Women are taking the hit: Examining the unique consequences of cannabis use across the female lifespan

Gräfe, Erin L.; Reid, Hannah; Shkolnikov, Irene; Conway, Kevin P.; Kit, Ah; Acosta, Carlos Alberto Palacio; Christie, Brian R.

doi:10.1016/j.yfrne.2023.101076

Cited by 6 publications

(3 citation statements)

References 335 publications

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“…28 Studies suggest that the endocannabinoid system is involved in the pathophysiology of PTSD, particularly in women. [28][29][30] The endocannabinoid system is involved in communications between the amygdala and the prefrontal cortex, which regulates the control of fear extinction. Neuropharmacological studies report the effects of Δ9-THC on anxiety and memory to explain particularly high cannabis use in PTSD sufferers.…”

Section: Discussionmentioning

confidence: 99%

Greater vulnerability to cannabis dependence among heavy cannabis user French women

Guillem,

Baylé

2023

American J Addict

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Background and ObjectivesBetween 1990 and the mid‐2010s, France registered a sharp rise in the spread and consumption of cannabis. At the same time, there has been an increase in the concentration of Δ9‐tetrahydrocannabinol contained in cannabis. The aims of our study are to measure addictive and psychiatric comorbidities in cannabis users in France, and to compare characteristics between women and men.MethodsThree hundred and forty‐two heavy cannabis users seen in a cannabis clinic between 2004 and 2014 were assessed during a 2‐h clinical interview (DSM‐IV, MINI).Results83.2% of users are currently cannabis dependent, 10.6% alcohol dependent, and 2.1% cocaine/crack dependent. 37.8% have a current mood disorder, 47.6% have a current anxiety disorder, and 8.8% are psychotic. Women suffer significantly more often than men from major depressive episodes, dysthymia, agoraphobia, social phobia, generalized anxiety disorder and posttraumatic stress disorder (PTSD), both current and lifetime. Logistic regression shows that women have a significantly higher risk than men of suffering from PTSD over their lifetime (odds ratio [OR] = 5.48; p < 10−3). The vast majority of women suffering from PTSD report having been sexually assaulted in the course of their lives. In addition, women are at greater risk of cannabis dependence (OR = 3.87; p < .05) for lower cannabis consumption (grams smoked per week) (OR = 0.96; p < .05).Discussion and ConclusionsFrench women heavy cannabis users are particularly at risk of PTSD and are more likely than men to be dependent despite consuming fewer.Scientific SignificanceFurther studies are needed to clinically quantify cannabis consumption and distinguish its impact on women and men.

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Section: Discussionmentioning

confidence: 99%

Greater vulnerability to cannabis dependence among heavy cannabis user French women

Guillem,

Baylé

2023

American J Addict

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“…Consumption of recreational cannabis is illegal in Romania and even its medical use is controversial [1][2][3], despite the fact that new policies regarding recreational cannabis are being implemented around the world employing measures that aim for better information rather than punitive actions [2,4,5]. Moreover, prospective studies aimed at advancing the understanding of medical mechanisms and social implications are funded [6][7][8]. On the other hand, there are European countries, such as Romania, where simple possession is punishable with the possibility of imprisonment [2].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, there are European countries, such as Romania, where simple possession is punishable with the possibility of imprisonment [2]. Although some medical benefits of cannabinoids are widely accepted [8][9][10][11][12], the negative consequences of tetrahydrocannabinol use and addiction are also acknowledged and include: cognitive impairment [13][14][15][16], predisposition towards developing schizophrenia-related psychosis [15,[17][18][19], and mania [15,20]. Regardless of these recognized high risks, the drug's consumption has been on the rise worldwide since the mid-2000s, in spite of a previous decrease in the 1990s [5,15].…”

Section: Introductionmentioning

confidence: 99%

Medical Students’ Views on Cannabis Use in Recreational Contexts Are Related to Their Own Consumption Intention

Panfil,

Tamasan,

Marin-Bancila

et al. 2024

Societies

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Health professionals are regarded as important sources of information and guidance for healthy living. Knowing health determinants and risks, and invested with credibility in society, many struggle with their own human limits to apply these principles. A cross-sectional study was conducted among advanced medical students to assess their attitude towards recreational cannabis consumption, intention to use it, and their opinion of its legal status. Secondary objectives were to explore the relation of these primary outcomes to: (a) potentially addictive habits (such as smoking and drinking); (b) individuals’ disturbances in self-organization (DSOs), defined in the ICD-11 as pervasive chronic effects of traumatic experiences or stressful events. An anonymous online questionnaire active in November 2022 collected data from 171 medical students, of which almost 56% were in favor of recreational cannabis legalization. In a logistic regression analysis, each additional point of own consumption intention (on a scale from 1 to 5) was found to increase the odds of a positive opinion of legalization by three times, when controlling for gender, age, smoking, drinking, onset age of smoking, and DSO: OR = 2.918, 95%CI (1.893–4.497). In conclusion, health professionals’ personal beliefs and practices regarding substance use have a significant subjective component.

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Physical Activity Moderates the Relationship Between Frequency of Past 90-Day Cannabis Use on Psychological Distress Among a National Sample of College Students

Zeiger,

Conner

2024

Int J Ment Health Addiction

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Women are taking the hit: Examining the unique consequences of cannabis use across the female lifespan

Cited by 6 publications

References 335 publications

Greater vulnerability to cannabis dependence among heavy cannabis user French women

Greater vulnerability to cannabis dependence among heavy cannabis user French women

Medical Students’ Views on Cannabis Use in Recreational Contexts Are Related to Their Own Consumption Intention

Physical Activity Moderates the Relationship Between Frequency of Past 90-Day Cannabis Use on Psychological Distress Among a National Sample of College Students

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