World Sepsis Day: a global agenda to target a leading cause of morbidity and mortality

Editorial: Sepsis in Neonates and Children

“…Integrative approaches may enhance clinical evaluation at the bedside, and enable the development of artificial intelligencebased sepsis recognition and risk stratification tools with the ultimate view to deliver precision medicine. Forth, currently available observational data indicate that the most substantial outcome improvements in sepsis can be achieved by reliable implementation of systems to systematically screen and treat children with sepsis aiming to enhance reliability of sepsis care across health care systems (3,26). Finally, it is imperative that sepsis campaigns work hand in hand with AMS initiatives to reduce unnecessary exposure to antibiotics in children which do not suffer from bacterial infections (5).…”

The myth of septic complications of acute pneumonia

“…The inviolability of this misconception continues to spread today to COVID-19 pneumonia. The severity of this form of the disease is explained by the development of viral sepsis and viral shock, which are considered as causes only by analogy with the existing concept of AP, without any objective evidence [1][2][3].…”

“…Bacterial sepsis and septic shock have for many years been considered the most severe complications and the main cause of death in patients with acute pneumonia (AP). Over the past couple of years, the number of patients with viral pneumonia has increased dramatically, but the frequency of septic complications, currently of viral etiology, actually remains the same [1][2][3]. The simplicity of determining the septic nature of these complications, which does not require microbiological confirmation, should raise doubts about the validity of such a statement, since the diagnosis sets the direction of therapeutic efforts and determines the final result.…”

Early Resuscitation in Paediatric Sepsis Using Inotropes – A Randomised Controlled Pilot Study in the Emergency Department (RESPOND ED): Study Protocol and Analysis Plan

“…The burden of sepsis on child health extends beyond mortality (4,5) to morbidity and long-term sequelae which may dramatically affect Quality of Life (QoL) after discharge (6,7). Improving recognition and treatment of sepsis is a priority for the World Health Organisation (8), and regional initiatives to improve the treatment of children with sepsis are underway in several countries (9,10). Currently, best practice comprises timely delivery of a bundle consisting of intravenous antibiotics, blood culture and lactate sampling, and intravenous fluid boluses (11).…”