Women with clinically significant hirsutism always have detectable endocrinological abnormalities

Alkhawajah, Mohammad M.

doi:10.1016/s0926-9959(97)00117-7

Cited by 2 publications

(5 citation statements)

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“…In our series, we found that over half of the patients in both PCOS and IH had acne, an observation similar to others. 6 Nevertheless, there were no differences in metabolic data amongst the groups, which was similar to the report by Taponen et al 21 but different from others. 22 This disparity might be due to a higher prevalence of metabolic syndrome in our study population.…”

Section: Discussionsupporting

confidence: 86%

“…Other etiologies of hirsutism were not common in our study group, which is reflected in the observations of others in the region. 5 , 6 Of the less common causes, LOCAH was found in 4% of patients, higher than the 1.6% reported in Whites, but lower than the 9.5% reported in patients of Mediterranean descent. 29 The relatively higher prevalence of LOCAH in this study may reflect the pattern of referrals received by our unit, which is a referral center for all of Saudi Arabia, and may differ from the prevalence in the community.…”

Section: Discussionmentioning

confidence: 68%

“…For instance, using ultrasound according to European criteria, 91% of cases of hirsutism were due to PCOS in the United Arab Emirates 5 yet others reported a rate as low as 59% in the same region. 6 As far as we know, no study has been conducted using the recently approved consensus opinion on diagnostic criteria for diagnosis of PCOS 7 in Saudi patients. Furthermore, there is no study on the pattern of hirsutism in the local population despite it being commonly seen in clinical practice, with its associated infertility and metabolic syndrome.…”

mentioning

confidence: 99%

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Hirsutism in Saudi females of reproductive age: a hospital-based study

Al-Ruhaily

Malabu

Sulimani

2008

Annals of Saudi Medicine

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BACKGROUNDHirsutism among women of fertile age is commonly seen in clinical practice, but the pattern of the disease in Saudi Arabs has not been studied. The aim of the study was to determine the clinical, biochemical and etiologic features of hirsutism in Saudi females.METHODS101 Saudi Arab women presenting with hirsutism at King Khalid University Hospital, Riyadh, Saudi Arabia, from 1 January 2000 to 31 December 2005 were prospectively assessed using the recently approved diagnostic guidelines for hyperandrogenic women with hirsutism.RESULTSPolycystic ovary syndrome (PCOS) was the cause of hirsutism in 83 patients (82%) followed by idiopathic hirsutism (IH) in 11 patients (11%). Others causes of hirsutism included late onset congenital adrenal hyperplasia in 4 patients (4%), microprolactinoma in 2 (2%) and Cushing’s syndrome in 1 (1%) patient. Age at presentation of PCOS was 24.5±6.6 years (mean±SD) and 51% of the subjects were obese. Furthermore, 74 (89%) of patients with PCOS had an oligo/anovulatory cycle while the remaining 9 patients (11%) maintained normal regular menstrual cycle. Luteinizing hormone and total testosterone were significantly higher in patients with PCOS than in those with IH (P<.05).CONCLUSIONSThe present data show PCOS to be the commonest cause of hirsutism in our clinical practice and PCOS is prominent amongst young obese females. However, further studies on a larger scale are needed to verify our findings.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 68%

mentioning

confidence: 99%

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Hirsutism in Saudi females of reproductive age: a hospital-based study

Al-Ruhaily

Malabu

Sulimani

2008

Annals of Saudi Medicine

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“…The raised LH/FSH ratio in PCOS with hirsutism was found to be statistically significant in our study and was in agreement with the findings of Al-Khawajah et al . [14] and Malik et al . [11] At times LH/FSH ratio may be raised without underlying PCOS as has been seen in 2 (16.67%) patients in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Al-Khawajah et al . [14] also reported raised free testosterone in 30.6% hirsute women with PCOS and they also concluded no association between raised free testosterone and PCOS.…”

Section: Discussionmentioning

confidence: 99%

Hirsutism: A Clinico-investigative Study

et al. 2012

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Background:Hirsutism is a common clinical condition characterized by presence of terminal hair at body sites under androgenic influence. Inspite of the significant worldwide prevalence of hirsutism, studies on hirsutism from India are not many.Objective:To assess the etiology of hirsutism and correlate its severity with underlying causes and various hormone levels.Materials and Methods:In this prospective study, 40 patients of hirsutism enrolled on first come basis were included. All patients underwent detailed clinical assessment and transabdominal ultrasonography. Free and total testosterone, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, luteinizing hormone, follicle stimulating hormone, prolactin, free tri-iodothyronine, free tetra-iodothyronine, and thyroid stimulating hormone, and sex hormone binding globulin were estimated. Forty age-matched controls without features of hyperandrogenemia were included for the comparison.Results:Thirteen (32.5%) patients had mild, 52.5% had moderate whereas 15% had severe hirsutism. Positive family history was documented in 42.5% patients. The clinical features found to be associated with hirsutism included acne (55%), menstrual irregularities (40%), acanthosis nigricans (37.5%), obesity (37.5%), and androgenetic alopecia in 27.5% of patients. Polycystic ovarian syndrome (PCOS) was the underlying cause in 70%, non-classical congenital adrenal hyperplasia and hypothyroidism in 7.5% each whereas idiopathic hirsutism was found in 15% patients.Conclusion:PCOS was the most common cause of hirsutism found in the instant study. Further, there was positive correlation between severity of hirsutism and free testosterone levels.

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Women with clinically significant hirsutism always have detectable endocrinological abnormalities

Cited by 2 publications

References 0 publications

Hirsutism in Saudi females of reproductive age: a hospital-based study

Hirsutism in Saudi females of reproductive age: a hospital-based study

Hirsutism: A Clinico-investigative Study

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