Work Stress and Low Sense of Coherence Is Associated With Type 2 Diabetes in Middle-Aged Swedish Women

Agardh, Emilie; Ahlbom, Anders; Andersson, Tomas; Efendić, Suad; Grill, Valdemar; Hallqvist, Johan; Norman, Anders; Östenson, Claes‐Göran

doi:10.2337/diacare.26.3.719

Cited by 150 publications

(145 citation statements)

References 25 publications

(11 reference statements)

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…All individuals were Swedish and selected from the Stockholm Diabetes Prevention Program (SDPP). [11][12][13] They were either (i) healthy control subjects with NGT and BMI p26 kg m À2 (n ¼ 188), or (ii) T2D patients with BMI varying from 18.4 to 45.6 kg m À2 (n ¼ 243) or (iii) obese subjects with NGT and BMI X30 kg m À2 (n ¼ 199). For comprehensive analysis, T2D patients were divided into the subgroups based upon a BMI cutoff of 30 kg m À2 , that is non-obese T2D patients with BMI o30 kg m À2 (n ¼ 151) and obese T2D patients with BMIX30 kg m À2 (n ¼ 92).…”

Section: Subjectsmentioning

confidence: 99%

Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men

et al. 2007

View full text Add to dashboard Cite

Objective: Our previous study using the Goto-Kakizaki rat implicates that the adenylyl cyclase 3 (AC3) is a candidate gene for genetic study of metabolic disorders. The present study aimed to investigate the susceptibility of genetic variation of the AC3 gene in type 2 diabetes (T2D) patients and obese subjects. Subjects and methods: Variation screening in the putative promoter and validation of single nucleotide polymorphisms (SNPs) covering the AC3 gene were performed. In total, 630 Swedish men, including 243 T2D patients (BMI from 18.4 to 45.6 kg m À2 ), 199 obese subjects with normal glucose tolerance (NGT, BMIX30 kg m À2 ) and 188 control subjects (NGT, BMIp26 kg m À2 ), were genotyped. Results: A novel variant -17A/T in the promoter was identified, but no significant association of this polymorphism with T2D was found. SNPs rs2033655 C/T and rs1968482 A/G were found to be significantly associated with obesity when T2D patients had BMIX30 kg m À2 (P ¼ 0.003 and 0.005). The significance was borderline in T2D patients with BMIo30 kg m À2 (P ¼ 0.051 and 0.084) and disappeared in T2D patients with BMIp26 kg m À2 . Importantly, analysis in obese subjects with NGT demonstrated that these two polymorphisms were strongly associated with obesity per se (P ¼ 0.028 and 0.003). Furthermore, analyses for diplotypes (haplotypic genotypes) predicted an association with BMI in obese subjects. Conclusions:The present study provides the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes.

show abstract

Section: Subjectsmentioning

confidence: 99%

Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men

et al. 2007

View full text Add to dashboard Cite

show abstract

“…A summed index was created from the three alternative responses; according to the distribution of responses among all respondents, SOC was categorised as low (low) and high (lower middle, upper middle, high). Low SOC has been shown to be associated with the risk of type 2 diabetes [4].…”

Section: Classification Of Exposurementioning

confidence: 99%

“…The design of this population-based cross-sectional study has been described elsewhere [4,9]. Briefly, it comprised men and women, aged 35-56 years and living in the outskirts of Stockholm.…”

Section: Study Populationmentioning

confidence: 99%

See 1 more Smart Citation

The impact of family history of diabetes and lifestyle factors on abnormal glucose regulation in middle-aged Swedish men and women

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis We investigated associations between abnormal glucose regulation and family history of diabetes, separately and in combination with lifestyle risk factors. Subjects and methods This cross-sectional study comprised 3,128 men and 4,821 women, aged 35-56 years, half with a family history of diabetes. Oral glucose tolerance testing identified subjects with previously undiagnosed prediabetes (IFG, IGT) and type 2 diabetes. Information on lifestyle factors was obtained by questionnaire. Biological interaction was measured with the synergy index. Results A family history of diabetes conferred a higher odds ratio (OR) for type 2 diabetes in men (OR=3.1, 95% CI 1.7-5.6) than in women (OR=1.7, 95% CI 1.0-3.0), and the synergy index was 2.8 (95% CI 0.9-9.0), suggesting interaction between a family history of diabetes and sex. For prediabetes and diabetes combined, the synergy index was 1.7 (1.0-2.8). Exposure to only one lifestyle risk factor (obesity, physical inactivity, smoking or low sense of coherence [a psychosocial index]) increased the risk to a similar extent in men and women. Combined exposure to a family history of diabetes and lifestyle-related risk factors had a greater effect on type 2 diabetes than any of these factors alone, especially in men. However, analysis of interaction between a family history of diabetes and the lifestyle factors did not indicate any interaction for diabetes, but did indicate interaction for a family history of diabetes and obesity in women with prediabetes. Conclusions/interpretation Our data suggest a more pronounced effect of a family history of diabetes on the risk of type 2 diabetes in men than in women. While both a family history of diabetes and lifestyle risk factors had effects on type 2 diabetes, irrespective of sex, these effects did not appear to interact.

show abstract

“…A number of studies suggest that psychosocial stress plays an important role in the development of diabetes (3)(4)(5)(6)(7)(8). Many American Indians live in pervasively adverse social and physical environments that place them at high risk to stress exposure (9,10).…”

mentioning

confidence: 99%

Stress Burden and Diabetes in Two American Indian Reservation Communities

Jiang

Beals²,

Whitesell³

et al. 2008

Diabetes Care

View full text Add to dashboard Cite

OBJECTIVE—To examine the association between psychosocial stress and diabetes in two American Indian reservation communities (Northern Plains and Southwest). RESEARCH DESIGN AND METHODS—The American Indian Services Utilization, Psychiatric Epidemiology, Risk and Protective Factors Project (AI-SUPERPFP), a cross-sectional probability sample survey, interviewed 3,084 randomly selected members of two American Indian tribal groups. Included were a psychiatric epidemiological interview, a physical health problems checklist, and an extensive sociodemographic section. RESULTS—Stress was common in these reservation communities, and the stress burden was greater among those with diabetes. After adjusting for sociodemographic characteristics, early-life interpersonal trauma and community family dysfunction were significantly associated with increased odds of diabetes in the Northern Plains, while discrimination and community addiction problems were significantly associated with increased odds of diabetes in the Southwest. CONCLUSIONS—A number of psychosocial stresses were significantly associated with increased odds of self-reported diabetes in these two American Indian communities.

show abstract

Work Stress and Low Sense of Coherence Is Associated With Type 2 Diabetes in Middle-Aged Swedish Women

Cited by 150 publications

References 25 publications

Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men

Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men

The impact of family history of diabetes and lifestyle factors on abnormal glucose regulation in middle-aged Swedish men and women

Stress Burden and Diabetes in Two American Indian Reservation Communities

Contact Info

Product

Resources

About