Women in Steady Exercise Research (WISER): Study design and methods

Arikawa, Andrea Y.; O’Dougherty, Maureen; Kaufman, Beth C.; Smith, Arthur A.; Thomas, William; Warren, Meghan; Kurzer, Mindy S.; Schmitz, Kathryn H.

doi:10.1016/j.cct.2010.05.008

Cited by 33 publications

(25 citation statements)

References 22 publications

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“…Details about recruitment, design and methods of the WISER trial have been previously described [3]. Table 1 shows the inclusion criteria for the study.…”

Section: Methodsmentioning

confidence: 99%

Attrition and adherence of young women to aerobic exercise: Lessons from the WISER study

Arikawa

O’Dougherty

Kaufman

et al. 2012

Contemporary Clinical Trials

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The purpose of this report is to identify factors associated with attrition and adherence of young women to a 16-week randomized aerobic exercise intervention on biomarkers associated with breast cancer risk. The exercise group was prescribed a progressive weight-bearing aerobic exercise program consisting of 30 minute workouts, 5 times/wk for 16 weeks. Adherence was calculated as the average minutes of exercise per week during participation in the study. Of the total of 212 women randomized into the exercise intervention 46 dropped out, of which 82.5% dropped out during the earlier stages of exercise suggesting that reasons for withdrawal may have been related to difficulties with initiating physical activity. Time commitment or lack of time was the primary reason for withdrawal. Drop outs reported lower physical activity at baseline than study completers (p=.0007). Although 78% of the 212 randomized participants completed the exercise intervention, only 4.7% of the participants exercised for at least 150 min/wk during the entire study period. Significant predictors of adherence were self-reported physical activity at baseline and depression scores. We conclude that predictors of adherence to exercise in our population of young women are similar to those reported for older adults. We also found that young women are more likely to exercise at moderate to vigorous intensity for 90 to 120 minutes rather than 150 minutes per week, even when participating in a highly structured exercise intervention.

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“…Details about recruitment, design and methods of the WISER trial have been previously described [3]. Table 1 shows the inclusion criteria for the study.…”

Section: Methodsmentioning

confidence: 99%

Attrition and adherence of young women to aerobic exercise: Lessons from the WISER study

Arikawa

O’Dougherty

Kaufman

et al. 2012

Contemporary Clinical Trials

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“…This study was an exercise intervention trial examining the effects of a 16-wk exercise intervention on biomarkers associated with breast cancer risk (the WISER trial), which is described in detail elsewhere (2). A total of 391 participants were randomized into the WISER trial.…”

Section: Study Participantsmentioning

confidence: 99%

Sixteen Weeks of Exercise Reduces C-Reactive Protein Levels in Young Women

Arikawa

Thomas

Schmitz

et al. 2011

Medicine &Amp; Science in Sports &Amp; Exercise

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This study demonstrated that a 16-wk aerobic exercise program significantly decreased levels of CRP in young women, especially in those who were obese. There was no evidence that this effect was mediated by changes in perceived stress, percent body fat, or fitness. These findings suggest that adopting an exercise routine early in life may decrease future risk of breast cancer and other chronic diseases in obese women.

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“…The WISER study investigated the effects of exercise on breast cancer biomarkers in premenopausal women at the University of Minnesota, Twin Cities, between June 2006 and August 2009 [39]. The inclusion criteria were: generally healthy, defined as absence of any chronic disease, premenopausal, age 18–30 years, BMI between 18 and 40 kg/m 2 , sedentary (less than 2 exercise sessions per week), not following any weight loss programs, non-smokers, eumenorrheic and no hormonal contraceptive use for 3 months prior to beginning the study.…”

Section: Methodsmentioning

confidence: 99%

“…We hypothesized that dietary glycemic index and glycemic load would be positively associated with oxidative stress assessed by plasma F 2 -isoprostanes. To test our hypothesis, we evaluated baseline measurements in 306 healthy, premenopausal women who participated in the Women in Steady Exercise Research (WISER) study [39]. …”

Section: Introductionmentioning

confidence: 99%

Consumption of a high glycemic load but not a high glycemic index diet is marginally associated with oxidative stress in young women

et al. 2015

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Research studies have suggested that chronic consumption of high glycemic index foods may lead to chronically high oxidative stress. This is important because oxidative stress is suspected to be an early event in the etiology of many disease processes. We hypothesized that dietary glycemic index and glycemic load were positively associated with oxidative stress assessed by plasma F2-isoprostanes in healthy, premenopausal women (BMI = 24.7 ± 4.8 kg/m2 and age 25.3 ±3.5 years, mean ± SD). We measured plasma F2-isoprostanes in 306 healthy premenopausal women at the baseline visit for the Women In Steady Exercise Research (WISER) study, using gas chromatography-mass spectrometry (GC-MS). Dietary glycemic index and load were calculated from the National Cancer Institute Diet History Questionnaire, and participants were divided into quartiles of dietary glycemic index and of glycemic load. Plasma F2-isoprostanes were compared across quartile groups of dietary glycemic index and glycemic load using linear regression models. Plasma F2-isoprostanes (pg/mL) increased with quartile of glycemic load (test for linear trend, p = .033), and also increased with quartile of glycemic index in participants with BMI ≥ 25 (p = .035) but not in those with BMI < 25 (p = .924). After adjustment for BMI, alcohol consumption and total energy intake, both these positive trends remained marginally significant (p = .123 for quartiles of glycemic index and p=.065 for quartiles of glycemic load).

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Women in Steady Exercise Research (WISER): Study design and methods

Cited by 33 publications

References 22 publications

Attrition and adherence of young women to aerobic exercise: Lessons from the WISER study

Attrition and adherence of young women to aerobic exercise: Lessons from the WISER study

Sixteen Weeks of Exercise Reduces C-Reactive Protein Levels in Young Women

Consumption of a high glycemic load but not a high glycemic index diet is marginally associated with oxidative stress in young women

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