Women hospitalized with atrial fibrillation: Gender differences, trends and outcome from a 20-year registry in a middle eastern country (1991–2010)

Salam, Amar M; Albinali, Hajar; Al-Mulla, Abdul Wahid; Asaad, Nidal; Singh, Rajvir; Al‐Qahtani, Awad; Suwaidi, Jassim Al

doi:10.1016/j.ijcard.2012.10.041

Cited by 21 publications

(15 citation statements)

References 44 publications

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“…5,6,41,49,62 Women with AF also tend to have lower quality of life 15,41,62,63 and are older than men at the time of presentation. 5,9,15,25,30,37,41,64,65 In addition to these clinical differences in presentation between men and women with AF, there are also disparities in the medical management of these patients. These gender differences in the medical management of AF may increase stroke risk differences in men and women.…”

Section: Reasons Why Stroke Risk In Women May Bementioning

confidence: 99%

Gender Differences of Thromboembolic Events in Atrial Fibrillation

Cheng

Kong

2016

The American Journal of Cardiology

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Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and increases the risk of thromboembolism and stroke; however, these risks are not the same for women and men. This review examines the evidence and clinical significance of increased thromboembolic risk in women with AF. The balance of results from over 30 recent studies suggests that female gender is an independent stroke risk factor in AF, and the inclusion of female gender in stroke risk stratification models, such as CHA2DS2-VASc, has improved risk assessment. Reasons for the increased thrombogenicity in women remain incompletely elucidated, but biological factors including increased hypertension, renal dysfunction, and hyperthyroidism in female patients with AF; cardiovascular remodeling; increased hypercoagulability, and estrogen hormone replacement therapy in women have been proposed. More importantly, gender differences exist in medical management of patients with AF, and compared with men, women have been found to have greater thromboembolic risk when not on anticoagulants, but may benefit from greater risk reduction when systemically anticoagulated. In conclusion, increased clinician awareness of these gender differences may help to improve the management of patients with AF.

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Section: Reasons Why Stroke Risk In Women May Bementioning

confidence: 99%

Gender Differences of Thromboembolic Events in Atrial Fibrillation

Cheng

Kong

2016

The American Journal of Cardiology

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“…Another study showed that the prevalence of AF was significantly greater among patients with DM than in non-diabetic patients but after full adjustment for other risk factors, DM was associated with a 26% increased risk of AF only among women [12]. Women with AF are more likely to suffer from DM [13,14]. In a large prospective cohort of initially healthy middle-aged women, baseline DM was a modest but statistically significant risk factor of incident AF after multivariable adjustment [15].…”

Section: Diabetes Mellitus As a Risk Factor For Atrial Fibrillationmentioning

confidence: 99%

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Goudis¹,

Korantzopoulos

Ntalas

et al. 2015

International Journal of Cardiology

115

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“…Birçok çalışmada kadınlar erkeklere göre daha yaşlı idi ve daha çok komorbid risk faktörleri vardı. (3,11,12,21) Keza çalışmamızda da aynı durum söz konusudur. AF'li kadın hasta sayısı 75 yaş üstünde 43, erkeklerde ise 15 idi.Yaş ortalaması ise kadınlarda 76, erkeklerde 70 idi.…”

Section: Discussionunclassified

Women Sex Importance in Stroke Patients with Atrial Fibrillation

Mısırli¹,

Domaç²,

Özkan³

et al. 2014

Türk Beyin Damar Hast Derg

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ÖZETAMAÇ: Atriyal fibrilasyonlu inme hastalarının kadın ve erkek cinsiyeti, yaş, risk faktörleri ve tedavi açısından farklılık gösterip göstermediğine bakıldı. GEREÇ ve YÖNTEM: Son 2 yıllık sürede kliniğimize yatırılan atriyal fibrilasyonlu iskemik inme hastaları başlıca 75 yaş altı ve üstü 2 gruba ayrılarak CHADS2 ve CHA2DS2VASc skorları ile değerlendirildi ve kadın-erkek cinsiyet farklılıklarına bakıldı. BULGULAR: Cinsiyete göre inme oranları özellikle 75 yaş üstünde kadınlarda istatistiksel olarak anlamlı bulundu. Risk faktörlerine de yaşlı kadınlarda daha fazla rastlandı ve CHA2DS2VASc skorları erkeklerden yüksek olduğundan antikoagülan tedaviye daha çok başlandı. Lone atriyal fibrilasyon cinsiyet farkı göstermedi ve hastalara antikoagülan başlanmadı. SONUÇ: Yetmişbeş yaş üstü atriyal fibrilasyonlu kadınlarda risk faktörleri, inme oranı ve antikoagülan başlama oranı yüksek idi . Anahtar Sözcükler: Atriyal fibrilasyon, stroke, kadın, CHADS2, CHA2DS2VASc, risk faktörleri, yaş. WOMEN SEX IMPORTANCE IN STROKE PATIENTS WITH ATRIAL FIBRILLATION ABSTRACTOBJECTIVE: It was shown the differences in age, risk factors and treatment between women and men in stroke patients with atrial fibrillation. MATERIAL and METHODS: The stroke patients with atrial fibrillation who were hospitalized in our department at the last 2 years were seperated into 2 groups of aged above 75 and below 75, investigated with CHADS2 and CHA2DS2VASc scores and looked at the sex differences of women and men. RESULTS: Stroke ratio according to sex was statistically meaningful especially in women above the age of 75. Risc factors also were founded in elderly women and CHA2DS2VASc scores were higher in women than men so more anticoagulan treatment were begun. No differences were shown between sexes at lone atrial fibrillation and no treatment were begun. CONCLUSION: Women with atrial fibrillation had more risk factors, higher stroke rate and higher anticoagulation treatment. Key Words: Atrial fibrillation, stroke, women, CHADS2, CHA2DS2VASc, risk factors, age. GİRİŞAtriyal fibrilasyonun (AF) hakim olduğu kardiak aritmiler ciddi inmelere neden olarak tüm dünyada mortalite ve morbiditede önemli sonuçlar yaratırlar. Tüm yaş gruplarında AF insidansının erkeklerde daha yüksek olmasına rağmen AF'li kadınlar hala bilinmeyen nedenlerle daha yüksek oranlarda inme riski ile karşı karşıyadır ve önlenmesinde AF tedavisi kadınlarda daha özel _____________________________________________________________________________________________________________________________

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Women hospitalized with atrial fibrillation: Gender differences, trends and outcome from a 20-year registry in a middle eastern country (1991–2010)

Cited by 21 publications

References 44 publications

Gender Differences of Thromboembolic Events in Atrial Fibrillation

Gender Differences of Thromboembolic Events in Atrial Fibrillation

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Women Sex Importance in Stroke Patients with Atrial Fibrillation

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