Working Safely with Experimental Animals Exposed to Biohazards

Swearengen, James R.; Carpenter, Calvin B.

doi:10.1016/b978-0-12-409527-4.00027-4

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…When working with biohazards, a common approach is to use an agent‐ and activity‐based risk assessment that involves the following components: identification of the hazard; identification of the activities that can result in exposure to a hazard; the likelihood of the hazard to cause harm upon exposure; and determining the possible consequences . (p16) A risk assessment matrix is a common tool used to visualize and quantify the overall risk and is based on 2 criteria: the likelihood or the probability of the event occurring; and the consequences or the severity of the impact if the risk occurs . (p1297) When working with animals, it is critical that the additional risks the animals and related experimental activities create are factored into the risk assessment equation.…”

Section: Programmatic Considerationsmentioning

confidence: 99%

“…When standard laboratory practices are not sufficient to control the hazards associated with a particular agent or laboratory procedure, additional measures may be needed. In those cases, safety practices and techniques must be supplemented by appropriate facility design and engineering features, safety equipment, personal protective equipment, and management practices . (p1319)…”

Section: Programmatic Considerationsmentioning

confidence: 99%

“…Maintenance of those conditions involves activities such as changing cages and bedding, as well as routine sanitation of animal caging, racks, and the secondary environment. Cleaning and disinfection are important aspects of any sanitation program and the difference between the 2 methods should be understood in a biocontainment environment . (p1305) Cleaning is the removal of excessive amounts of gross contamination caused by animal waste, dirt, and debris, while disinfection is the reduction or elimination of unacceptable concentrations of microorganisms .…”

Section: Procedural Considerationsmentioning

confidence: 99%

See 2 more Smart Citations

Safety considerations for working with animal models involving human health hazards

Carpenter

2018

Anim Models and Exp Med

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A human health hazard may constitute a variety of hazards that are encountered in an animal facility. Health hazards include physical, chemical, radioactive, or biological hazards such as cage and rack washers, chemicals used for cleaning and disinfection, experimental drugs or biologics, radioactive isotopes, zoonotic diseases, allergens, experimental infectious agents, or biological toxins. This article will focus on experimental infectious agents and biological toxins (biohazards) that are hazardous to both animals and humans and require biological containment (biocontainment) to prevent their inadvertent release into the environment. Key areas for safely managing a biocontainment animal care and use program and vivarium are described. While scientific research involving health hazards has created some challenges, it has also provided some excellent advances in methods and technologies. The ideas and approaches in this article will be useful for those just entering this field of research and those who have committed their careers to the safe use of animals exposed to biohazards.

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Section: Programmatic Considerationsmentioning

confidence: 99%

Section: Programmatic Considerationsmentioning

confidence: 99%

Section: Procedural Considerationsmentioning

confidence: 99%

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Safety considerations for working with animal models involving human health hazards

Carpenter

2018

Anim Models and Exp Med

Self Cite

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Biosafety Consideration in Laboratory Animal Facilities and Working on Infectious Agents

Parthiban

Azhahianambi

Karthik

et al. 2021

Essentials of Laboratory Animal Science: Principles and Practices

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Common Challenges in Safety: A Review and Analysis of AAALAC Findings

Swearengen¹

2018

ILAR Journal

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The 8th edition of the Guide for the Care and Use of Laboratory Animals (Guide) is clear in its requirement for each institution to establish and maintain an occupational health and safety (OHS) program as an essential part of the overall program of animal care and use. For over 30 years, AAALAC International has utilized a variety of methods to evaluate this component of OHS programs as part of the accreditation process. AAALAC International began collecting data on site visit findings over 20 years ago using the Guide as a template for establishing the categories and subcategories to which findings are assigned. Data from 1656 findings associated with OHS were identified during calendar years 2014 through 2016. This information was used to provide an overview of the most frequently observed OHS findings that occurred during this time span. The 5 categories representing key OHS areas and the combined percentage of both mandatory findings and suggestions for improvement in each category included: workplace risk/safety assessment (37.3%); personnel protection (36.3%); personnel risk assessment (14.4%); hazard containment (9.4%); and medical services (2.6%). Information on the most commonly observed OHS findings and associated trends may be helpful to animal care and use programs when conducting internal reviews of their own OHS programs.

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Working Safely with Experimental Animals Exposed to Biohazards

Cited by 3 publications

References 15 publications

Safety considerations for working with animal models involving human health hazards

Safety considerations for working with animal models involving human health hazards

Biosafety Consideration in Laboratory Animal Facilities and Working on Infectious Agents

Common Challenges in Safety: A Review and Analysis of AAALAC Findings

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