Background: Performances in the 110-metre hurdles sprint differ for Elite Hurdles Specialists (EHS) and Elite Decathletes (ED), possibly resulting in technical differences. This study aims to compare the kinematics of hurdle clearance and the first stride inter-hurdles of EHS and ED. Methods: This is a cross-sectional study involving twenty male athletes volunteered for the investigation (10 male EHS, and 10 male ED). Each athlete had previously achieved a 110m hurdles in a real competitive practice situation, and the kinematic parameters were determined by using kinematic analysis. The indices of spatial and temporal interaction in the support phase, as well as the angular parameters of motion and height of the body center of mass (CM) for various postures, were determined. Results: EHS were characterized by faster hurdle crossing (p < 0.01), shorter stride length over the hurdle (p < 0.05), and a shorter support phase in the first stride post-hurdle (p < 0.01). The CM path of ED was higher than that of EHS (p < 0.01). EHS attack the hurdle with the lead leg knee significantly more flexed (p < 0.001) and after crossing the hurdle, regain contact with the ground with the lead leg more flexed at the hip level (p < 0.01), the trunk more inclined forward (p < 0.01), and a relatively smaller positioning angle of the supporting leg (p < 0.05). Conclusions: EHS were distinguished by maintaining efficient sprinting mechanics over the hurdles, enabling them to develop optimal velocity between hurdles. This was reflected in both a shorter impulse time and a considerable reduction of braking forces at the touchdown. In addition, EHS showed a more fluid and quicker resumption of optimal speed between hurdles, resulting in minimal loss of speed and superior performance.