Women with polycystic ovary syndrome wedge resected in 1956 to 1965: A long-term follow-up focusing on natural history and circulating hormones

Dahlgren, Eva; Johansson, Saga; Lindstedt, Göran; Knutsson, Folke; Odén, Anders; Janson, Per Olof; Mattson, Lars-Åke; Crona, N.; Lundberg, Per‐Arne

doi:10.1016/0020-7292(92)90704-m

Cited by 297 publications

(282 citation statements)

References 21 publications

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“…Longitudinal data are therefore warranted to investigate which factor, namely progressive insulin resistance and=or subtle alterations of insulin secretion, may predict the well-documented susceptibility of obese PCOS women toward type 2 diabetes. 4 Although PCOS per se may be associated with alterations of both lipid and lipoprotein metabolism, the presence of obesity usually leads to a more atherogenic lipoprotein pattern. A greater reduction of highdensity lipoproteins (HDL)s 44,73 together with a higher increase of both triglycerides 44,67,73 and total cholesterol 44 levels were in fact observed in obese with respect to the normal-weight PCOS women.…”

Section: Androgen Abnormalitiesmentioning

confidence: 99%

“…This represents an important factor in the evaluation of PCOS throughout life, and implies that the PCOS by itself may not be a hyperandrogenic disorder exclusively related to young and fertile women, but may have some health implications later in life. 4 Obesity is very common clinical feature in women affected by PCOS. In fact, approximately 50% of PCOS women are overweight or obese 5 and the history of the weight gain frequently precedes the onset of oligomenorrhea and hyperandrogenism, suggesting a pathogenetic role of obesity in the subsequent development of the syndrome.…”

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confidence: 99%

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Obesity and the polycystic ovary syndrome

et al. 2002

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The polycystic ovary syndrome (PCOS) is a condition characterized by hyperandrogenism and chronic oligo-anovulation. However, many features of the metabolic syndrome are inconsistently present in the majority of women with PCOS. Approximately 50% of PCOS women are overweight or obese and most of them have the abdominal phenotype. Obesity may play a pathogenetic role in the development of the syndrome in susceptible individuals. In fact, insulin possesses true gonadotrophic function and an increased insulin availability at the level of ovarian tissue may favour excess androgen synthesis. Obesity, particularly the abdominal phenotype, may be partly responsible for insulin resistance and associated hyperinsulinemia in women with PCOS. Therefore, obesity-related hyperinsulinemia may play a key role in favouring hyperandrogenism in these women. Other factors such as increased estrogen production rate, increased activity of the opioid system and of the hypothalamic-pituitary-adrenal axis, decreased sex hormone binding globulin synthesis and, possibly, high dietary lipid intake, may be additional mechanisms by which obesity favours the development of hyperandrogenism in PCOS. Irrespective of the pathogenetic mechanism involved, obese PCOS women have more severe hyperandrogenism and related clinical features (such as hirsutism, menstrual abnormalities and anovulation) than normal-weight PCOS women. This picture tends to be more pronounced in obese PCOS women with the abdominal phenotype.Body weight loss is associated with beneficial effects on hormones, metabolism and clinical features. A further clinical and endocrinological improvement can also be achieved by adding insulin-sensitizing agents and=or antiandrogens to weight reduction programmes. These obviously emphasize the role of obesity in the pathophysiology of PCOS.

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Section: Androgen Abnormalitiesmentioning

confidence: 99%

mentioning

confidence: 99%

Obesity and the polycystic ovary syndrome

et al. 2002

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“…This syndrome is present in 5% to 8% of women of reproductive age and also associated with insulin resistance and obesity. Insulin resistance has potential longterm health consequences and this fact has led to suggest that women with PCOS may be at increased risk of cardiovascular disease later in their lives, especially if disturbances of lipid and carbohydrate metabolism persist after the menopause [1,2]. The etiology of this syndrome remains unclear but there are strong evidences for a major genetic component in the etiology of PCOS.…”

Section: Introductionmentioning

confidence: 99%

Familial associations between polycystic ovarian syndrome and common diseases

Moini

Eslami

2009

J Assist Reprod Genet

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“…Early reports have suggested that women with PCOS may develop menopause at a later age than control women (40). Yet, more recent studies have shown that menopausal age is similar in women with or without PCOS (39).…”

Section: Body Weight and Diabetes In Post-menopausal Agementioning

confidence: 99%

“…Further, it has been shown that postmenopausal women with PCOS have higher prevalence of obesity and type-2 diabetes than postmenopausal controls (39,40). Both disorders may contribute to the increase of cerebro-vascular and cardio-vascular events in this category of subjects (39).…”

Section: Body Weight and Diabetes In Post-menopausal Agementioning

confidence: 99%

Long-term consequences of polycystic ovary syndrome on cardiovascular risk

Rizzo

Berneis²,

Spinas³

et al. 2009

Fertility and Sterility

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2 CAPSULEPostmenopausal women with PCOS have increased cerebro-vascular events and cardiovascular morbidity. Our best long-term strategy is information, acknowledging women with PCOS of their risk for metabolic and cardiovascular diseases. 3 ABSTRACTMost available data suggest that the prevalence of cardiovascular diseases in women with polycystic ovary syndrome (PCOS) is smaller than what expected on the basis of the risk calculation during fertile age; therefore, we need many more studies on their long term cardiovascular consequences although evidence is accumulating that women with PCOS at postmenopausal age have an increase in cerebro-vascular events and in cardiovascular morbidity. These events are partially related to the persisting hyperandrogenism but are mostly correlated to the excessive body weight (mainly to the visceral obesity); this suggests that our best long term strategy is the information, acknowledging women with PCOS of their high risk for metabolic and cardiovascular diseases.

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Women with polycystic ovary syndrome wedge resected in 1956 to 1965: A long-term follow-up focusing on natural history and circulating hormones

Cited by 297 publications

References 21 publications

Obesity and the polycystic ovary syndrome

Obesity and the polycystic ovary syndrome

Familial associations between polycystic ovarian syndrome and common diseases

Long-term consequences of polycystic ovary syndrome on cardiovascular risk

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