Working Memory and Verbal Fluency Deficits Following Cerebellar Lesions: Relation to Interindividual Differences in Patient Variables

Peterburs, Jutta; Bellebaum, Christian; Koch, Benno; Schwarz, Michael; Daum, Irene

doi:10.1007/s12311-010-0171-z

Cited by 63 publications

(35 citation statements)

References 47 publications

(65 reference statements)

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“…Despite conflicting results with regard to the laterality and specificity of cerebellar involvement in verbal fluency, clinical and neurophysiological studies have reported that the ability to generate lists of words per the phonemic rule is more affected than under the semantic rule [132, 133, 135, 136, 138, 139], with a specific damage on category switching [138] [132]. …”

Section: Cerebellum and Verbal Fluency (Phonological And Semantic) (Mmentioning

confidence: 99%

Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Mariën

Ackermann

Adamaszek³

et al. 2013

Cerebellum

319

351

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In less than three decades, the concept “cerebellar neurocognition” has evolved from a mere afterthought to an entirely new and multifaceted area of neuroscientific research. A close interplay between three main strands of contemporary neuroscience induced a substantial modification of the traditional view of the cerebellum as a mere coordinator of autonomic and somatic motor functions. Indeed, the wealth of current evidence derived from detailed neuroanatomical investigations, functional neuroimaging studies with healthy subjects and patients and in-depth neuropsychological assessment of patients with cerebellar disorders shows that the cerebellum has a cardinal role to play in affective regulation, cognitive processing, and linguistic function. Although considerable progress has been made in models of cerebellar function, controversy remains regarding the exact role of the “linguistic cerebellum” in a broad variety of nonmotor language processes. This consensus paper brings together a range of different viewpoints and opinions regarding the contribution of the cerebellum to language function. Recent developments and insights in the nonmotor modulatory role of the cerebellum in language and some related disorders will be discussed. The role of the cerebellum in speech and language perception, in motor speech planning including apraxia of speech, in verbal working memory, in phonological and semantic verbal fluency, in syntax processing, in the dynamics of language production, in reading and in writing will be addressed. In addition, the functional topography of the linguistic cerebellum and the contribution of the deep nuclei to linguistic function will be briefly discussed. As such, a framework for debate and discussion will be offered in this consensus paper.

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Section: Cerebellum and Verbal Fluency (Phonological And Semantic) (Mmentioning

confidence: 99%

Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Mariën

Ackermann

Adamaszek³

et al. 2013

Cerebellum

319

351

View full text Add to dashboard Cite

show abstract

“…In the last two decades, many studies have progressively demonstrated the range of cognitive deficits associated with cerebellar dysfunction, including linguistic processing (Klein, Milner, Zatorre, Meyer, & Evans, 1995), verbal fluency (Richter et al, 2005;Peterburs, Bellebaum, Koch, Schwarz, & Daum, 2010), visuospatial functions (Molinari, Petrosini, Misciagna, & Leggio, 2004;Neau, Arroyo-Anllo, Bonnaud, Ingrand, & Gil, 2000), procedural learning (Shin and Ivry, 2003); verbal memory (Grasby et al, 1993), executive functions (Bellebaum and Daum, 2007;Gottwald, Wilde, Mihajlovic, & Mehdorn, 2004), attention (Gottwald, Mihajlovic, Wilde, & Mehdorn, 2003), working memory , sequencing Tedesco et al, 2011), and emotion (Schmahmann & Sherman, 1998;Turner et al, 2007). In a large group of patients with focal cerebellar damage (N ¼ 156), Tedesco et al (2011) found that among the various cognitive domains, the ability to sequence was most severely affected.…”

Section: Introductionmentioning

confidence: 99%

Successful neuropsychological rehabilitation in a patient with Cerebellar Cognitive Affective Syndrome

Ruffieux¹,

Colombo²,

Gentaz

et al. 2016

Applied Neuropsychology: Child

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The objective of this case study was to describe the neuropsychological rehabilitation of a 16-year-old patient who presented a Cerebellar Cognitive Affective Syndrome (CCAS) following a bilateral cerebellar hemorrhage. The patient presented severe and diffuse cognitive deficits, massive behavioral disorders, and emotion regulation difficulties. The cognitive rehabilitation was performed in the chronic phase (one year after the onset of the hemorrhage) using a transdisciplinary neurobehavioral approach based on the patient's favorite interest (soccer). A significant behavioral and cognitive improvement was observed. The patient became progressively independent in all activities of daily living and was discharged home. The Functional Independence Measure at discharge was 124=126 (vs. 37=126 at entry). The patient was able to complete his schooling despite the mild cognitive and behavioral sequelae. This first description of the use of neurobehavioral therapy in a case of chronic CCAS suggests that (a) major clinical improvement can occur more than one year after the onset of the CCAS, showing the importance of long-term and intensive neurorehabilitation; and (b) when the cerebellum cannot properly play its regulator role in cognition, neuropsychological intervention through a behavioral and cognitive approach can be of great help by acting as an external modulator to help the patient regain control over himself.

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“…Cerebellar contribution to working memory in humans has been established based on human cerebellar lesion and functional imaging studies in healthy subjects [1][2][3][4]. According to the model of Baddeley and Hitch [5], working memory has been subdivided into different components.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar fMRI Activation Increases with Increasing Working Memory Demands

et al. 2015

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The aim of the present study was to explore cerebellar contributions to the central executive in n-back working memory tasks using 7-T functional magnetic imaging (fMRI). We hypothesized that cerebellar activation increased with increasing working memory demands. Activations of the cerebellar cortex and dentate nuclei were compared between 0-back (serving as a motor control task), 1-back, and 2-back working memory tasks for both verbal and abstract modalities. A block design was used. Data of 27 participants (mean age 26.6 ± 3.8 years, female/male 12:15) were included in group statistical analysis. We observed that cerebellar cortical activations increased with higher central executive demands in n-back tasks independent of task modality. As confirmed by subtraction analyses, additional bilateral activations following higher executive demands were found primarily in four distinct cerebellar areas: (i) the border region of lobule VI and crus I, (ii) inferior parts of the lateral cerebellum (lobules crus II, VIIb, VIII, IX), (iii) posterior parts of the paravermal cerebellar cortex (lobules VI, crus I, crus II), and (iv) the inferior vermis (lobules VI, VIIb, VIII, IX). Dentate activations were observed for both verbal and abstract modalities. Task-related increases were less robust and detected for the verbal n-back tasks only. These results provide further evidence that the cerebellum participates in an amodal bilateral neuronal network representing the central executive during working memory n-back tasks.

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Working Memory and Verbal Fluency Deficits Following Cerebellar Lesions: Relation to Interindividual Differences in Patient Variables

Cited by 63 publications

References 47 publications

Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Successful neuropsychological rehabilitation in a patient with Cerebellar Cognitive Affective Syndrome

Cerebellar fMRI Activation Increases with Increasing Working Memory Demands

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