World Heart Federation Roadmap on Atrial Fibrillation – A 2020 Update

Freedman, Ben; Hindricks, Gerhard; Banerjee, Amitava; Baranchuk, Adrián; Ching, Chi Keong; Du, Xin; Fitzsimons, Donna; Healey, Jeff S.; Ikeda, Takanori; Lobban, Trudie; Mbakwem, Amam; Narasimhan, Calambur; Neubeck, Lis; Noseworthy, Peter A.; Philbin, Daniel M.; Pinto, Fausto J.; Rwebembera, Joselyn; Schnabel, Renate B.; Svendsen, Jesper Hastrup; Aguinaga, Luis; Arbelo, Elena; Böhm, Michael; Farhan, Hasan Ali; Hobbs, F D Richard; Martínez‐Rubio, Antoni; Militello, Claudio; Naik, Nitish; Noubiap, Jean Jacques; Perel, Pablo; Piñeiro, Daniel; Ribeiro, Antônio Luiz Pinho; Stępińska, Janina

doi:10.5334/gh.1023

Cited by 43 publications

(23 citation statements)

References 251 publications

(335 reference statements)

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“…Atrial fibrillation is the most common arrhythmia, affecting almost 2% of the general population, and it is a leading cause of stroke, death, and health care burden [ 70 ]. Despite identification of important risk factors for AF, such as old age, arterial hypertension, HF, CAD, valvular heart disease, surgery, and hyperthyroidism, a significant fraction of its risk remains currently unexplained [ 71 ]. Recent studies showed that low vitamin D levels are associated with AF and may be implicated in its pathogenesis, thus suggesting the potential of vitamin D to also become a therapeutic target in this clinical setting [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ].…”

Section: Vitamin D and Atrial Fibrillationmentioning

confidence: 99%

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

et al. 2021

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Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population, observed across all ethnicities and among all age groups. Besides the established role of vitamin D in calcium homeostasis, its deficiency is emerging as a new risk factor for cardiovascular disease (CVD). In particular, several epidemiological and clinical studies have reported a close association between low vitamin D levels and major CVDs, such as coronary artery disease, heart failure, and atrial fibrillation. Moreover, in all these clinical settings, vitamin deficiency seems to predispose to increased morbidity, mortality, and recurrent cardiovascular events. Despite this growing evidence, interventional trials with supplementation of vitamin D in patients at risk of or with established CVD are still controversial. In this review, we aimed to summarize the currently available evidence supporting the link between vitamin D deficiency and major CVDs in terms of its prevalence, clinical relevance, prognostic impact, and potential therapeutic implications.

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Section: Vitamin D and Atrial Fibrillationmentioning

confidence: 99%

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

et al. 2021

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“…Stroke etiology in younger people is less due to the traditional risk factors and improvements in control of these may thus have a greater impact in the older age groups. An important risk factor for ischemic stroke where treatment has improved immensely over the last decade is atrial fibrillation, which increases in prevalence with age ( 13 , 14 ). In our cohort, atrial fibrillation was approximately three times as common in 42–54-year-olds compared to 18–29-year-olds.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Ischemic Stroke Within the Younger Age Group: A Register-Based Study

2022

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BackgroundStroke incidence is decreasing in most developing countries. However, worrisome trends of an increase in the younger population have been described.AimTo investigate sex differences and longitudinal changes in ischemic stroke regarding incidence, cardiovascular risk factors, and outcome, in the young.MethodsThis is an observational study based on the data from the Swedish national stroke registry, Riksstroke. Patients, 18–54 years of age, having ischemic stroke between 2005 and 2018 were included, resulting in a study population of 16,210 patients.ResultsThe incidence was higher in men than in women (30.6 vs. 19.1 per 100,000, P < 0.001). After an initial increase, the incidence stabilized and then decreased, resulting in a similar level in 2018 as in 2005. Atrial fibrillation, diabetes, and usage of anti-hypertensives at stroke onset were more common among men and did not change over time. Smoking was common and slightly more so in women, but with a reduced prevalence in both men and women during the study period. Dependency in Activities of Daily Living (ADL) and case fatality showed no clear trends or sex differences.ConclusionsThe results show that there are sex differences in ischemic stroke in the younger age group regarding incidence and vascular risk factors, particularly smoking. Temporal trends in stroke incidence are difficult to interpret as fluctuations are substantial, largely due to stroke being quite uncommon in the younger population.

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“… 2 AF is one of the most common cardiac arrhythmias and has become a global health interest as its prevalence and associated mortality have grown exponentially in the past decade. 3 Strokes are common in patients with AF; AF also increases the risk of a systemic embolism. 4 AF is a powerful risk factor for strokes, independently increasing the risk by approximately 5 times in all ages.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and All-Cause Mortality in Ischemic Stroke Patients with Atrial Fibrillation: An Analysis from the MIMIC-IV Database

Qin¹,

Liao²,

Lü³

et al. 2022

NDT

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Aim To investigate the association between the hemoglobin-to-red cell distribution width (RDW) ratio (HRR) and all-cause mortality in ischemic stroke patients with atrial fibrillation (AF). Design This study was a retrospective cohort analysis. In total, 1018 ischemic stroke patients with AF were enrolled using the Medical Information Mart for Intensive Care database, (MIMIC)-IV. The patients were divided into four groups according to the HRR values. The primary outcome was 180-day all-cause mortality. Methods Multivariate Cox proportional risk regression models were used to examine the association between HRR and all-cause mortality. The non-linear relationship between HRR and all-cause mortality was confirmed using a Cox proportional risk regression model fitted by cubic spline function and smooth curve fitting. Results A total of 246/1018 patients (24.17%) died. The serum HRR values were negatively associated with 180-day all-cause mortality (hazard ratio (HR) 0.80, 95% confidence interval (CI) 0.68–0.94). A two-piecewise regression model was used to obtain a threshold inflection point value of 9.74. The HR and the 95% CI on the left inflection point were 0.73 and 0.61–0.87 (p = 0.0005); on the right inflection point they were 1.06 and 0.82–1.38 (p = 0.6383). Conclusion The relationship between all-cause mortality and the HRR values was non-linear in ischemic stroke patients with AF. All-cause mortality and HRR values were negatively correlated when the HRR value was ≤9.74.

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World Heart Federation Roadmap on Atrial Fibrillation – A 2020 Update

Cited by 43 publications

References 251 publications

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Sex Differences in Ischemic Stroke Within the Younger Age Group: A Register-Based Study

Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and All-Cause Mortality in Ischemic Stroke Patients with Atrial Fibrillation: An Analysis from the MIMIC-IV Database

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