Worker environment research: rapid field method for estimation of organophosphorus insecticide residues on citrus foliage and in grove soil

Berck, Ben; Iwata, Yutaka; Günther, F. A.

doi:10.1021/jf00104a001

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…Several applications have also involved the detection of organophosphorous pesticides, 144 estimation of insecticide levels on agricultural crop foliage, 145 and the validation of an oxidative treatment for alkylating agents present in residual waters. 146 NBP has very often been used as a TLC-developing agent, usually to detect organophosphorous pesticides 109,113,115 but also aza-heterocycles, such as diazinon, 147 trichothecene mycotoxins, 112 nitrosoureas, 148 or drugs such as thioTE-PA. 104,111 Addressing the detection of phosgene, a toxic atmospheric pollutant and an industrial chemical, Nakano et al developed a porous tape impregnated with a NBP solution able to detect 6 ppb of phosgene in air.…”

Section: Uses Of the Nbp Methods And Alkylation Mechanismsmentioning

confidence: 99%

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Potential of the NBP Method for the Study of Alkylation Mechanisms: NBP as a DNA-Model

Gómez‐Bombarelli

González‐Pérez

Calle

et al. 2012

Chem. Res. Toxicol.

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Alkylating agents are considered to be archetypal carcinogens. One suitable technique to evaluate the activity of alkylating compounds is the NBP assay. This method is based on the formation of a chromophore in the reaction between the alkylating agent and the nucleophile 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to those of DNA bases. NBP is known to react with strong and weak alkylating agents, and much insight into such alkylation mechanisms in vivo can be gained from kinetic study of some alkylation reactions in vitro. Since 1925, the NBP assay has evolved from being a qualitative, analytical tool to becoming a useful physicochemical method that not only allows the rules of chemical reactivity that govern electrophilicity and nucleophilicity to be applied to the reaction of DNA with alkylating agents but also helps to understand some significant relationships between the structure of many alkylation substrates (including DNA) and their chemical and biological responses. Given that advances in this area have the potential to yield both fundamental and practical advances in chemistry, biology, predictive toxicology, and anticancer drug development, this review is designed to provide an overview of the evolution of the NBP method from its early inception until its recent kinetic–mechanistic approach, which allows the pros and cons of NBP as a DNA-model to be analyzed. The validity of NBP as a nucleophilicity model for DNA in general and the position of guanosine at N7 in particular are discussed.

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Section: Uses Of the Nbp Methods And Alkylation Mechanismsmentioning

confidence: 99%

“…Several applications have also involved the detection of organophosphorous pesticides, estimation of insecticide levels on agricultural crop foliage, and the validation of an oxidative treatment for alkylating agents present in residual waters …”

Section: Uses Of the Nbp Methods And Alkylation Mechanismsmentioning

confidence: 99%

Potential of the NBP Method for the Study of Alkylation Mechanisms: NBP as a DNA-Model

Gómez‐Bombarelli

González‐Pérez

Calle

et al. 2012

Chem. Res. Toxicol.

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A field unit for determining dimethoate in fruit and vegetable dips

1990

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The concentration of dimethoate in post‐harvest dips needs to be maintained at 400 or 500 mg litre−1 to ensure that fruit fly are killed and also to keep residue levels below the MRL. A field unit which contains a colorimeter, a heating block and cooling positions has been evaluated. The diluted dip sample produces a colour with 4‐(p‐nitrobenzyl)pyridine after heating and the addition of tetraethylenepentamine. Precision of the unit was acceptable for a field test (repeatability of ± 10.1%) and there was reasonable agreement between determinations made on the unit and by an HPLC method for a range of dimethoate concentrations from 300 to 700 mg litre−1. The unit can be used at the dip site and the analysis is completed in 30 minutes.

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Production Practices and Quality Assessment of Food Crops

Dris¹,

Jain²

2004

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Worker environment research: rapid field method for estimation of organophosphorus insecticide residues on citrus foliage and in grove soil

Cited by 8 publications

References 9 publications

Potential of the NBP Method for the Study of Alkylation Mechanisms: NBP as a DNA-Model

Potential of the NBP Method for the Study of Alkylation Mechanisms: NBP as a DNA-Model

A field unit for determining dimethoate in fruit and vegetable dips

Production Practices and Quality Assessment of Food Crops

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