“…Osteoporosis is one of the main geriatric problems worldwide, occurring frequently in postmenopausal females (1), while postmenopausal osteoporosis is a common systemic skeletal system disease occurring in middle-aged females. The functional decline of the ovaries leads to decreased estrogen levels, which triggers osteoporotic changes (2).…”
Abstract. Large animal models of osteoporosis are essential for osteoporosis research. However, the time required to establish an accurate osteoporosis model is unknown. Therefore, the aim of the present study was to establish a large animal model of osteoporosis in goats. In total, 14 Chinese goats were divided into an ovariectomized (OVX, n=7) or sham-operated (SHAM, n=7) group. Vertebral bodies were used to measure the bone mineral density (BMD) prior to the ovariectomy and at 24 months after the ovariectomy. In addition, the BMD of the femoral neck, femoral diaphysis and tibial diaphysis were measured 24 months postoperatively. Bone samples from the vertebral body, femoral head and femoral neck were scanned by micro-computed tomography (CT) to visualize the trabecular and cortical microstructure. Furthermore, the vertebral body, femoral head, femoral neck and tibial diaphysis were analyzed for mechanical strength. The BMD of vertebral body of the OVX group decreased significantly (P<0.01) at 24 months after the ovariectomy when compared with the baseline measurements. Micro-CT scans of the vertebral body revealed that the bone volume fraction, trabecular number, trabecular thickness and the degree of anisotropy decreased by 37.1, 36.7, 10.5 and 16.5%, respectively (P<0.01) in the OVX group when compared with the SHAM group. Additionally, the specific bone surface and trabecular spacing significantly increased by 37.7 and 62%, respectively in the OVX group (P<0.001). Cortical bone porosity in the vertebral body and femoral neck was greater in the OVX group when compared with the SHAM group (P<0.05). In addition, mechanical testing revealed a statistically significant difference between the vertebral bodies of the OVX group and the SHAM group. In conclusion, the present study demonstrated that an ovariectomy was able to induce significant osteoporosis and deterioration of mechanical properties in the bones of goats.
“…Osteoporosis is one of the main geriatric problems worldwide, occurring frequently in postmenopausal females (1), while postmenopausal osteoporosis is a common systemic skeletal system disease occurring in middle-aged females. The functional decline of the ovaries leads to decreased estrogen levels, which triggers osteoporotic changes (2).…”
Abstract. Large animal models of osteoporosis are essential for osteoporosis research. However, the time required to establish an accurate osteoporosis model is unknown. Therefore, the aim of the present study was to establish a large animal model of osteoporosis in goats. In total, 14 Chinese goats were divided into an ovariectomized (OVX, n=7) or sham-operated (SHAM, n=7) group. Vertebral bodies were used to measure the bone mineral density (BMD) prior to the ovariectomy and at 24 months after the ovariectomy. In addition, the BMD of the femoral neck, femoral diaphysis and tibial diaphysis were measured 24 months postoperatively. Bone samples from the vertebral body, femoral head and femoral neck were scanned by micro-computed tomography (CT) to visualize the trabecular and cortical microstructure. Furthermore, the vertebral body, femoral head, femoral neck and tibial diaphysis were analyzed for mechanical strength. The BMD of vertebral body of the OVX group decreased significantly (P<0.01) at 24 months after the ovariectomy when compared with the baseline measurements. Micro-CT scans of the vertebral body revealed that the bone volume fraction, trabecular number, trabecular thickness and the degree of anisotropy decreased by 37.1, 36.7, 10.5 and 16.5%, respectively (P<0.01) in the OVX group when compared with the SHAM group. Additionally, the specific bone surface and trabecular spacing significantly increased by 37.7 and 62%, respectively in the OVX group (P<0.001). Cortical bone porosity in the vertebral body and femoral neck was greater in the OVX group when compared with the SHAM group (P<0.05). In addition, mechanical testing revealed a statistically significant difference between the vertebral bodies of the OVX group and the SHAM group. In conclusion, the present study demonstrated that an ovariectomy was able to induce significant osteoporosis and deterioration of mechanical properties in the bones of goats.
“…Moreover, POI women have to be informed of objective benefice of HRT. Indeed, young women with untreated POI or early menopause are at increased risk of developing osteoporosis, along with cardiovascular disease and cognitive impairment [6,10,11,17–20]. In patients with Turner syndrome, an observational study showed that nearly 20% of patients did not receive HRT because of non-adherence [21].…”
Section: Discussionmentioning
confidence: 99%
“…A very early menopause has a potentially devastating effect on long-term bone health [6,10,11,23,24]. Late menarche and menstrual irregularity are also been showed to be important risk factors for osteoporosis development [25].…”
Section: Discussionmentioning
confidence: 99%
“…Optimal management of POI women encompasses estrogen deficiency compensation by estrogen replacement therapy, and management of the infertility, for which oocyte donation or adoption could be proposed. Some studies have shown that women with POI have lower bone mineral density [3,10,11]. Nevertheless, the outcome of these women in terms of medical care, hormonal replacement therapy compliance and bone health status is not known.…”
Premature ovarian insufficiency leads to through infertility and estrogen deficiency. Optimal management encompasses estrogen replacement therapy. Long-term outcome of women with POI is not known. We design a study to evaluate the medical care, hormone replacement therapy compliance and bone mineral density (BMD) in POI women with at least a five-year follow-up after the first evaluation. One hundred and sixty-two patients (37.3±8.0 years) were evaluated (follow-up 7.9±2.8 years). Sixty-nine patients (42.6%) had stopped their hormone replacement therapy (HRT) for at least one year during the follow up period. BMD determination at initial evaluation and at follow-up visit was completed in 92 patients. At first evaluation, 28 patients (30%) had osteopenia and 7 (8%) had osteoporosis. At follow up, 31 women (34%) had BMD impairment with osteopenia in 61% and osteoporosis in 5%. In univariate analysis and multivariate analysis, there was a significant loss of femoral BMD in women who had stopped their HRT for over a year. In conclusion, this first study concerning long-term follow-up of POI patients shows the poor compliance to their HRT, despite its importance in the prevention of bone demineralization. This study reinforces the need for follow up and specific care for POI women.
“…10 All antineoplastic drugs, especially alkylating agents, have dose-dependent toxic effects on both oocytes and granulosa cells. 11,12 Alkylating agents can damage primordial follicles through apoptotic cell death, resulting in destruction of ovarian reserve. 13 Although BU is considered to be highly gonadotoxic, especially in women, there are conflicting results…”
ABSTARCATInfertility is a major late side effect after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, healthy pregnancies and births were reported previously. We retrospectively evaluated the fertility of 107 adult patients who underwent Allo-HSCT (median age: 32.3) between 1989-2012 at our center and survived 2 years or more after transplantation. From totally 29 pregnancies (21 partners of male patients vs 8 female patients), 6 of the female patients (14%) and 20 of the male patients (45%), had a child after Allo-HSCT. The benign nature of the initial diagnosis, lack of chemotherapy regimen before transplantation, early age and no relapse of the primary disease contribute to fertility in our study. No relation was detected between the myeloablative conditioning regimen, radiotherapy prior to Allo-HSCT, TBI usage and frequency, and development of acute and chronic GVHD with infertility.
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