Women’s cardiovascular health – the cardio-oncologic jigsaw

Ray, M.; Butel-Simoes, L. E.; Lombard, J. M.; Nordman, I. I. C.; Van der Westhuizen, A.; Collins, N. J.; Ngo, D. T. M.; Sverdlov, A. L.

doi:10.1080/13697137.2023.2286382

Cited by 2 publications

(1 citation statement)

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“…Among them, the incidence and prevalence of CVDs in women are higher than that of men, but the mortality is lower than that of men. 1 , 2 , 3 Smoking, alcohol consumption, lack of exercise, diabetes, high blood pressure, hyperlipidaemia and renal insufficiency are the major risk factors associated with death from CVD. Hypertension is the leading risk factor for death from CVDs.…”

Section: Introductionmentioning

confidence: 99%

Recent advances of PIWI‐interacting RNA in cardiovascular diseases

Li,

Wang,

Cheng

et al. 2024

Clinical & Translational Med

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BackgroundThe relationship between noncoding RNAs (ncRNAs) and human diseases has been a hot topic of research, but the study of ncRNAs in cardiovascular diseases (CVDs) is still in its infancy. PIWI‐interacting RNA (piRNA), a small ncRNA that binds to the PIWI protein to maintain genome stability by silencing transposons, was widely studied in germ lines and stem cells. In recent years, piRNA has been shown to be involved in key events of multiple CVDs through various epigenetic modifications, revealing the potential value of piRNA as a new biomarker or therapeutic target.ConclusionThis review explores origin, degradation, function, mechanism and important role of piRNA in CVDs, and the promising therapeutic targets of piRNA were summarized. This review provide a new strategy for the treatment of CVDs and lay a theoretical foundation for future research.Key points piRNA can be used as a potential therapeutic target and biomaker in CVDs. piRNA influences apoptosis, inflammation and angiogenesis by regulating epigenetic modificaions. Critical knowledge gaps remain in the unifying piRNA nomenclature and PIWI‐independent function.

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Section: Introductionmentioning

confidence: 99%