volume 5, issue 10, Pe13398 2010
DOI: 10.1371/journal.pone.0013398
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Abstract: BackgroundDengue is currently the most important arthropod-borne viral disease of humans. Recent work has shown dengue virus displays limited replication in its primary vector, the mosquito Aedes aegypti, when the insect harbors the endosymbiotic bacterium Wolbachia pipientis. Wolbachia-mediated inhibition of virus replication may lead to novel methods of arboviral control, yet the functional and cellular mechanisms that underpin it are unknown.Methodology/Principal FindingsUsing paired Wolbachia-infected and …

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