The BIOMED II ‘Improving Psychiatric Treatment in Residential Programmes for Emerging Dependency Groups’ project provided a relatively large sample (n = 863) of men (77%) and women (23%) in therapeutic community treatment in nine European countries. This paper’s aim is to search for gender differences in profiles of therapeutic community clients on the basis of the different areas of functioning of the EuropASI. A binary logistic regression model was used to avoid the confounding effects of country and age. Our findings confirm what is found in the American literature: compared to men, women have a much worse profile in various areas of functioning when entering treatment. In response, they may require a gender-adapted set of therapeutic interventions at the moment they enter treatment.