Abstract:Hormone-based contraception disrupts hormonal balance, creating artificial states of anovulation and threatening women's health. We reviewed its main adverse effects and mechanisms on accelerated ovarian aging, mental health (emotional disruptions, depression, and suicide), sexuality (reduced libido), cardiovascular (brain stroke, myocardial infarction, hypertension, and thrombosis), and oncological (breast, cervical, and endometrial cancers). Other “collateral damage” includes negative effects on communicatio… Show more
“…As women’s hormonal health has been gaining prominence in recent research [27], there’s a heightened need for prompt and accessible hormonal testing for gonadal hormones, including estrogen and progesterone, on a global scale.…”
Section: Resultsmentioning
confidence: 99%
“…In this study, the female participants were not required to take the hormonal measurement during a specific phase of their menstrual cycle, as the team wanted to make a more general analysis of estrogen and progesterone. As women's hormonal health has been gaining prominence in recent research [27], there's a heightened need for prompt and accessible hormonal testing for gonadal hormones, including estrogen and progesterone, on a global scale.…”
The objective of this study was to analyze specific biomarkers of interest and find correlations between them using hormonal and cardiovascular measurements. The aim was to explore these physiological patterns during a typical weekday. While this research provides valuable insights into physiological patterns and their potential impact on mental performance, it's essential to note that the study did not aim to diagnose, treat, or propose specific medical interventions based on the findings. Instead, the focus was solely on observational data collection and analysis for the purpose of exploring correlations and understanding daily physiological fluctuations in the context of stress and cognitive performance. Furthermore, the team observed how a low-level stress-triggered cognitive task could alter, and possibly impair, mental performance due to fluctuations in these selected data points. Five (5) adult, healthy participants (aged between 20 and 35 years) volunteered for the small-scaled study (two male and three female). In the current study, participants with larger hormonal and cardiovascular fluctuations during a 5-minute stress-induced task did not achieve as well as those with more stable physiological measurements. Interestingly, a significant peak in cortisol levels was detected during the mental task, likely due to the stress-induced environment. The current, and vastly limited methods used for at-home, hormonal measurements, as well as the slightly unreliable sensor technology used in general pulse oximeters measuring blood oxygen saturation in this trial, indicate the great need to develop new solutions. This includes innovations that would make health monitoring more convenient, while at the same time emphasizing improved mental well-being in daily situations, all without having to continuously wear a gadget to obtain precise insights about multiple health metrics.
“…As women’s hormonal health has been gaining prominence in recent research [27], there’s a heightened need for prompt and accessible hormonal testing for gonadal hormones, including estrogen and progesterone, on a global scale.…”
Section: Resultsmentioning
confidence: 99%
“…In this study, the female participants were not required to take the hormonal measurement during a specific phase of their menstrual cycle, as the team wanted to make a more general analysis of estrogen and progesterone. As women's hormonal health has been gaining prominence in recent research [27], there's a heightened need for prompt and accessible hormonal testing for gonadal hormones, including estrogen and progesterone, on a global scale.…”
The objective of this study was to analyze specific biomarkers of interest and find correlations between them using hormonal and cardiovascular measurements. The aim was to explore these physiological patterns during a typical weekday. While this research provides valuable insights into physiological patterns and their potential impact on mental performance, it's essential to note that the study did not aim to diagnose, treat, or propose specific medical interventions based on the findings. Instead, the focus was solely on observational data collection and analysis for the purpose of exploring correlations and understanding daily physiological fluctuations in the context of stress and cognitive performance. Furthermore, the team observed how a low-level stress-triggered cognitive task could alter, and possibly impair, mental performance due to fluctuations in these selected data points. Five (5) adult, healthy participants (aged between 20 and 35 years) volunteered for the small-scaled study (two male and three female). In the current study, participants with larger hormonal and cardiovascular fluctuations during a 5-minute stress-induced task did not achieve as well as those with more stable physiological measurements. Interestingly, a significant peak in cortisol levels was detected during the mental task, likely due to the stress-induced environment. The current, and vastly limited methods used for at-home, hormonal measurements, as well as the slightly unreliable sensor technology used in general pulse oximeters measuring blood oxygen saturation in this trial, indicate the great need to develop new solutions. This includes innovations that would make health monitoring more convenient, while at the same time emphasizing improved mental well-being in daily situations, all without having to continuously wear a gadget to obtain precise insights about multiple health metrics.
With the increase in the world's population, contraception is crucial in population control strategies. Majority of contraceptives produced today are targeted at women; many of whom experience side effects, leading to the discontinuation of these contraceptives after a year of use. As the use of condoms and vasectomies has been subjected to scrutiny, it is necessary for the development of male birth control (BC). Attempts to achieve this include hormonal and non‐hormonal contraception. Hormonal contraception prevents the production of the sperm in the testes; but this mode of BC has been found to be ineffective while also causing behavioural changes in men. In contrast, non‐hormonal male contraception focuses on rendering the sperm immotile to prevent fertilization post‐copulation. Soluble adenylate cyclase is an area of research that has shown promise in this field. Furthermore, two inhibitors, TDI‐10299 and TDI‐11861, have been developed and tested, with the latter, showing greater potency and longer activity, in mice models. Overall, by developing non‐hormonal male contraceptives, men will have more control over their reproductive health. Nonetheless, before such contraceptives can be made widely available, it is important that further research takes place to ensure the safety and effectiveness of these methods.
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