Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium

Oosterlynck, Didier J.; Cornillie, Freddy; Waer, Mark; Vandeputte, Michel; Koninckx, Philippe

doi:10.1016/s0015-0282(16)54414-8

Cited by 405 publications

(220 citation statements)

References 11 publications

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“…It is well known that women with endometriosis have a decreased cellular immunity and a decreased NK activity in peripheral blood and in peritoneal fluid (8)(9)(10). Stress, which is followed by increased cortisol levels, inhibits NK cell activity.…”

Section: Parameters Analyzedmentioning

confidence: 99%

“…The main conclusions of these studies indicate an increased number of activated macrophages and their immune mediators, which may substantially interfere with reproduction at various levels, including gamete function, fertilization, embryo development, and embryo implantation. Furthermore, women with endometriosis have reduced cellular immunity and more specifically a decreased natural killer (NK) activity in peripheral blood and in peritoneal fluid (8)(9)(10). It is also well known that parameters associated with stress can significantly alter several immunological parameters, including the number of cells as well as their function (for a review, see Ref.…”

Section: Introductionmentioning

confidence: 99%

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Prolactin and cortisol levels in women with endometriosis

Lima

Moura

Silva

2006

Braz J Med Biol Res

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Section: Parameters Analyzedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prolactin and cortisol levels in women with endometriosis

Lima

Moura

Silva

2006

Braz J Med Biol Res

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“…In peritoneal fluid of women with endometriosis, decreased natural killer (NK) cell activity (Oosterlynck et al 1991;Ho et al 1995), dysfunction of T lymphocytes (Ho et al 1996;Szyllo et al 2003), infiltrating macrophage (Bacci et al 2009) as well as aberrant concentrations of immune-related cytokines (Ho et al 1997) have been reported in the past two decades. Thus, it has been proposed that an impaired immunological clearance of endometrial fragments shed into the peritoneal cavity may facilitate the implantation of endometrial cells in ectopic locations and result in endometriosis.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-12 inhibits development of ectopic endometriotic tissues in peritoneal cavity via activation of NK cells in a murine endometriosis model

et al. 2011

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Involvement of impaired peritoneal immunosurveillance systems has been well established in the pathology of endometriosis. On the other hand, it has been observed that peritoneal administration of IL-12 suppress development of endometriotic lesions in a mouse endometriosis model. We investigated the effect of peritoneal administration of IL-12 on the peritoneal immunosurveillance system regarding NK cells in the mouse model. Treating the endometrialtissue challenged mice with IL-12 for 5 consecutive days, from day -2 to day 2 (implantation of the endometrial tissues was done on day 0), cytotoxicity of splenic NK cells was enhanced immediately after the administration, on day 3, and development of the endometriotic lesions was reduced on day 21. In vivo NK cell depletion by administration of anti-IL-2Rb mAb resulted in reduction of the cytotoxicity of splenic NK cells concomitant with a significant attenuation of suppressive effect of IL-12 on development of endometriotic lesions. Therefore, it was suggested that IL-12 suppresses development of endometriotic lesions via activation of NK cells, and that NK cells are involved in the primary defense for the development of endometriotic lesions.

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“…Deficient cellular immunity may result in the inability to recognize endometrial tissue in abnormal locations (Steele et al 1984). A low level of natural killer cell activity may result in decreased cytotoxicity for autologous endometrium (Oosterlynck et al 1991). It has been reported that there is an increase of leukocytes and macrophages in the peritoneal cavity and ectopic endometrium of women with endometriosis (Dmowski et al 1994).…”

Section: Pathogenesis Of Endometriosismentioning

confidence: 99%

Primate Model Research for Endometriosis

Yamanaka

Kimura

Takebayashi

et al. 2012

Tohoku J. Exp. Med.

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Non-Human Primate Models of Endometriosis 95 Tohoku J. Exp. Med., 2012, 226, 95-99 95 Received November 29, 2011; revision accepted for publication January 6, 2012January 6, . doi: 10.1620 Endometriosis is defined as the existence of endometrial tissue outside the uterine cavity, and it includes a chronic, inflammatory reaction associated with female infertility and pelvic pain. Endometriosis occurs in 7 to 10% of women. Although it has been studied for more than 50 years, the pathogenesis and development of endometriosis are still poorly understood. There is no curative therapy for endometriosis, which often recurs after surgical or medical treatment. There is a consensus that the adverse current of menstrual blood plays a crucial role in the development of endometriosis. This places a major limitation on research using rodent models of endometriosis, although these are still widely employed, because rodents do not menstruate and endometriosis does not occur spontaneously in these animals. In fact, menstruation and spontaneous endometriosis only occur in women and some non-human primates, making models that employ non-human primates the best animal models for research into the pathogenesis, pathophysiology, spontaneous onset, and treatment of endometriosis. This review assesses the effectiveness and potential of the non-human primate models of endometriosis. It also describes the current findings and theories on the pathogenesis of endometriosis that have been obtained by research using non-human primates.

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Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium

Cited by 405 publications

References 11 publications

Prolactin and cortisol levels in women with endometriosis

Prolactin and cortisol levels in women with endometriosis

Interleukin-12 inhibits development of ectopic endometriotic tissues in peritoneal cavity via activation of NK cells in a murine endometriosis model

Primate Model Research for Endometriosis

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