“…CDK5 has been proposed to contribute to a variety of procancer functions, including cell migration, proliferation, and survival (Goodyear and Sharma, 2007;Demelash et al, 2012); maintenance of RasRal signaling (Feldmann et al, 2010); and promotion of the TGFb-induced epithelial to mesenchymal transition (Liang et al, 2013). Likewise, accumulating evidence indicates a role for CDK8 in some human cancers (Firestein et al, 2008;Gu et al, 2013;He et al, 2013;Li et al, 2014a,b,c;Xu et al, 2015). Fig.…”