Working memory of school-aged children with a history of febrile convulsions

Chang, Ying; Guo, Nai-Wen; Wang, S. T.; Huang, Chao; Tsai, Jason Sheng Hong

doi:10.1212/wnl.57.1.37

Cited by 88 publications

(72 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19 Reducing fever to prevent febrile convulsions is ineffective and unwarranted as they are benign events in five per cent of children aged three months to five years. 20 The current World Health Organization (WHO) guidelines on the management of fever recommend the use of paracetamol for treating children with a temperature over 38.5°C which indicates that mild to moderate rise, should not be routinely suppressed. 21 Parental knowledge about normal temperature and the temperature that means fever is weak.…”

Section: Introductionmentioning

confidence: 99%

Kuwaiti parent's knowledge of their childern's fever and their patterns of use of over the counter antipyretics

Badawy¹,

Alhajraf²,

Alsamdan³

2017

AMJ

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Kuwaiti parent's knowledge of their childern's fever and their patterns of use of over the counter antipyretics

Badawy¹,

Alhajraf²,

Alsamdan³

2017

AMJ

View full text Add to dashboard Cite

“…In another population-based study that examined the effects of FS on working memory, Chang et al revealed that 87 school-aged children with FS performed significantly better than 87 age-matched control children in learning, consolidation, memory retrieval, and delayed recognition (93); however, it should be noted that those children with an onset of FS before 1 year of age had deficits in these properties, suggesting an age-dependent vulnerability to FS.…”

Section: Do Fs Affect the Behavior In Later Life?mentioning

confidence: 99%

Novel Etiological and Therapeutic Strategies for Neurodiseases: Mechanisms and Consequences of Febrile Seizures: Lessons From Animal Models

Koyama

Matsuki

2010

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. Febrile seizures (FS) are the most common type of convulsive events in infancy and childhood. Genetic and environmental elements have been suggested to contribute to FS. FS can be divided into simple and complex types, the former being benign, whereas it is controversial whether complex FS have an association with the development of temporal lobe epilepsy (TLE) in later life. In the hippocampus of TLE patients, several structural and functional alterations take place that render the region an epileptic foci. Thus, it is important to clarify the cellular and molecular changes in the hippocampus after FS and to determine whether they are epileptogenic. To achieve this goal, human studies are too limited because the sample tissues are only available from adult patients in the advanced and drug-resistant stages of the disease, masking the underlying etiology. These facts have inspired researchers to take advantage of well-established animal models of FS to answer the following questions: 1) How does hyperthermia induce FS? 2) Do FS induce neuroanatomical changes? 3) Do FS induce neurophysiological changes? 4) Do FS affect the behavior in later life? Here we introduce and discuss accumulating reports to answer these questions.

show abstract

“…20 Because simple febrile seizures have not been associated with hippocampal injury in either human or animal data, future research should focus on memory and other hippocampal-dependent functions in children who experience prolonged febrile seizures. Chang et al 1 demonstrate the feasibility of such studies. We now need large-scale investigations analyzing the contribution of seizure duration and the age of the child at seizure onset to specific outcome measures of learning and memory.…”

mentioning

confidence: 97%

“…These effects may be age dependent, and more pronounced during the first postnatal year. The strength of the study by Chang et al 1 is its focus on well-defined, sophisticated measures of hippocampal-dependent working memory function, allowing relatively subtle deficits to be detected.…”

mentioning

confidence: 99%

“…Some studies have found adverse outcomes on intelligence in children with prolonged febrile seizures, 19 though others have not. [14][15][16] Because Chang et al 1 had 87 children with febrile seizures, the number with prolonged febrile seizures was relatively small. Approximately 10% of all febrile seizures last more than 15 minutes, and 5% last 30 minutes or longer.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Do febrile seizures improve memory?

Baram¹,

Shinnar²

2001

Neurology

View full text Add to dashboard Cite

In this issue of Neurology, Chang et al. 1 present a population-based study on the effects of febrile seizures on working memory, and find that school-aged children with febrile seizures performed significantly better than randomly selected, population-based control subjects. However, children with the onset of febrile seizures before the age of 1 year had deficits in learning, consolidation, and delayed recognition.This article extends prior work on this cohort, 2 which found that these school-aged children, except for those with seizure onset under 1 year of age, performed better than populationbased control subjects on measures of intelligence and academic achievement. The new results published in the current article are of particular interest because they focus specifically on learning and memory aspects, which require an intact hippocampus. In both humans 3,4 and immature animal models, 5,6 prolonged febrile seizures have been associated with acute hippocampal injury. Furthermore, a history of prolonged febrile seizures is commonly elicited in individuals with a specific pattern of chronic hippocampal injury, mesial temporal sclerosis, 3,4,7-9 and mesial temporal lobe epilepsy, which are often associated with impaired memory functions. [10][11][12][13] Prior epidemiologic studies of the outcome of febrile seizures in both United States 14 and the United Kingdom 15,16 also have not found differences in global cognitive outcomes between children with febrile seizures and either siblings 14 or population controls, 15,16 but these studies did not specifically examine memory. Interestingly, seizure onset before 1 year of age was also a risk factor for poor outcome in the recent British study. 16 The current study adds reassuring data that memory tasks, which are a more specific indicator of hippocampal function, are preserved in the majority if children with febrile seizures, but raises concern regarding those children who experience these seizures during the first postnatal year.Why be concerned specifically about memory and related hippocampal functions in children with febrile seizures, and what factors might underlie the deficits noted specifically in individuals experiencing the seizures during infancy? Both human 3 and animal 5,6,17 data have suggested recently that at least transient injury to hippocampus and related limbic structures can occur in individuals with prolonged febrile seizures. In human studies, prospective data using neuroimaging methods demonstrated acute swelling of hippocampus after prolonged febrile seizures. 3 In an infant rat model of prolonged (20-minute) febrile seizures, cytoskeletal changes in neurons were evident within 24 hours and persisted for several weeks, without leading to cell loss. 5 However, persistently altered functional

show abstract

Working memory of school-aged children with a history of febrile convulsions

Cited by 88 publications

References 29 publications

Kuwaiti parent's knowledge of their childern's fever and their patterns of use of over the counter antipyretics

Kuwaiti parent's knowledge of their childern's fever and their patterns of use of over the counter antipyretics

Novel Etiological and Therapeutic Strategies for Neurodiseases: Mechanisms and Consequences of Febrile Seizures: Lessons From Animal Models

Do febrile seizures improve memory?

Contact Info

Product

Resources

About