Although humor is an integral part of human existence, its use in the doctorpatient relationship has not been studied extensively. Previous research has concluded that laughter between doctors and patients is asymmetrical, and that it serves to accentuate social distance. In a brief study of interactions between the author and two patients, abundant evidence of humor, with or without laughter, was found. This humor was varied and complex, and served to reinforce a sense of equality between physician and patient, to build a relationship between them, and to represent a sense of control and healing for the patient. Moreover, the humor did not detract from the patients’ perceptions of competent and professional medical care.