Workplace monitoring of PBDFs and PBDDs during extrusion production and injection molding of a poly-butyleneterephthalate (PBTP)/glass fiber/tetrabromo-bisphenol A carbonate oligome ; part II

Brenner, K.S.; Knies, H.

doi:10.1016/0045-6535(93)90022-w

Cited by 4 publications

(2 citation statements)

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“…Workplace air concentrations of tetra-BDDs and tetra-BDFs measured during the extruder production and injection molding of polybutyleneterephthalate polymer blended with the glass fiber, Sb 2 O 3 and decabromodiphenylether (DBDPE) were reported to be 2 and 34 ng/m 3 , respectively (5). The same manufacturing process using tetrabromobisphenol was reported to contaminate workplace air with total PBDDs/PBDFs ranging from 30 to 260 pg/m 3 (6). The concentration of 2,3,7,8-tetrabromodibenzop-dioxin (TBDD) in human adipose tissue collected from the general Japanese population was reported to have a median value of 1.7 pg/g with a range of 0.8-4.2 pg/g in 1970 and a median value of 0.5 pg/g with a range of 0.1-2.0 pg/g in 2000 (8).…”

Section: Introductionmentioning

confidence: 99%

“…Polybromodibenzo-p-dioxins (PBDDs) and polybromodibenzofurans (PBDFs) are not intentionally produced, but are formed during the thermal decomposition processes of plastics, carpets, textiles and other materials containing brominated flame retardants in incinerators and fires (1)(2)(3)(4) and during the extrusion and molding processes of polybrominated biphenyl and diphenylether flame retardants in workplaces (1,5,6). Waste residues from various products of brominated flame retardants incinerated in a laboratory-scale incinerator were reported to contain total PBDDs/PBDFs ranging between 3000 and 130,000 ng/g (4).…”

Section: Introductionmentioning

confidence: 99%

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Systemic and myelotoxic effects of single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats

Yamamoto

Nagano

Senoh

et al. 2006

Environ. Health Prev. Med.

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Objective: Systemic and myelotoxic effects of 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) were examined by the single administration of TBDD by gavage to rats.Methods: Fifteen Wistar rats of both sexes per group received 0, 10, 30, 100 or 300 μg TBDD/kg body weight. Rats surviving to the scheduled necropsy on Days 2, 7 and 36 after TBDD administration were examined for growth rate, organ weight, hematology, histopathology and adipose tissue levels of TBDD.Results: Three 300 μg/kg-dosed females died on Days 21, 23 and 27, and exhibited a marked decrease in body weight, severe thymic atrophy, decreased bone marrow hematopoiesis and hemorrhage in the subarachnoid space of brain and spinal cord. TBDD-dosed surviving rats exhibited growth retardation, decreased bone marrow hematopoiesis, decreases in red blood cell counts, hemoglobin concentrations, and hematocrit values, an increase in reticulocytes and decreases in platelet counts, white blood cell counts and eosinophils. These signs suggested TBDD myelotoxicity. Splenic extramedullary hematopoiesis was increased in both sexes given TBDD, whereas atrophy of the splenic white pulp occurred only in TBDD-dosed females. Marked decreases in body weights and the size and weight of the thymus, severe thymic atrophy and death in TBDD-dosed females suggested a wasting syndrome. The adipose tissue level of TBDD culminated on Day 7 and decreased to 20-30% of the Day 7 level on Day 36.Conclusions: The TBDD-induced effects were characterized by a wasting syndrome and myelotoxicity that appeared at the dose levels of 30 μg/kg and higher and caused death in 300 μg/kg-dosed females.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic and myelotoxic effects of single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats

Yamamoto

Nagano

Senoh

et al. 2006

Environ. Health Prev. Med.

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Formation of PBDD/F from flame-retarded plastic materials under thermal stress

Ebert

Bahadir

2003

Environment International

148

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Dose- And Time-Dependent Effects of 2,3,7,8-Tetrabromodibenzo-P-Dioxin on Rat Liver

et al. 2007

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-Dose-and time-dependent effects of 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) on the liver were examined by single administration of TBDD by gavage to male and female rats. Fifteen Wistar rats of each sex per group received 0, 10, 30, 100 or 300 μg TBDD/kg body weight. Rats surviving to scheduled necropsy on Day 2, 7 or 36 after the TBDD administration were examined for hepatic histopathology, activities of hepatic microsomal enzymes and serum levels of lipids, total cholesterol and transaminases and hepatic concentrations of TBDD. Tigroid basophilic cytoplasm and hepatocellular hypertrophy were observed at 10 μg/kg on Day 2 or 7 through 36, whereas degenerative and aggressive lesions such as necrosis, fibrosis, multinucleated hepatocytes and disarrangement of hepatocytes occurred later at higher dose levels. Persistently increased activities of hepatic aryl hydrocarbon hydroxylase (AHH), ethoxycoumarin O-deethylase (ECOD) and ethoxyresorufin O-deethylase (EROD), increased serum levels of total cholesterol and phospholipid and increased relative liver weight were observed in all groups dosed 10 μg/kg and above, suggesting that hepatic microsomal monooxygenases and basophilic cytoplasm of hepatocytes were early and sensitive indicators among those TBDD-induced effects. A dosedependent increase in liver concentrations of TBDD on Day 2 was followed by logarithmic decreases in TBDD concentrations against the days elapsed after the TBDD administration. An elimination half-life (t 1/2 ) of TBDD from the liver was estimated to range from 12 to 16 days. It was suggested that females were more susceptible to TBDD than males, and that acute hepatotoxicity of TBDD was as potent as that of 2,3,7,.

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Workplace monitoring of PBDFs and PBDDs during extrusion production and injection molding of a poly-butyleneterephthalate (PBTP)/glass fiber/tetrabromo-bisphenol A carbonate oligome ; part II

Cited by 4 publications

References 1 publication

Systemic and myelotoxic effects of single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats

Systemic and myelotoxic effects of single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats

Formation of PBDD/F from flame-retarded plastic materials under thermal stress

Dose- And Time-Dependent Effects of 2,3,7,8-Tetrabromodibenzo-P-Dioxin on Rat Liver

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