Women with polycystic ovary syndrome are often depressed or anxious—A case control study

Månsson, Mattias; Holte, Jan; Landin‐Wilhelmsen, Kerstin; Dahlgren, Eva; Johansson, Anette; Landén, Mikael

doi:10.1016/j.psyneuen.2008.06.003

Cited by 215 publications

(244 citation statements)

References 50 publications

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“…It has been shown that PCOS-diagnosed women with high anxiety scores have significantly elevated HOMA-IR and FAI values in comparison with PCOS-diagnosed women with low anxiety scores, independently of BMI (22). In the present study we did not find any correlation between HOMA-IR levels and depression or anxiety.…”

Section: Discussioncontrasting

confidence: 75%

Depression, anxiety, and their relation with clinical parametersand androgen levels in hirsute women

Irak¹,

Yavuz²,

Doğan³

et al. 2016

Turk J Med Sci

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Background/aim: The purpose of this study was to assess the prevalence of anxiety and depression among patients with hirsutism and to evaluate the relationships of anxiety and depression with clinical parameters and androgen levels. Materials and methods:One hundred and seven women with hirsutism were enrolled in the study. All participants completed standardized questionnaires to assess depression (Beck Depression Inventory (BDI)) and anxiety (Beck Anxiety Inventory (BAI)). The Ferriman-Gallwey (FG) scores, body mass indexes (BMIs), homeostatic model assessments of insulin resistance (HOMA-IR), and serum androgen levels of all patients were obtained.Results: Seventy-four of the 107 patients (69.15%) had BDI scores indicating depression, and 47 of the 107 patients (43.9%) had BAI scores indicating anxiety disorders. No difference was found between high BAI and normal BAI patients related to BMI, age, FG scores, testosterone levels, and HOMA-IR levels (P > 0.05), and no difference was found between high BDI and normal BDI patients related to BMI, age, FG scores, free testosterone levels, and HOMA-IR levels. There was a positive correlation between BDI scores and dehydroepiandrosterone sulphate (DHEA-S) levels (P < 0.01). Conclusion:We found considerable amounts of depression, anxiety, and the coexistence of depression and anxiety in patients with hirsutism. Depression and the severity of depressive symptoms were positively correlated with DHEA-S levels.

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Section: Discussioncontrasting

confidence: 75%

Depression, anxiety, and their relation with clinical parametersand androgen levels in hirsute women

Irak¹,

Yavuz²,

Doğan³

et al. 2016

Turk J Med Sci

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“…Adrenal Hyperplasia (CAH) or Polycystic Ovary Syndrome (PCOS) revealed higher rates of anxiety disorders (Barry et al, 2011;Mansson et al, 2008;Mueller et al, 2010) and cognitively faster processing of threat in some cases (Ernst et al, 2007;Mueller et al, 2009a). Such results strongly support the hypothesis that mood and anxiety disorders are often associated with disorders of gonadal dysregulation.…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 83%

“…psychopathologies include anxiety and depression as well as eating disorders relative to women without this condition (Barry et al, 2011;Mansson et al, 2008).…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

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Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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Despite increasing acknowledgement of hormonal contributions to mood and anxiety disorders, the underlying mechanisms by which gonadal hormones influence psychopathology-related behaviours remain unknown. This review focuses on recent research that examines the influence of gonadal steroid hormones, including androgens, estrogens, and progesterone, on mood and anxiety-related behaviours in human health and disease. To this aim, the literature was surveyed for studies that assess conditions with suspected underlying hormonal imbalances in otherwise healthy participants (e.g., Premenstrual Dysphoric Disorder, Postmenopausal Depression,) as well as conditions linked to congenital endocrine abormalities (e.g., Turner Syndrome, Klinefelter Syndrome, Polycystic Ovary Syndrome, Congenital Adrenal Hyperplasia, Familial Male Precocious Puberty, Androgen Insensitivity Syndrome). Furthermore, to better inform clinical work and to create a translational bridge, a second goal was to set human psychopathologies and animal models of these conditions side-by-side. In the second part of the review, based on consistencies revealed in the existing literature across conditions, a new model for the impact of gonadal hormones on anxious and depressed behavioural states is proposed. Finally, we conclude by proposing directions for future research, including the development of specific tasks suitable for cross-species comparisons to increase our knowledge of the role of gonadal hormones in mood and anxiety.

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“…Without adjusting for the confounding effect of overweight, women with PCOS have higher lifetime incidence of social phobia and eating disorders and more often report previous suicide attempts than healthy controls [29]. Current and lifetime use of antidepressants and anxiolytic drugs also appear to be more common in the PCOS group [29].…”

Section: Pcos Diagnosismentioning

confidence: 99%

Metabolic Aspects of Polycystic Ovary Syndrome

2015

Postgraduate Obstetrics & Gynecology

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Women with polycystic ovary syndrome are often depressed or anxious—A case control study

Cited by 215 publications

References 50 publications

Depression, anxiety, and their relation with clinical parametersand androgen levels in hirsute women

Depression, anxiety, and their relation with clinical parametersand androgen levels in hirsute women

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Metabolic Aspects of Polycystic Ovary Syndrome

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