Wollastonite/TCP composites for bone regeneration: systematic review and meta-analysis

Abstract

Composite biomaterials have gained notoriety in recent decades due to the ability to combine desirable properties of each material. Thus, associating bioactivity of wollastonite (W) with biodegradability of tricalcium phosphate (TCP) becomes promising for bone repair. Therefore, this study investigated, through systematic review and meta-analysis, in vivo studies that evaluated histomorphometrically the bone repair after implantation of W/TCP composites. The searches were performed in the PubMed/MEDLINE, LILACS/BIREME/Virtual Health Library (VHL), and Scientific Electronic Library Online (SciELO) databases. A total of 312 studies were identified in the databases, of which 6 were included. In data comparison, it was considered the percentage of neoformed bone (NB). Composites with a higher percentage of W and/or in the scaffold format presented higher NB. These results suggested that the association of these two materials, as well as the porous scaffold format, was determinant on NB, which makes these new composites potential for clinical use.

Wollastonite and tricalcium phosphate composites for bone regeneration

“…During the new biomaterials synthesis, CS and CaP have been choice materials (Nair et al, 2009;Sole;Grima, 2018) given this combination has shown promising results as bone substitutes used individually (Lin et al, 2009;Wang et al, 2012;Santos et al, 2020).…”

“…Although p-W is stable polymorphic silica at temperatures above 1030ºC, it has a crystalline structure capable of directly connecting with bone tissue De Aza, 1994). For biomedical purposes, W has been synthesized, processed, and used in different geometric presentation formats and shapes, such as metal alloy coatings, microspheres, granules, or sintered or non-sintered porous 3D scaffolds (Sola;Grima, 2018;Yu et al, 2018;Ge et al, 2019;Srinath et al, 2019;Kamboj et al, 2020;Meireles;Santos et al, 2021;Monção et al, 2022). This is related to the fact that when compared to the other bone replacement materials used clinically, such as CaP, W has higher bioactivity due to the release effect of Ca 2+ and silicate (SiO3 2− ), substantial during the osteogenesis mechanism (Ni;Hesaraki et al, 2009;Yu et al, 2018;Ge et al., 2019).…”

O uso de biomateriais em odontologia: novas perspectivas e atualizações

“…Os biomateriais se tornaram essenciais para restaurar e regenerar no menor tempo possível estruturas e funções perdidas quando a reparação tecidual não pode ser concluída em razão da falta de suprimento sanguíneo. A perda extensiva de tecidos podem ser causadas por infeções, neoplasias, doenças congênitas e outros distúrbios do tecido ósseo (dos Santos et al, 2020).…”