In Self-Culture and the Perfection of Character (1847), the American phrenologist, Orson Fowler, offered phrenology as a remedy for those who 'are daily and earnestly inquiring-"How can I REMEDY my defects? By what MEANS can I increase my deficient organs, and diminish or regulate those that are too large? … How can I make my children better?" ' 1 Orson and his brother, Lorenzo, founded a phrenological and publishing empire in mid-nineteenth-century America that revitalised and popularised this heterodox medical practice. Phrenology had enjoyed widespread, if controversial, application within Western medicine in the century's first decades, but by the 1840s, it had been marginalised and largely branded as quackery, as laboratory-based biomedicine increasingly monopolised the medical marketplace. Phrenology began in the late eighteenth century under the Viennese physician Franz Joseph Gall, who argued that the brain is an aggregate of mental 'organs' , each with localised and specific functions such as fidelity, ambition, or poetic talent. The larger the organ, the greater the corresponding faculty, which could be measured by the size and shape of the skull. Thus, phrenology could explain the relative strengths and weaknesses of a person's mind and character. Although phrenology's claims were not substantiated by experimental scientific method, historians of science have traced the real and lasting impact of Gall's thinking, from the diffusion of scientific naturalism that prepared the public for Darwinian evolution, to its influence upon fields as diverse as