World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism

Abstract

These practice guidelines for the biological treatment of substance use disorders were developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal during the development of these guidelines was to review systematically all available evidence pertaining to the treatment of substance use disorders, and to reach a consensus on a series of practice recommendations that are clinically and scientifically meaningful based on the available evidence. These guidelines are intended for use by physicians evaluating and treating people with substance use disorders and are primarily concerned with the biological treatment of adults suffering from substance use disorders. The data used to develop these guidelines were extracted primarily from various national treatment guidelines for substance use disorders, as well as from meta-analyses, reviews and randomized clinical trials on the efficacy of pharmacological and other biological treatment interventions identified by a search of the MEDLINE database and Cochrane Library. The identified literature was evaluated with respect to the strength of evidence for its efficacy and then categorized into four levels of evidence (A-D). This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence.

Successful Treatment of Chronic Resistant Alcoholism by Deep Brain Stimulation of Nucleus Accumbens: First Experience with Three Cases

“…Currently, following successful detoxifi cation, a combination of pharmacotherapy, psychotherapy and other psychosocial interventions is recommended as standard treatment of alcohol dependence to achieve abstinence [11] . Although these interventions have shown to be signifi cantly eff ective when compared to placebo or non-treatment, the majority of the addicted do not achieve abstinence and subsequently develop physical and / or psychological complications.…”

Alcohol withdrawal delirium - diagnosis, course and treatment

“…In symptomatic therapy, benzodiazepines are the drugs of choice; in some regions, clomethiazole is used as well [72][73][74][75][76][77][78] . In alcohol withdrawal delirium, supportive therapy is essential as well.…”

“…In mild or moderate symptoms of alcohol withdrawal, carbamazepine may be used as an alternative drug but its use in withdrawal delirium has not been sufficiently proved 75 . Under certain conditions, other additional drugs may be used together with benzodiazepines, for example antipsychotics (haloperidol, beta-blockers, clonidine or phenytoin) (ref.…”

Alkol Aşermesi, Glutamat ve Akamprosat / Alcohol Craving, Glutamate and Acamprosate

“…Alkol bağımlılığında depreşmenin önlenmesi, birincil hedefin uzun dönemli ya da yaşam boyu ayıklık olduğu psikosoyal veya farmakolojik tedaviye veya her ikisine birden dayanır (68). Psikososyal girişimler tek başına bir tedavi biçimi olarak önerilse de, WFSBP (World Federation of Societies of Biological Psychiatry) (68) gibi güncel tedavi kılavuzları, aşerme giderici ilaçlar gibi farmakolojik tedavilerin sadece profesyonel psikososyal destek ya da psikososyal terapi varlığında öneril-mesini tavsiye etmektedir (69).…”