2015
DOI: 10.3390/v7082836
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Wolbachia Do Not Induce Reactive Oxygen Species-Dependent Immune Pathway Activation in Aedes albopictus

Abstract: Aedes albopictus is a major vector of dengue (DENV) and chikungunya (CHIKV) viruses, causing millions of infections annually. It naturally carries, at high frequency, the intracellular inherited bacterial endosymbiont Wolbachia strains wAlbA and wAlbB; transinfection with the higher-density Wolbachia strain wMel from Drosophila melanogaster led to transmission blocking of both arboviruses. The hypothesis that reactive oxygen species (ROS)-induced immune activation plays a role in arbovirus inhibition in this s… Show more

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Cited by 31 publications
(40 citation statements)
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“…However in our experiments, and in w Mel-infected Ae . albopictus , Wolbachia did not affect duox-2 levels, potentially because the gene lacks peroxidase activity, and therefore cannot directly stimulate ROS [43]. As we observed ROS induction without an effect of Wolbachia on duox-2 , this implies that ROS induction occurs via a different process, potentially via the duox-1 gene.…”
Section: Discussionmentioning
confidence: 64%
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“…However in our experiments, and in w Mel-infected Ae . albopictus , Wolbachia did not affect duox-2 levels, potentially because the gene lacks peroxidase activity, and therefore cannot directly stimulate ROS [43]. As we observed ROS induction without an effect of Wolbachia on duox-2 , this implies that ROS induction occurs via a different process, potentially via the duox-1 gene.…”
Section: Discussionmentioning
confidence: 64%
“…However, it is not universal amongst all host-strain associations where pathogen interference occurs, as is the case for w Mel-infected Ae . albopictus , where there is interference against DENV and Chikungunya virus infection [43, 76, 77]. The fact that ROS induction occurs for w Mel-infected Ae .…”
Section: Discussionmentioning
confidence: 99%
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“…It is therefore unlikely that induction of ROS upon Wolbachia infection correlates with Toll pathway activation in Drosophila. Although the mechanistic involvement of ROS in the insect antiviral response remains to be elucidated, and a recent study has reported that Wolbachia do not induce ROS in Aedes albopictus (Molloy & Sinkins, 2015), ROSrelated responses may constitute a promising area for future research in understanding Wolbachia-mediated antiviral effects (Zug & Hammerstein, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to A. albopictus, in which no impact of Wolbachia on immunity has been observed (Bourtzis et al, 2000;Molloy and Sinkins, 2015), wAlbB induces the production of reactive oxygen species and activates the Toll pathway in WB1 strain A. aegypti . In addition, wAlbB has been shown to grow to significantly higher densities in WB1 than in A. albopictus and invade different tissues such as the fat body, midgut, salivary glands, and ovaries .…”
Section: Introductionmentioning
confidence: 93%