Women and acute kidney injury in myocardial infarction

Kanic, Vojko; Vollrath, Maja; Kompara, Gregor; Suran, David; Hojs, Radovan

doi:10.1007/s40620-018-0504-4

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…This condition is mostly related to the enhancement of coronary shear stress, which is mostly caused by high physical load or emotional stress in young people. Domestic studies have shown that with the increase of age, the number of coronary artery lesions in patients with acute coronary syndrome will also increase [18]. However, there is still no uniform conclusion on whether there is a difference in the number of coronary lesions between genders.…”

Section: Discussionmentioning

confidence: 99%

Intelligent Algorithm-Based Coronary Angiography Characteristics of Acute Non-ST-Segment Elevation Myocardial Infarction Patients with Different Genders

Cui

Wang

Peng

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. This study was aimed at comparing the characteristics of coronary angiography based on intelligent algorithm in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI) of different genders. Methods. Eighty patients were selected to segment the coronary angiogram using the convolutional neural network (CNN) algorithm, the input layer of the CNN was used to receive the image dataset, and three-dimensional data were input during semantic segmentation to achieve automatic segmentation of the target features. Segmentation results were quantitatively assessed by accuracy (Acc), sensitivity (Se), specificity (Sp), and Dice coefficient (Dice). The characteristics of coronary angiography were compared between the two groups. Results. The CNN algorithm had good segmentation effect, complete vessel extraction, and little noise, and Acc, Se, Sp, and Dice were 90.32%, 93.39%, 91.25%, and 89.75%, respectively. The proportion of diabetes mellitus was higher in female patients with NSTEMI (68.8%) than that in male patients (46.3%); the proportion of the left main coronary artery (LM) and left anterior descending artery (LAD) was lower in the female group (7.5%, 41.3%) than that in the male group (13.8%, 81.3%), and the difference between the two groups was statistically significant ( P < 0.05 ). Conclusion. The CNN algorithm achieves accurate extraction of vessels from coronary angiographic images, and women with diabetes and hyperlipidemia are more likely to have NSTEMI than men, especially the elderly.

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Section: Discussionmentioning

confidence: 99%

Intelligent Algorithm-Based Coronary Angiography Characteristics of Acute Non-ST-Segment Elevation Myocardial Infarction Patients with Different Genders

Cui

Wang

Peng

et al. 2022

Computational and Mathematical Methods in Medicine

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“…In fact, 55.6% of the high creatinine group have eGFR between 15 and 30 mL/min/1.73 m 2 . It has been found that a high mortality rate among COVID-19 patients and a higher probability of developing AKI were associated with lower GFR (51-85 mL/min/1.73 m 2 ) [20] [21] . Concerning electrolytes levels, our results demonstrated that serum sodium concentration was significantly lower in COVID-19 patients and even lower in the severe COVID-19 positive group compared to the non-severe group.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and hematological findings and risk factors associated with kidney impairment in patients with COVID-19

Yaghmour¹,

Shraim²,

Abbas³

2023

J Med Biochemistry

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Background : COVID-19 is a new pandemic that has infected millions of people worldwide and caused a high rate of morbidity and mortality. COVID-19 may have a harmful effect on body organs especially, the kidneys. Aims: The main aim of our research is to study the association between the severity of COVID-19 disease and biochemical parameters related to kidney function and to investigate certain risk factors of COVID-19-associated kidney disease. Methods: A total of 174 individuals, 121 COVID-19 positive and 53 COVID-19 negative were enrolled in this study. The relation between COVID-19 infection, severity, kidney function test, hematological indicators were examined. Results: The most prominent symptoms among COVID-19 were fever (95%) and fatigue (92%). Regarding biochemical parameters, median creatinine, MPV, and CRP were found to be significantly higher in COVID-19 patients, whereas median eGFR, Na⁺, WBC, MCH, MCHC, and eosinophil percentage were significantly lower in this group. Severely infected patients were observed to have higher urea, creatinine, neutrophils, and NLR. However, median sodium, eGFR, hemoglobin, hematocrit, RBC, lymphocytes, and platelets count were significantly lower in the severe group. Urine examination of severe group showed a significantly lower specific gravity, while urine pH, protein, and glucose were significantly higher. Conclusion : Our analysis indicates that COVID-19 infection affects kidney function mainly creatinine level, urea, eGFR, Na⁺ and urine protein. Additionally, comorbidities such as older age (≥65), hypertension, taking medications, and CRP (≥33.55mg/L) are considered risk factors which are more likely to contribute to kidney impairment in COVID-19 positive patients.

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“…Animal models have consistently shown a protective effect of female on the development of AKI after ischemia-reperfusion injury [6,25,26]. Contrary to these experimental observations, the direction of sexual dimorphism has been reported to be controversial in AKI in human [23,27]. Some studies demonstrated that female was associated with improved survival in critically ill patients with septic acute kidney injury [28].…”

Section: Relationship Of Findings To Other Relevant Studiesmentioning

confidence: 99%

Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis

Jiajia

Liu

et al. 2022

Gastroenterology Research and Practice

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Background. Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 48 h) serum estradiol level is associated with AKI in patients with MSAP and SAP. Patients and Methods. We retrospectively collected data from patients with preliminary diagnosis of MSAP and SAP from the Affiliated Hospital of Yangzhou University between January 2014 and June 2018. Serum sex hormones were extracted for further assessment within first 48 h following admission. Logistic regression analysis and the receiving operating characteristic (ROC) curve were applied to evaluate the association and correlation between serum sex hormones and AKI. Results. Data from a total of 122 patients with MSAP or SAP were enrolled in this study. There were no differences in the incidence of AKI between males and females. However, comparing with patients without AKI, those with AKI saw higher estradiol level ( p ≤ 0.01 ) and slight higher progesterone level ( p = 0.014 ) but similar testosterone level ( p = 0.668 ). Interestingly, during both the manual selection and the stepwise backward logistic regression analysis, serum estradiol level was independently associated with AKI in patients with MSAP and SAP (OR 4.699, CI 1.783-12.386, and p = 0.002 ). Additionally, area under the curve of ROC (AUCROC) showed that serum estradiol level was a proper predictor for AKI (area under the curve 0.875). Specifically, the serum estradiol level of 223.15 pg/mL demonstrated a 92.3% sensitive and a 79.3% specificity in predicting AKI of MSAP and SAP patients, respectively. Conclusions. High baseline serum estradiol level appears to be an independent risk factor for AKI in patients with MSAP and SAP. It also tends to be an appropriate indicator for AKI.

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Women and acute kidney injury in myocardial infarction

Cited by 12 publications

References 29 publications

Intelligent Algorithm-Based Coronary Angiography Characteristics of Acute Non-ST-Segment Elevation Myocardial Infarction Patients with Different Genders

Intelligent Algorithm-Based Coronary Angiography Characteristics of Acute Non-ST-Segment Elevation Myocardial Infarction Patients with Different Genders

Biochemical and hematological findings and risk factors associated with kidney impairment in patients with COVID-19

Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis

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