Women with normal glucose tolerance and a history of gestational diabetes show significant impairment of β-cell function at normal insulin sensitivity

Molęda, Piotr; Homa, Katarzyna; Safranow, Krzysztof; Celewicz, Zbigniew; Fronczyk, Aneta; Majkowska, Lilianna

doi:10.1016/j.diabet.2012.11.003

Cited by 14 publications

(11 citation statements)

References 25 publications

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“…Moreover, we observed that women with pGDM had higher rate of I-GTT than non GDM subjects (23.5% vs 13.4). Similarly, and more recently, Molęda and his colleagues [15] reported a lower rate of normoglycaemia, at 60 and 2 h after glucose load, in women who had GDM history (57%) within the last 5–12 years compared to non-GDM women (88%).…”

Section: Discussionmentioning

confidence: 69%

Correlation of serum homocysteine and previous history of gestational diabetes mellitus

Alatab

Fakhrzadeh

Sharifi

et al. 2013

J Diabetes Metab Disord

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BackgroundGestational diabetes mellitus (GDM) is a common pregnancy condition. In this study, the risk of having a history of previous GDM (pGDM) on serum homocysteine level was assessedMethodsBiomedical parameters, serum homocysteine, Insulin, homeostatic model assessment (HOMA) in women with (n = 52) and without pGDM (n = 51) were assessed. According to their current status of Oral Glucose Tolerance Test (GTT), the participants in each group were divided into two subgroups of normal or impaired GTT.ResultsMean serum homocysteine in normal women was 8.56 ± 3.19 vs 11.44 ± 7.34 μmol/L (p < 0.01) in women with pGDM. Two groups had significant differences in respect to serum insulin levels (8.35 ± 5.12 vs 12.48 ± 5.44, p < 0.002), and HOMA-IR (1.90 ± 1.30 vs 2.91 ± 1.30, p < 0.002). In women without pGDM, serum homocysteine in normal and impaired GTT were 7.60 ± 1.69 and 10.52 ± 3.65 μmol/L (p = 0.03), respectively, while in women with pGDM, the figures were 8.38 ± 2.52 and 14.00 ± 10.17 (p < 0.01), respectively. In multi regression analysis an association between history of GDM and homocysteine levels was presented (OR: 7.71, 95% CI: 1.67-35.42, p < 0.001).ConclusionA trend of elevation of homocysteine is presented in women with pGDM, that is more prominent in women with impaired GTT, and shows a significant correlation with history of GDM. Further studies with larger sample size are suggested.

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Section: Discussionmentioning

confidence: 69%

Correlation of serum homocysteine and previous history of gestational diabetes mellitus

Alatab

Fakhrzadeh

Sharifi

et al. 2013

J Diabetes Metab Disord

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“…Our initial search yielded 7970 publications, of which 109 articles were reviewed in full and 43 studies were included in the final analysis [3,11,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55]. Forty studies reported on T2DM [3,11,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43…”

Section: Resultsmentioning

confidence: 99%

The Risk for Glucose Intolerance after Gestational Diabetes Mellitus since the Introduction of the IADPSG Criteria: A Systematic Review and Meta-Analysis

Benhalima

Lens

Bosteels

et al. 2019

JCM

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The aim of the study was to assess the postpartum risk for glucose intolerance since the introduction of the ‘International Association of Diabetes and Pregnancy Study Groups’ (IADPSG) criteria for gestational diabetes mellitus (GDM). Studies published since 2010 were included, which evaluated the risk for type 2 diabetes mellitus (T2DM), impaired glucose tolerance (IGT), and cardiovascular (CV) events in women with previous GDM compared to normal glucose tolerant women. We included forty-three studies, evaluating 4,923,571 pregnant women of which 5.8% (284,312) had a history of GDM. Five studies used IADPSG criteria (n = 6174 women, 1314 with GDM). The overall pooled relative risk (RR) for postpartum T2DM was 7.42 (95% CI: 5.99–9.19) and the RR for postpartum T2DM with IADPSG criteria was 6.45 (95% CI: 4.74–8.77) compared to the RR of 9.08 (95% CI: 6.96–11.85; p = 0.17) for postpartum T2DM based on other diagnostic criteria. The RR for postpartum IGT was 2.45 (95% CI: 1.92–3.13), independent of the criteria used. None of the available studies with IADPSG criteria evaluated the risk for CV events. Women with a history of GDM based on the IADPSG criteria have a similarly increased risk for postpartum glucose intolerance compared to GDM based on other diagnostic criteria. More studies with GDM based on the IADPSG criteria are needed to increase the quality of evidence concerning the long-term metabolic risk.

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“…Persistent high insulin resistance during pregnancy can stress and exacerbate pancreatic cells' damage [20][21]. Multiple studies revealed that women with GDM had varying insulin resistance levels and reduced insulin sensitivity after delivery [22][23][24][25]. A Greek study found that women with previous GDM presented various degrees of impaired fasting glucose and impaired glucose tolerance in postpartum [26].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics, gestational weight gain and pregnancy outcomes in women with a history of gestational diabetes mellitus

Liang

Zheng

Liu

et al. 2021

Preprint

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Background Pregnant women with a history of gestational diabetes mellitus (GDM) are at high risk of GDM. It is unclear whether this population has pregnancy characteristics different from the general population. Whether these features affect the perinatal outcome has not yet been elucidated. Methods A retrospective study was conducted, including baseline characteristics, laboratory data, gestational weight gain (GWG), and pregnancy outcomes of 441 pregnant women with prior GDM. Besides, 1637 women without a history of GDM treated in the same period were randomly selected as the control group. The above indicators of the two groups were compared. Multivariable logistic regression analysis was performed to investigate how GWG was associated with perinatal outcomes for previous GDM women. Results Among women with GDM history, triglycerides (TG) and fasting plasma glucose (FPG) in the 1 st trimester were higher than those without GDM history. GWG was lower in women with prior GDM relative to the control group at various pregnancy stages. However, women with GDM history had a higher risk of developing GDM (OR 3.25, 95% CI 2.26–4.68) and pregnancy-induced hypertension (OR 1.50, 95% CI 1.05–2.45). In women with previous GDM, excessive GWG before OGTT exhibited a positive correlation with pregnancy-induced hypertension (OR 1.47, 95% CI 1.05–3.32), while inadequate GWG was not a protective factor for GDM and pregnancy-induced hypertension. Conclusion Women with prior GDM have glucose and lipid metabolism disorders in the 1st trimester. Limited reduction of GWG before OGTT was insufficient to offset the adverse effects of glucose and lipid metabolism disorders in women with previous GDM. Relevant interventions may be required at early stage or even before pregnancy.

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Women with normal glucose tolerance and a history of gestational diabetes show significant impairment of β-cell function at normal insulin sensitivity

Cited by 14 publications

References 25 publications

Correlation of serum homocysteine and previous history of gestational diabetes mellitus

Correlation of serum homocysteine and previous history of gestational diabetes mellitus

The Risk for Glucose Intolerance after Gestational Diabetes Mellitus since the Introduction of the IADPSG Criteria: A Systematic Review and Meta-Analysis

Clinical characteristics, gestational weight gain and pregnancy outcomes in women with a history of gestational diabetes mellitus

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