Women With Eating Disorder Tendencies Display Altered Cardiovascular, Neuroendocrine, and Psychosocial Profiles

Koo-Loeb, Jeannie H.; Costello, Nancy; Light, Kathleen C.; Girdler, Susan S.

doi:10.1097/00006842-200007000-00013

Cited by 72 publications

(60 citation statements)

References 52 publications

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“…[55][56][57] To date, only three studies have examined stress-induced cardiovascular responses in women with eating disorder tendencies or BN: they have provided conflicting results for heart rate and blood pressure reactivity. [58][59][60] To our knowledge, no studies have addressed cardiac parasympathetic activation during mental stress in BN. Consequently, a conclusive comparison with BN subjects regarding parasympathetic regulation in relation to mental stress is currently not possible.…”

Section: Discussionmentioning

confidence: 99%

Cardiac parasympathetic regulation in obese women with binge eating disorder

Schild

Schellberg

et al. 2005

Int J Obes

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Objective: Obese individuals with a binge eating disorder (BED) differ from obese non-binge eaters (NBED) with respect to (a) eating behaviour, (b) psychiatric comorbidity and (c) level of psychosocial distress. The aim of the study was to explore whether these three factors have an influence on cardiac parasympathetic function, that is independent of obesity: as alterations in cardiac parasympathetic function may have a role in the higher cardiovascular mortality that is present in obese individuals. Methods: In total, 38 obese women (BMI430 kg/m 2 ), with a BED and 34 age and BMI matched healthy controls (NBED) completed a laboratory stress protocol that incorporated a baseline resting period, Head-up Tilt Testing (HUT) and two challenging mental tasks. Heart rate and blood pressure were measured continuously during the protocol. Parasympathetic cardiac regulation was assessed as the high frequency component of heart rate variability (HRV-HF). Results: Mental challenge led to an augmented reduction of HRV-HF in obese binge eaters, which was linked to the binge eating frequency and hunger perception, but not to psychiatric comorbidity. During baseline conditions and HUT, no significant differences in parasympathetic measures were observed between the two subject groups. Conclusion: Subjects with a BED showed greater reduction in parasympathetic cardiac control (HRV-HF) during mental stress, suggesting higher stress vulnerability in women with a BED. Longitudinal investigations are necessary to evaluate whether this is associated with an increased cardiovascular mortality.

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Section: Discussionmentioning

confidence: 99%

Cardiac parasympathetic regulation in obese women with binge eating disorder

Schild

Schellberg

et al. 2005

Int J Obes

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“…All assays were performed by trained technicians at the UNC General Clinical Research Center as previously described (Girdler et al, 2003;Koo-Loeb, Costello, Light, & Girdler, 2000).…”

Section: Cardiovascular Urine and Blood Samplingmentioning

confidence: 99%

Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy

Light

Grewen

Amico

et al. 2004

Addictive Behaviors

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In animals, oxytocin enhances maternal behavior and lowers blood pressure (BP) and negative affect, while parturitional cocaine disrupts oxytocin activity and increases maternal neglect and aggression. Thus, we compared oxytocin, BP, maternal behavior, and affect in mothers of infants who used cocaine (cocaine, n = 10) or did not (no drug, n = 25) during pregnancy. Laboratory BP and circulating oxytocin, catecholamines, and cortisol were examined before and during a speech stressor on 2 days, with vs. without prestress baby holding. Ambulatory monitoring assessed BP, urinary norepinephrine, and cortisol for 24 h at home. The cocaine group had lower oxytocin levels, greater hostility and depressed mood, less support from others and mastery over life events, higher BP during all events of testing without the baby, and higher ambulatory BP and urinary norepinephrine at home, while cortisol and epinephrine responses were blunted. Although they tended to hold their babies less often at home, baby holding in the laboratory led to decreased BP in cocaine mothers who then did not differ from no-drug mothers in BP or observed affect.

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“…Stress plays a substantial role in disordered eating (Crowther and Chernyk, 1986;Lacey et al, 1986;Koo-Loeb et al, 2000). Disordered eating, particularly bulimia nervosa, is associated with increased negative perceptions of daily life stress and decreased coping skills (Crowther and Chernyk, 1986;Lo Sauro et al, 2008).…”

Section: Introductionmentioning

confidence: 99%