Working memory in survivors of childhood acute lymphocytic Leukemia: Functional neuroimaging analyses

Robinson, Kristen E.; Livesay, Katherine L.; Campbell, Laura K.; Scaduto, Mary; Cannistraci, Christopher J.; Anderson, Adam W.; Whitlock, James A.; Compas, Bruce E.

doi:10.1002/pbc.22362

Cited by 69 publications

(79 citation statements)

References 24 publications

(25 reference statements)

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“…(Von der Weid,2001; Langer et al,2002; Hill et al,2004; Spiegler et al,2006; Mahone et al,2007; Aukema et al,2009; Kadan-Lottick et al,2009; Kadan-Lottick et al,2010; Robinson et al,2010; Daams et al,2012; Krawczuk-Rybak et al,2012; Edelmann et al,2013; Genschaft et al,2013; Krull et al,2013; Lewis et al,2013; Ross et al,2013; Schuitema et al,2013; Edelmann et al,2014; Elalfy et al,2014) There were only 4 longitudinal studies that evaluated survivors’ neurocognitive changes from active treatment to post-treatment survivorship phase. (Kingma et al,2001; Harila et al,2009; Halsey et al,2011; Lewis et al,2013) Most studies focused on a pure sample of survivors who received chemotherapy-only treatment protocols while others included separate populations of ALL survivors who received CRT(Kingma et al,2001; Von der Weid,2001; Langer et al,2002; Spiegler et al,2006; Harila et al,2009; Kadan-Lottick et al,2010; Halsey et al,2011; Krull et al,2011; Daams et al,2012; Krull et al,2013; Schuitema et al,2013; Edelmann et al,2014) or patients of other cancer types.…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies included a population of non-cancer controls or a normative healthy sample for comparative purposes. (Kingma et al,2001; Hill et al,2004; Spiegler et al,2006; Mahone et al,2007; Aukema et al,2009; Harila et al,2009; Kadan-Lottick et al,2010; Robinson et al,2010; Halsey et al,2011; Daams et al,2012; Lewis et al,2012; Edelmann et al,2013; Genschaft et al,2013; Krull et al,2013; Lewis et al,2013; Schuitema et al,2013; Edelmann et al,2014; Elalfy et al,2014) All patients in the included studies received customized chemotherapy-only contemporary protocols (referred to as “contemporary protocols” thereafter) that originated from the Berlin-Frankfurt-Münster (BFM) Study Group, Children’s Oncology Group (COG), Dana-Farber Cancer Institute ALL Consortium, Dutch Childhood Leukemia Study Group (DCLSG) and St. Jude Children's Research Hospital (SJCRH). The most commonly administered drugs were vincristine, corticosteroid (hydrocortisone, dexamethasone or prednisone), L-asparaginase, and anthracycline (either doxorubicin or daunorubicin).…”

Section: Resultsmentioning

confidence: 99%

“…(Kingma et al,2001; Von der Weid,2001; Langer et al,2002; Hill et al,2004; Spiegler et al,2006; Mahone et al,2007; Aukema et al,2009; Harila et al,2009; Kadan-Lottick et al,2009; Kadan-Lottick et al,2010; Robinson et al,2010; Halsey et al,2011; Daams et al,2012; Krawczuk-Rybak et al,2012; Lewis et al,2012; Edelmann et al,2013; Genschaft et al,2013; Krull et al,2013; Lewis et al,2013; Ross et al,2013; Schuitema et al,2013; Edelmann et al,2014; Elalfy et al,2014) Commonly utilized neurocognitive batteries were the Amsterdam Neuropsychological Test(De Sonneville,1999), an adult or child version of the Wechsler Intelligence Scale(Wechsler,1997), Delis–Kaplan Executive Function System(Delis et al,2001) and Woodcock Johnson Tests of Achievement(Woodcock et al,2001). …”

Section: Resultsmentioning

confidence: 99%

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Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review

Cheung

Krull

2015

Neuroscience & Biobehavioral Reviews

143

145

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The intensified administration of chemotherapeutic drugs has gradually replaced cranial radiation therapy (CRT) for the treatment of childhood acute lymphoblastic leukemia (ALL). While CRT is often implicated in neurocognitive impairment in ALL survivors, there is a paucity of literature that evaluates the persistence of neurocognitive deficits in long-term survivors of pediatric ALL who were treated with contemporary chemotherapy-only protocols. Results from this systematic review concurred to the probable cognitive-sparing effect of chemotherapy-based protocols over CRT in long-term survivors. However, coupled with multiple intrinsic and extrinsic factors, survivors who received chemotherapy treatment still suffered from apparent cognitive impairment, particularly in the attention and executive function domains. Notably, there is evidence to suggest that the late neurotoxic effect of methotrexate on survivors’ neurocognitive performance may be dose-related. This review also recommends future pharmacokinetic, neuroimaging and genetic studies to illuminate the multifactorial nature of this subject matter and discusses the potential value of neurochemical, physiological, inflammatory and genetic markers for the prediction of susceptibility to neurocognitive impairment in long-term survivors of childhood ALL.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review

Cheung

Krull

2015

Neuroscience & Biobehavioral Reviews

143

145

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“…Differential activation in these regions has been observed between healthy controls and mild traumatic brain injury (Chen et al, 2012; McAllister et al, 1999), multiple sclerosis (Sweet, Rao, Primeau, Durgerian, & Cohen, 2006), and survivors of childhood ALL (Robinson et al, 2010). Moreover, prefrontal regions activated by N-back performance are among the last to myelinate and demonstrate increased activation with age (Ciesielski, Lesnik, Savoy, Grant, & Ahlfors, 2006; Klingberg, Forssberg, & Westerberg, 2002; Thomason et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Utility of the N-back task in survivors of childhood acute lymphoblastic leukemia

Luxton

Brinkman

Kimberg

et al. 2014

Journal of Clinical and Experimental Neuropsychology

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The N-back task is often used in functional brain imaging studies to activate working memory networks; however, limited information is available on its association to clinical outcomes in children or cancer survivors. One hundred thirty-seven survivors of ALL (mean [SD] current age = 14.3 [4.8] years; time since diagnosis = 7.6 [1.6] years) completed the N-back task and comprehensive neurocognitive testing, including standardized measures of attention, processing speed, and working memory. Results indicated females demonstrated significantly slower reaction times (0-back p=0.02; 1-back p=0.03) compared to males. Survivors < 15 years old at the time of testing demonstrated a significant decrease in accuracy as working memory load increased compared to survivors ≥ 15 years old (p<0.001). Performance on the N-back task was associated with nonverbal working memory (rs=0.56, p<0.001) in survivors ≥ 15 years of age. For younger survivors, N-Back performance was more strongly associated with attention skills. Results suggest the N-back assesses different cognitive constructs at younger compared to older childhood ages. These age differences should be considered in interpreting functional brain imaging results.

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“…Treatment for tumors located in the cerebral hemispheres have been found to be associated with poor IQ, memory, attention, and motor skills (Armstrong et al, 2010; Ater et al, 1996; Robinson et al, 2010). Cranial radiation is associated with brain white matter reduction, particularly in survivors diagnosed at young ages (Armstrong et al, 2013; Mulhern et al, 2004; Palmer et al, 2003).…”

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confidence: 99%

The Childhood Cancer Survivor Study–Neurocognitive Questionnaire (CCSS-NCQ) Revised: Item response analysis and concurrent validity.

Kenzik

Huang²,

Brinkman³

et al. 2015

Neuropsychology

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Objective Childhood cancer survivors are at risk for neurocognitive impairment related to cancer diagnosis or treatment. This study refined and further validated the Childhood Cancer Survivor Study Neurocognitive Questionnaire (CCSS-NCQ), a scale developed to screen for impairment in long-term survivors of childhood cancer. Method Items related to task efficiency, memory, organization and emotional regulation domains were examined using item response theory (IRT). Data were collected from 833 adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study who completed self-report and direct neurocognitive testing. The revision process included: 1) content validity mapping of items to domains, 2) constructing a revised CCSS-NCQ, 3) selecting items within specific domains using IRT, and 4) evaluating concordance between the revised CCSS-NCQ and direct neurocognitive assessment. Results Using content and measurement properties, 32 items were retained (8 items in 4 domains). Items captured low to middle levels of neurocognitive concerns. The latent domain scores demonstrated poor convergent/divergent validity with the direct assessments. Adjusted effect sizes (Cohen's d) for agreement between self-reported memory and direct memory assessment were moderate for total recall (ES=0.66), long-term memory (ES=0.63), and short-term memory (ES=0.55). Effect sizes between self-rated task efficiency and direct assessment of attention were moderate for focused attention (ES=0.70) and attention span (ES=0.50), but small for sustained attention (ES=0.36). Cranial radiation therapy and female gender were associated with lower self-reported neurocognitive function. Conclusion The revised CCSS-NCQ demonstrates adequate measurement properties for assessing day-to-day neurocognitive concerns in childhood cancer survivors, and adds useful information to direct assessment.

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Working memory in survivors of childhood acute lymphocytic Leukemia: Functional neuroimaging analyses

Cited by 69 publications

References 24 publications

Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review

Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review

Utility of the N-back task in survivors of childhood acute lymphoblastic leukemia

The Childhood Cancer Survivor Study–Neurocognitive Questionnaire (CCSS-NCQ) Revised: Item response analysis and concurrent validity.

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