2017
DOI: 10.1007/978-3-319-54130-3_17
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Working Memory Function in Recent-Onset Schizophrenia Patients Associated with White Matter Microstructure: Connectometry Approach

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“…Studies have shown a decreased number of OLs in the hippocampus causing a disturbance in the neurocircuitry between the hippocampus and hypothalamus leading to cognitive deficits in patients with schizophrenia (69,70). Furthermore, myelination deficits and dysfunctional synapses observed in the disorder can be correlated to the dysfunction of neuronal and glial function (71)(72)(73), along with cognitive impairment, including deficits in episodic and working memory (74) and in visual processing (75). Moreover, disruptions in OL integrity such as altered morphology and distribution (3), decreased density (76), and altered expression of myelination-related genes and proteins have been reported in patients with schizophrenia (71,77,78).…”
Section: Ols and Myelin Impairment In Schizophreniamentioning
confidence: 99%
“…Studies have shown a decreased number of OLs in the hippocampus causing a disturbance in the neurocircuitry between the hippocampus and hypothalamus leading to cognitive deficits in patients with schizophrenia (69,70). Furthermore, myelination deficits and dysfunctional synapses observed in the disorder can be correlated to the dysfunction of neuronal and glial function (71)(72)(73), along with cognitive impairment, including deficits in episodic and working memory (74) and in visual processing (75). Moreover, disruptions in OL integrity such as altered morphology and distribution (3), decreased density (76), and altered expression of myelination-related genes and proteins have been reported in patients with schizophrenia (71,77,78).…”
Section: Ols and Myelin Impairment In Schizophreniamentioning
confidence: 99%