospital care, physicians, rapid testing devices) have been concentrated on fighting COVID-19. Therefore, this global pandemic has led to a substantial delay in TB treatment access for both outpatients and inpatients and has affected their care, including treatment monitoring and evaluation, which are essential in chronic disease [ 2 , 93 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Telehealth opens up opportunities to improve patient care and monitoring while minimizing the burden of logistics, cost, time consumed, and more importantly, removing geographical barriers [ 103 ]. Previously identified as strategies to end COVID-19, adequate infrastructure, healthcare systems, and funds to rapidly contain the outbreak were critical but primarily infeasible in developing countries [ 93 ]. This strategy should not be implemented only in the context of COVID-19, but also in TB management.…”

Section: Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Semi-Automated Therapeutic Drug Monitoring as a Pillar toward Personalized Medicine for Tuberculosis Management

et al. 2022

View full text Add to dashboard Cite

Standard tuberculosis (TB) management has failed to control the growing number of drug-resistant TB cases worldwide. Therefore, innovative approaches are required to eradicate TB. Model-informed precision dosing and therapeutic drug monitoring (TDM) have become promising tools for adjusting anti-TB drug doses corresponding with individual pharmacokinetic profiles. These are crucial to improving the treatment outcome of the patients, particularly for those with complex comorbidity and a high risk of treatment failure. Despite the actual benefits of TDM at the bedside, conventional TDM encounters several hurdles related to laborious, time-consuming, and costly processes. Herein, we review the current practice of TDM and discuss the main obstacles that impede it from successful clinical implementation. Moreover, we propose a semi-automated TDM approach to further enhance precision medicine for TB management.

show abstract

“…Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis [ 1 ]. It has been estimated that about 40 million people are infected with tuberculosis (TB) in 2022 of which 3.5 million are children [ 2 ]. Between 2016 and 2019, the annual death attributed to childhood TB was approximately 200,000 [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Facilitators and Barriers to Implementation of a Childhood Tuberculosis Control Program in Bangladesh: A Mixed-Methods Study from BRAC Urban DOTS Centres in Dhaka

et al. 2022

View full text Add to dashboard Cite

The case detection rate of childhood tuberculosis in Bangladesh is 4%, far below the World Health Organization predicted rate of 10–15% for a country with a high burden of tuberculosis. A concurrent triangulation mixed-methods study was carried out in eight urban DOTS (Directly Observed Treatment, Short-course) centres to investigate the factors contributing to the diagnosis and treatment of childhood tuberculosis. Front-line health care workers (Shasthya Shebika) (n = 111) were surveyed to understand knowledge, attitude, and practice (KAP) of the diagnosis and treatment of childhood tuberculosis. In-depth interviews were conducted with field workers (n = 32) and mothers of TB cases (n = 4). Stakeholders involved in implementing the tuberculosis program (n = 9) participated in the key informant interviews. Knowledge of Shasthya Shebika was associated with the components addressed during refresher training (p = 0.02). Government stewardship, presence of specific guidelines, knowledge and capacity building of front-line health workers were identified as the key facilitators. Frequent turnover of key managerial positions in the government, stigma, delays in seeking care, lack of diagnostic facilities, and poor engagement of private practitioners were identified as major constraints. It was identified that the government should focus on improving diagnostic capacities, conduct research on childhood tuberculosis, and produce awareness materials.

show abstract

World TB Day 2022: Revamping and Reshaping Global TB Control Programs by Advancing Lessons learnt from the COVID-19 pandemic

Cited by 21 publications

References 20 publications

Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications

Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications

Semi-Automated Therapeutic Drug Monitoring as a Pillar toward Personalized Medicine for Tuberculosis Management

Facilitators and Barriers to Implementation of a Childhood Tuberculosis Control Program in Bangladesh: A Mixed-Methods Study from BRAC Urban DOTS Centres in Dhaka

Contact Info

Product

Resources

About